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58-0.99, p=0.046), and the "GA" genotype of rs2274223 was associated with increased EC risk under co-dominant model (OR=1.36, 95% CI 1.04-1.77, p=0.023). Using GTEx database, rs2274223 was found to be significant associated with increased PLCE1 expression (p=4.1 × 10<br />) in esophagus muscularis. The UALCAN database demonstrated that the GHR gene was under-expressed in esophageal cancer tissues (p=0.017).<br />The gene GHR and PLCE1 polymorphisms are associated with EC in the general population and the results need to be verified in future.<br />The gene GHR and PLCE1 polymorphisms are associated with EC in the general population and the results need to be verified in future.<br />As a result of the pandemic of COVID-19, the public have been experiencing psychological distress. However, the prevalence of psychological distress during the COVID-19 pandemic remains unknown. Our objective was to evaluate the prevalence of psychological distress during COVID-19 outbreak and their risk factors, especially their internal paths and causality.<br />A nationwide cross-sectional survey of the prevalence of mental disorders was conducted. We used Hospital Anxiety and Depression Scale (HADS) to estimate the prevalence of anxiety and depression. The internal paths and the causality of the psychological health were analyzed using a structural equation modeling (SEM) approach.<br />A total of 24,789 respondents completed the survey. We found that the overall prevalence of anxiety, depression, combination of anxiety, and depression were 51.6% (95% CI 51.0-52.2), 47.5% (95% CI 46.9-48.1), and 24.5% (95% CI 24.0-25.0), respectively. The risk of psychological disorders in men was higher than that in women. The status of psychological health was different across different age groups, education levels, occupations, and income levels. The SEM analysis revealed that inadequate material supplies, low income, low education, lack of knowledge or confidence of the epidemic, and lack of exercise are major risk factors for psychological distress.<br />The evidence from this survey poses serious challenges related to the high prevalence of psychological distress, but also offers strategies to deal with the mental health problems caused by the COVID-19 pandemic.<br />The evidence from this survey poses serious challenges related to the high prevalence of psychological distress, but also offers strategies to deal with the mental health problems caused by the COVID-19 pandemic.<br />Bladder cancer (BCa) is the most common urinary malignancy. The standard surgical treatment for patients with muscle-invasive BCa is cystectomy plus urinary diversion. Ileal conduit (IC) or orthotopic neobladder (ON), which have different indications, are the most commonly performed urinary diversions.<br />We sampled 5480 BCa patients from the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2015. Kaplan-Meier method with the log-rank test was used to assess cancer-specific survival (CSS) and overall survival (OS). Univariate and multivariate Cox's proportional hazard model was conducted to evaluate the hazard ratio of cancer-specific mortality and all-cause mortality before and after propensity score matching (PSM).<br />We identified 5480 patients who received radical cystectomy (RC) plus IC (n=5071) or ON (n=409) with a median follow-up period of 33months (interquartile range, 13-78months). Patients in the ON group tended to be male and younger, with a higher percentage of married individuals, early pathological T stage, lymphadenectomy, and non-radiotherapy (all P&lt;.05). After 11 PSM, 409 matched pairs were selected. [https://www.selleckchem.com/products/Y-27632.html Y-27632 concentration] Univariate and multivariate analysis showed that the ON group had better CSS and OS probabilities than the IC group in the overall cohort [hazard ratio (HR) 0.692, 95% confidence intervals (CI) 0.576-0.831, P&lt;.001; HR 0.677, 95% CI 0.579-0.793, P&lt;.001 respectively]. However, subgroup analysis revealed that only patients with pathological T2 stage benefited from ON diversion after PSM in the context of CSS (P=.016) and OS (P&lt;.001).<br />Young, married, and male patients with early pathological T stage, especially T2 stage, were more suitable to receive RC plus ON surgery, which could improve their probability of survival.<br />Young, married, and male patients with early pathological T stage, especially T2 stage, were more suitable to receive RC plus ON surgery, which could improve their probability of survival.<br />Few investigations have been conducted to identify genetic determinants of common, polygenetic forms of heart failure (HF), and only a limited number of these genetic associations have been validated by multiple groups.<br />We performed a case-control study to further investigate the potential impact of 14 previously reported candidate genes on the risk of HF and specific HF sub-types. We also performed an exploratory genome-wide study. We included 799 patients with HF and 1529 controls. After adjusting for age, sex, and genetic ancestry, we found that the C allele of rs2234962 in BAG3 was associated with a decreased risk of idiopathic dilated cardiomyopathy (odds ratio 0.42, 95% confidence interval 0.25-0.68, P=0.0005), consistent with a previous report. No association for the other primary variants or exploratory genome-wide study was found.<br />Our findings provide independent replication for the association between a common coding variant (rs2234962) in BAG3 and the risk of idiopathic dilated cardiomyopathy.<br />Our findings provide independent replication for the association between a common coding variant (rs2234962) in BAG3 and the risk of idiopathic dilated cardiomyopathy.<br />Maternal feeding style has been associated with childhood obesity and has been the target of numerous interventions, but few studies included fathers.<br />We assessed correlations and associations between maternal and paternal feeding style.<br />We examined 202 mothers, fathers, and infants in Nurture, a racially diverse US cohort (2013-2017). Mothers and fathers completed the Infant Feeding Style Questionnaire when infants were 6 and 12 months. We examined unadjusted correlations using Spearman's Rho and adjusted associations using linear regressions.<br />All feeding styles were significantly correlated. After adjustment, maternal feeding style was associated with paternal feeding style at 6 and 12 months for responsive (ß 0.31; CI 0.18, 0.45; P ≤ 0.0001 and ß 0.67; CI 0.50, 0.84; P ≤ 0.0001), restrictive (ß 0.24; CI 0.09, 0.38; P = 0.001 and ß 0.44; CI 0.29, 0.59; P ≤ 0.0001), pressuring (ß 0.46; CI 0.34, 0.58; P ≤ 0.0001 and ß 0.51; CI 0.38, 065; P ≤ 0.0001), indulgent (ß 0.36; CI 0.20, 0.52; P ≤ 0.0001 and ß 0.