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Sickle Cell Disease (SCD) is a chronic hemolytic disorder associated with frequent pain episodes, end organ damage and a shortened lifespan. Currently there exist no disease specific targeted therapies for the treatment of acute vaso-occlusive crisis (VOC) and management with analgesics and hydration is purely supportive. Improvement in understanding of disease pathophysiology has resulted in a great interest in disease modifying novel therapies and many are being evaluated in clinical trials. Here we report the results from the pre-specified mid-point analysis of the Phase 2 study of Intravenous Gamma Globulin (IVIG) for the treatment of acute VOC in patients with SCD and lessons learned.<br />Virtual reality (VR) is being used more and more often as a therapeutic tool in psychology or psychiatry. In recent years, VR interventions appear more extensively also in disorders such as depression, anxiety and phobia. However, there has yet to be a comprehensive synthesis and critical review of the literature to identify future directions to advance the field in this area.<br />To broadly characterize the literature to date on the application of VR in psychiatric disorders by conducting a systematic review of reviews, describe the limitations of existing research, suggest avenues for future research to address gaps in the current literature and provide practical recommendations for incorporating VR into various treatments for psychiatric disorders.<br />PubMed and Web of Science databases were searched for reviews on VR use in psychiatric disorders (e.g. various pain perceptions, post-traumatic stress disorder, phobias, attention deficit hyperactivity disorder, psychosis, depression). The methodological qualino review has concluded that VR does not work.<br />The consumption of nuts and edible seeds is associated with the improvement of the metabolic profile and reduction of cardiovascular diseases. However, the effects of its subproducts, such as oil, are still poorly studied. This study aimed to evaluate the effect of the baru almond oil supplementation on inflammation, oxidative stress, body composition, lipid profile, and plasma fatty acids of hemodialysis patients.<br />In a randomized, double-blind, 12-week placebo-controlled clinical study, hemodialysis patients were supplemented with 5 g of baru oil (BG, n = 17) or 5 g of mineral oil (placebo, BP, n = 12). Body composition, renal function, ultra-sensitive C-reactive protein (us-CRP), oxidative stress, plasma fatty acids, and lipid profile were analysed before and after the intervention.<br />Patients were aged 50.5 ± 2.2 years and the average time of dialyses was 52,1 ± 42,6 months. The BG decreased us-CRP concentration compared to PG (-1.2 ± 0.2 vs. + 0.8 ± 0.2 mg / L,d = 0.88; p =  0.01). Baru almond oil supplementation was not effective in improving body composition, lipid profile, and oxidative stress.<br />Baru almond oil supplementation decreased us-CRP concentration in patients with chronic kidney disease under hemodialysis treatment.<br />Baru almond oil supplementation decreased us-CRP concentration in patients with chronic kidney disease under hemodialysis treatment.<br />Several randomized controlled clinical trials (RCTs) have investigated the effect of pomegranate (Punica granatum) supplementation in patients with type 2 diabetes mellitus (T2DM), with conflicting results. Therefore, the present study assessed the effect of pomegranate on metabolic status and oxidative stress in patients with T2DM.<br />A comprehensive search was conducted in Pubmed, EMBASE, ISI web of science, Cochrane library and Scopus databases until April 2020, to identify RCTs investigating the effect of pomegranate supplementation on glycemic markers (fasting blood glucose (FBG), homeostasis model assessment-estimated insulin resistance index (HOMA-IR), glycosylated hemoglobin percentage (HbA1c) and insulin levels), anthropometric indices (body mass index (BMI) and body weight (BW)), blood lipids (triglycerides (TG), total cholesterol (TC), high lipoprotein cholesterol (HDL-C) and low lipoprotein cholesterol (LDL-C)), inflammatory markers (high sensitive c-reactive protein (Hs-CRP)) and markers of oxidative stress (total antioxidant capacity (TAC)) in adults with T2DM. Mean difference was pooled using a random-effects model.<br />Seven trials, comprising 350 participants, were included in the present systematic review and meta-analysis. The results of the meta-analysis revealed that pomegranate supplementation did not have any significant effects on metabolic status and oxidative stress biomarkers of subjects with T2DM. There were no evidence of publication bias regarding to selected outcomes.<br />There were no significant favorable effects of pomegranate supplementation on metabolic parameters in patients with T2DM. Future well-designed, large scale RCTs, with longer duration are needed in this field.<br />There were no significant favorable effects of pomegranate supplementation on metabolic parameters in patients with T2DM. Future well-designed, large scale RCTs, with longer duration are needed in this field.<br />The aim of this article is to analyze the development of integrative oncology from a bibliometric point of view. The publication and citation patterns of publications are analyzed and their contents mapped.<br />This study is based on bibliometric methods. The data sets consist of 7 025 respectively 4 990 publications over the time period 1966-2016, shown in PubMed and Web of Science.<br />The expansion of the numbers of these publications took place in the late 1990s/early 2000s. Research is dominated by authors located in the USA, China and Germany who are working at well-established research universities and university hospitals. The clinical share of publications is relatively small, and few studies are classified according to clinical phase. [https://www.selleckchem.com/products/bromelain.html selleck products] Content analysis revealed that much of the clinical research is based on surveys, and that content reflects the intersection of complementary therapies and cancer research. The latter aspect is less obvious in pre-clinical research. The most frequent journals in the material show a focus on complementary and alternative therapies or on integrative oncology, although journals focused on oncology or general/internal medicine were well-represented in the material as a whole.