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Since biosimilars have a lower cost than reference drugs, their use represents a possibility of containing health care costs and of satifying the growing demand in terms of efficacy and personalization of pharmacological therapies. Considering the particular severity of the diseases treated, including colorectal and ovarian cancers, biosimilar drugs must be used with full awareness, in terms of efficacy and safety, since their approval is based on a rigorous analytical process, as well as preclinical and clinical evaluation.In recent years, pathological diagnostics have increasingly become an integrated component in a multidisciplinary anatomo-clinical context, of which it is essential to know all the implications in order to manage diagnostic-predictive analyses with maximum effectiveness and efficiency. The encouraging results related to the recent anticipation of the use of TKIs, including osimertinib, from the metastatic setting of non-small cell lung cancer (NSCLC) to the setting of stage IB-IIIA disease, underline the importance of adapting pathologic pathways in order to guarantee the execution of diagnostic investigations, in particular molecular tests, in an increasing proportion of NSCLC patients. In this document, the authors intend to provide simple recommendations regarding the main requirements of the pathological pathway for the appropriate management of this disease. Firstly, the critical issues of the pre-analytical phases concerning both the cytology/biopsy samples and the surgically-resected tissues were highlighted and some solutions were then provided in order to guarantee accuracy, adequacy and sustainability in the innovative approach that will be introduced in clinical practice for NSCLC patients.The gradual availability of genomic profiling tests and the "agnostic approvals" from FDA and EMA have opened the oncology mutational model phase, which complements and integrates the traditional hystological approach. The non-small-cell lung cancer (NSCLC) is characterized by many molecular alterations and represents the need of a change from the traditional diagnostic, therapeutic and organisational paradigms to the "mutational" ones. From the Italian National Healthcare System point of view, access and reimbursement of drugs based on the hystological model were managed thorugh the Italian Medicines Agency's (AIFA) monitoring registries and the managed entry agreements risk-sharing, cost-sharing and payment by results. The Italian reference oncological centres, which contributed to this report with their experiences, have shown the heterogenous approach to the molecular diagnostics (included next generation system tests). Facing the high complexity of the mutational model, outcomes handling and genomic profiling tests access inevitably result different among centres. The activation of multidisciplinary groups for the government of clinical processes, appropriateness and economic sustainability are essential. [https://www.selleckchem.com/products/ethyl-3-aminobenzoate-methanesulfonate.html Ethyl 3-Aminobenzoate] The Molecular Tumor Board (MTB) allows the management of such complexity, the interpretation of genomic profiling outcomes and the choice of drugs that are alrealdy authorized by AIFA, off-label or still under investigation. Moreover, in order to guarantee the uniformity, the data traceability and the transparency of assessment reports, a network of MTB must be validated by AIFA through specific criteria. To date, the oncological centres presented by this report are undergoing the experimental phase of the national genomic operating system implementation and represent the starting point of the deep organisational changement to the mutational approach and of its real and appropriate integration into the daily clinical practice.Although there is considerable evidence that precision anticancer drugs may be more effective than "one size fits all" approach, doubts persist about their cost, availability, and overall benefit for patients. With increasing frequency, patients with metastatic malignancies are undergoing next-generation sequencing (NGS) procedures to determine if there is a viable mutation that could guide their first or next line of treatment. However, this could be prohibitive for many disadvantaged patients. Furthermore, efficacy studies are often structured around surrogate endpoints of dubious long-term predictive validity. Moreover, it is necessary to add that it is often a therapy with significant toxicities, especially in over-treated patients. There is no doubt that precision medicine represents the near future of medical oncology, however, questions need to be asked, out of the spotlight and much closer to our patients.The Centers for Disease Control and Prevention announced fully vaccinated people need no longer wear a mask or physically distance to prevent the spread of covid-19 (with the exception of places where such measures remain required by law). The unexpected announcement does present an opportunity to interrogate why we have done what we have done during the pandemic, and what we want, or perhaps should want, to guide our decision-making during these times. The key question is "what is health for?". Also, covid-19 confronted us with a question which engages directly with this issue of tradeoffs and balance what are we willing to give up in order to get to health? How we respond depends on how we define health. Health could be better defined as an activity capable of balancing risk mitigation with the reasonable risk inherent in the pursuit of a full life, with health seen as a means to live a fulfilling life. If we truly believe that health matters, our pursuit of it should reflect the understanding that we do not live to be healthy we aspire to be healthy so we can live.The Caribbean region faces a growing burden due to cancer. Urgent action needs to be taken to monitor this disease and inform measures required for prevention and control. Cancer surveillance, supported by the implementation of population-based cancer registries (PBCRs), is an important component of cancer prevention and control strategies. Yet, the ability of some Caribbean countries to implement infrastructure needed for sustainable, high-quality PBCRs remains a challenge given limitations in resources and competing health priorities. While some Caribbean cancer registries have been successful in contributing high-quality cancer data in support of national cancer control and prevention efforts, this represents coverage of only a small percentage of the Caribbean population, and these data have limited generalizability to other countries in the region. The International Agency for Research on Cancer (IARC) Caribbean Cancer Registry Hub (http// caribbeancrh.carpha.org) is performing an important role in providing technical support, capacity building, advocacy, and research needed for strengthening cancer registration in the region.