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There was no difference in terms of total vitamin D between groups during the winter season.<br />While total, free, bioavailable vitamin D in obese group was similar to the control group in autumn, free and bioavailable vitamin D in the winter was lower than the control group. Also PTH was higher in obese group than the control group in both autumn and winter. Therefore, many more studies are needed to evaluate the variability of free, bioavailable vitamin D according to the seasons and its effects.<br />While total, free, bioavailable vitamin D in obese group was similar to the control group in autumn, free and bioavailable vitamin D in the winter was lower than the control group. Also PTH was higher in obese group than the control group in both autumn and winter. Therefore, many more studies are needed to evaluate the variability of free, bioavailable vitamin D according to the seasons and its effects.AAbstract Background/aim Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings.<br />Age and gender-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the Disease Activity Score 28-C reactive protein (DAS 28-CRP). Rheumatoid factor (RF) positivity, anti-citrullinated protein antibodies (ACPA) positivity, erythrocyte sedimentation rate (ESR), CRP, tender and swollen joint counts, and medical treatment regimens of the patients (glucocorticoids, conventional or biologic disease-modifying antirheumatic drugs) wers causes tissue damage in response to excessive mechanical loading, which in turn promotes TMD. However, disease activity has not a prominent impact on the salivary oxidative stress status of RA patients.<br />The objective of the study was to evaluate the response, relapse, reproductive results and demographic features of the patients with endometrioid adenocancer (EAC) and endometrial intraepithelial neoplasia (EIN) who were treated with conservative treatment. This is the largest study when we consider the single center studies in this field.<br />In the current retrospective study, 38 patients (6 EAC, 31 EIN, 1 synchron tumors of ovary and endometrium) were recruited. They were treated with progesterone products for their fertility desire and comorbidity. Reproductive results, response rates, recurerence rates and survival analyses had calculated.<br />Mean duration of the medical treatment was 10 months (range 2-60). Among the 32 patients with EIN, 28 (87.5%) had a response, 8 (25%) had a relapse and 4 (12.5%) had a persistance. Among the 32 patients who expecting fertility, seven patients got pregnant (21.8%) with a total of five live births. The median follow-up was 40.5 months (range 3-180), and recurrence-free interval was 28.7 (range 2-180).<br />Fertility-sparing treatment of EAC and EIN is feasible approach and a chance should be given to spontaneous pregnancies nearby artificial reproductive techniques.<br />Fertility-sparing treatment of EAC and EIN is feasible approach and a chance should be given to spontaneous pregnancies nearby artificial reproductive techniques.<br />Pediatric kidney transplantation (PKT) anesthesia brings some different challenges than adult kidney transplantation (KT) anesthesia and there are still no studies analyzing the role of experience on PKT outcomes. In this study, we aimed to evaluate the anesthesia learning curve in pediatric kidney transplants performed in our institution and the effect of increasing experience on renal transplantation-related data.<br />Patients age ≤ 18 years who underwent KT were included in the study, while patients age &gt;18 years were excluded. Patients were divided into 3 groups according to the date of transplant, as the first 10 patients in Group 1, the second 10 patients in Group 2, and the final 11 in Group 3. Groups were compared according to recorded data.<br />Thirty-one patients were included in the study. Age, sex, and body mass index were matched between the 3 groups. The mean durations of dialysis were 75.0 ± 63.0, 22.4 ± 27.9, and 5.7 ± 4.5 months for Group 1, Group 2, and Group 3, respectively (p = 0.009). Bltive dialysis duration and operative RBC transfusion, 20 patients may be enough for anesthesia competency. Transplantation anesthesia experience before PKT, anesthesia technique, and patient characteristics may differ between institutions. Therefore, further prospective studies with established learning curve goals, larger patient volumes, and more variables are needed to validate our results.<br />Use of topical anesthesia before flexible bronchoscopy for the evaluation of the upper airways prevents cough and stridor during and after the procedure while reducing the need for sedation. In practice, lidocaine is the medication of choice before bronchoscopy. There various types of nebulizers used for inhalation treatments. In this study, we compared the respiratory tract symptoms after flexible bronchoscopy between children who received pre-procedure topical lidocaine with mesh or jet nebulizers.<br />We enrolled 4-18 years old subjects that underwent flexible bronchoscopy due to treatment-resistant asthma in this retrospective case-control study. Twenty subjects received topical lidocaine with jet nebulizers while 20 received it with mesh nebulizers. [https://www.selleckchem.com/products/vtx-27.html VTX-27 in vivo] Age, sex, duration of bronchoscopy, duration of anesthesia, time to awaken, and time to recovery were recorded as well as cough and laryngospasm scores after flexible bronchoscopy.<br />Severe cough after flexible bronchoscopy was not encountered in the mesh neb way of nebulization before flexible bronchoscopy as an alternative to jet nebulizers.<br />Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease that causes recurrent attacks of fever, polyserositis, arthritis or skin eruptions, resulting in pain in the abdomen, muscles, joints and chest. All of these might lead to a reduction in exercise capacity, muscle strength, physical activity level (PAL) and quality of life (QoL). Therefore, assesment of these parameters are important. The aim of this study was to assess exercise capacity, muscle strength, PAL and QoL in patients FMF as compared to controls.<br />40 subjects with FMF and 36 healthy control subjects participated in the study. The 6-Minute Walk Test (6MWT) was used to assess exercise capacity. Muscle strength measurements for shoulder flexors, extensors and abductors, hip flexors, extensors and abductors, knee flexors and extensors, and ankle dorsiflexors were evaluated by hand-held dynamometer. PAL was assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF). QoL was investigated by Nottingham H important to evaluate and improve these parameters in patients with FMF.<br />Biochemical markers are needed to show lung involvement in COVID-19 disease. Galectin-3 is known to play a key role in the inflammation and fibrosis process. We aimed to evaluate the predictive role of Galectin-3 levels for pneumonia in patients with COVID-19.<br />Total of 176 patients with COVID-19, confirmed with reverse transcriptase polymerase chain reaction, admitted to the Erzurum Regional Training and Research Hospital was analyzed. The study was designed as a cross sectional. The baseline data of laboratory examinations, including galectin-3 were collected at the time of diagnosis. CT images evaluated by a single radiologist according to the recommendation of the Radiological Society of North America Expert Consensus Document for pulmonary involvement. The severity of COVID-19 pneumonia was assessed using the total severity score.<br />The mean Galectin-3 level in patients with typical pneumonia was found to be significantly higher than those patients with atypical (p&lt;0.01) and indeterminate appearancseverity of lung involvement was significantly associated with Galectin-3 levels (p less then 0.01 r 0.76). Stepwise logistic regression model showed that the levels of ferritin (odds ratio [OR] = 0.05, p0.08) and Galectin-3 (OR = 0.1, p less then 0.01) were significantly and independently associated with typical pneumonia in COVID-19 patients. When COVID-19 patients were evaluated in terms of typical pneumonia, we determined a cut-off value of 18,9 ng/ml for Galectin-3 via ROC analysis. (87% sensitivity; 73% specificity; Area Under Curve (AUC) 0.89; p less then 0.001) Conclusion Galectin-3 was found as a diagnostic tool for COVID-19 associated typical pneumonia and as an indicator of both pneumonia and its severity.Background/aim Increased length of stay (LOS) in the palliative care unit (PCU) is a serious burden to the patients and the health care system. The predictors of longer LOS in a PCU have not been reported so far from Turkey. Our aim in this study was to evaluate the factors associated with the LOS in the PCU of a tertiary hospital. Materials and methods This cross-sectional analysis of a retrospective cohort evaluated adult patients' medical records admitted to the PCU between 2017 and 2019. The main inclusion criteria were four or more days of palliative unit stay and being home discharge during the study period. Data on demographics, chronic diseases, mobilization disability, route of feeding, tracheostomy, sleep disturbances, pressure ulcers, and antidepressant use were collected. Potential factors associated with prolonged LOS tertiles were examined by ordinal regression analysis. Results A total of 287 discharges from the PCU to home were analyzed. Mean (SD) age was 70.5 (15.8) years, and there was a mal LOS in the PCU in patients discharged home.<br />miRNAs control various biological functions such as cell proliferation, differentiation, signaling pathways, apoptosis and metabolism. Recently, it has been shown that there is a relationship between changes in miRNA expression and the development of acromegaly. Studies are needed to identify new disease-specific miRNAs. The aim of the current study is to evaluate plasma miR-29c-3p, miR-31-5p and miR-18a-5p steady-state levels in acromegaly. Another aim is to investigate whether there is a difference in the levels of these miRNAs in patients with inadequate control and controlled acromegaly with somatostatin analog (SSA) therapy. These miRNAs targeting the IGF-1 gene were determined by in silico estimation.<br />The study included 30 healthy controls (HC) and 20 patients with acromegaly. Anterior pituitary functions and disease activities of patients with acromegaly were evaluated at the time of study. The miR-29c-3p, miR-31-5p and miR-18a-5p levels were measured using quantitative Real-Time PCR (RT-qPCR).<br />The expression level of miR-29c-3p was significantly lower in patients with acromegaly compared to the HC group (p&lt;0.001). This downregulation was more pronounced in patients with inadequately controlled acromegaly than in patients with acromegaly controlled with SSA therapy (p=0.016). Univariate logistic regression analysis results showed that down regulation of miR-29c-3p expression increases the risk of developing acromegaly [OR (95% Cl)=1.605 (1.142-2.257), p=0.006]. There was no significant difference between the groups in terms of miR-31-5p and miR-18a-5p expression levels (p=0.375 and p=0.649, respectively).<br />Plasma miR-29c-3p expression level is downregulated in patients with acromegaly, and this is more pronounced in patients with inadequate control.<br />Plasma miR-29c-3p expression level is downregulated in patients with acromegaly, and this is more pronounced in patients with inadequate control.