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Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway, thereby inducing favorable osteo-immunomodulatory effects. Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions, and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients.Severe ischemic stroke damages neuronal tissue, forming irregular-shaped stroke cavities devoid of supporting structure. Implanting biomaterials to provide structural and functional support is thought to favor ingrowth of regenerated neuronal networks. Injectable hydrogels capable of in situ gelation are often utilized for stroke repair, but challenged by incomplete gelation and imprecise control over end-macrostructure. Injectable shape-memory scaffolds might overcome these limitations, but are not explored for stroke repair. Here, we report an injectable, photoluminescent, carbon-nanotubes-doped sericin scaffold (CNTs-SS) with programmable shape-memory property. By adjusting CNTs' concentrations, CNTs-SS' recovery dynamics can be mathematically calculated at the scale of seconds, and its shapes can be pre-designed to precisely match any irregular-shaped cavities. Using a preclinical stroke model, we show that CNTs-SS with the customized shape is successfully injected into the cavity and recovers its pre-designed shape to well fit the cavity. Notably, CNTs-SS' near-infrared photoluminescence enables non-invasive, real-time tracking after in vivo implantation. Moreover, as a cell carrier, CNTs-SS not only deliver bone marrow mesenchymal stem cells (BMSCs) into brain tissues, but also functionally promote their neuronal differentiation. Together, we for the first time demonstrate the feasibility of applying injectable shape-memory scaffolds for stroke repair, paving the way for personalized stroke repair.<br />It is clinically recognized that collateral vessels can form after retinal vein occlusion (RVO) in some cases and these vessels can lead to spontaneous recovery of the pathological condition. In recent years, optical coherence tomography angiography (OCTA) has become a decisive clinical instrument. Unlike previous angiography tests, OCTA enables the non-invasive visualization of fundus vasculature without the need for administration of a contrast agent. However, it remains to be determined if OCTA depicts the 'true' histological status as several studies have reported artifacts in OCTA imaging.<br />We generated a laser-induced mouse RVO model, and evaluated the subsequent formation of collateral vessels in order to understand the mechanisms by which collateral vessels form using OCTA imaging, as well as molecular and histological assessments.<br />We succeeded in visualizing the time course of collateral vessel formation in a mouse RVO model and confirmed the similarity in formation of collateral vessels only wiween S1PR1 and shear stress as one of the factors in collateral vessel formation in RVO.Arbuscular mycorhizal fungi (AMF) associated to plants may represent a promising phyto-remediation avenue due to the widely documented role of these fungi in alleviation of numerous abiotic (e.g. heavy metals) stresses. In the present work, it was the objective to study the dynamics of inorganic phosphorus (Pi) and chromium(VI) (Cr(VI)) and total Cr uptake by the plant-AMF associates Zea mays + R. irregularis MUCL 41833, under increasing (i.e. 0, 0.1, 1 and 10 mg L-1) concentrations of Cr(VI). The plant-AMF associates were grown in a circulatory semi-hydroponic cultivation system under greenhouse conditions. We demonstrated that Cr(VI) had an hormesis effect on root colonization of maize. Indeed, at 0.1 and 1 mg L-1 Cr(VI), root colonization was increased by approximately 55% as compared to the control (i.e. in absence of Cr(VI) in the solution), while no difference was noticed at 10 mg L-1 Cr(VI) (P ≤ 0.05). However, this did not result in an increased uptake of Pi by the AMF-colonized plants in presence of 0.1 mg L-1 Cr(VI) as compared to the AMF control in absence of Cr(VI) (P ≤ 0.05). Conversely, the presence of 1 mg L-1 Cr(VI) stimulated the Pi uptake by non-mycorrhizal plants, which absorbed 17% more Pi than their mycorrhizal counterparts (P ≤ 0.05). In addition, the non-mycorrhizal plants absorbed, in average, 8% more Cr(VI) than the mycorrhizal plants. Overall, our results prompt the hypothesis that in presence of AMF, the regulation of uptake of Cr(VI) and Pi by plant roots is done mostly by the fungus rather than the root cells. [https://www.selleckchem.com/products/tepp-46.html read more] This regulated uptake of roots associated to AMF would indicate that the symbiosis could benefit the plants by providing a stable Pi uptake in a Cr(VI) polluted environment.<br />Polycystic Ovarian Syndrome (PCOS) is a multifactorial endocrine-metabolic disorder that highly contributes to the prevalence of infertility globally. The increased consumption of refined carbohydrate, particularly fructose has been associated with pandemic metabolic disorders, including in women of reproductive age. However, the effects of high fructose consumption (FRD) on endocrine and metabolic disorders associated with PCOS are not clear. Therefore, this study investigated the effects of FRD on endocrine/metabolic changes in letrozole-induced PCOS in Wistar rats.<br />Twenty-eight adult female Wistar rats were randomly allotted into 4 groups and treated with vehicle, letrozole (LET; 0.5 mg/kg), FRD (D-fructose chow pellet mixture) and LET + FRD. The treatment lasted for 21days.<br />Data showed a significant increase in ovarian weight, liver weight, luteinising hormone (LH), testosterone and decrease in follicle stimulating hormone as well as moderate histopathological changes in the fallopian tube, uterus and liver of animals with PCOS. FRD-treated group showed a significant increase in ovarian weight and liver weight but no significant alteration in hormonal profile or histopathological changes in uterus and fallopian tube. However, FRD significantly altered hormonal profile with consequent histopathological changes in fallopian tube and uterus but FRD did not alter ovarian/liver weight or blood glucose in animals with PCOS when compared with animals without PCOS.<br />The present results demonstrate that FRD synergistically aggravates endocrine but not metabolic changes in PCOS, suggesting that FRD might deteriorate endocrine-related phenotypes in PCOS.<br />The present results demonstrate that FRD synergistically aggravates endocrine but not metabolic changes in PCOS, suggesting that FRD might deteriorate endocrine-related phenotypes in PCOS.