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Vasopressor sparing and safety also were assessed. Mean arterial pressure response was achieved in 8 (88.9%) patients in the angiotensin II group compared with 0 (0%) patients in the placebo group (p = 0.0021). At hour 12, the median standard-of-care vasopressor dose had decreased from baseline by 76.5% in the angiotensin II group compared with an increase of 7.8% in the placebo group (p = 0.0013). No venous or arterial thrombotic events were reported.<br />Patients with vasoplegia after cardiac surgery with cardiopulmonary bypass rapidly responded to angiotensin II, permitting significant vasopressor sparing.<br />Patients with vasoplegia after cardiac surgery with cardiopulmonary bypass rapidly responded to angiotensin II, permitting significant vasopressor sparing.Patients undergoing heart transplant are at high risk for vasodilatory shock in the postoperative period, due to a combination of vascular dysfunction from end-stage heart failure and inflammatory response to cardiopulmonary bypass and, increasingly, long-term exposure to nonpulsatile blood flow in those who have received a left ventricular assist device as a bridge to transplant. Patients who have this vasoplegic syndrome, which may be refractory to traditional agents used in the treatment of shock, are vulnerable to organ dysfunction and death. Angiotensin II (ANG-2) is of increasing interest as an adjunct to traditional therapy, both for improvement in blood pressure and for sparing the use of high-dose catecholamine vasopressors. This case series describes the use of ANG-2 in 4 clinical scenarios for the treatment of shock due to heart transplant surgery, supporting its use in this role and justifying further prospective studies to clarify the appropriate place for ANG-2 in the hierarchy of adjunctive therapies.<br />Given the improved survival prediction of a tumor size-based 3-tier grouping system for stage IB cervical cancer under the new staging guidelines, this study examined the survival utility of a tumor size-based 3-tier system for stage T2a cervical cancer.<br />This is a population-based retrospective observational study utilizing the Surveillance, Epidemiology, and End Result Program from 1988 to 2016. Women with stage T2a/N0-1-x/M0-x cervical cancer were grouped by tumor size in a 3-tier system stage T2a (≤2cm), T2a (2.1-4.0cm), and T2a (&gt;4cm). Survival outcome was examined by non-proportional hazard analysis with restricted mean survival time (RMST) at 5 years.<br />Among 2449 cases, the most common group was T2a (&gt;4cm) (n=1,392, 56.8%), followed by T2a (2.1-4cm) (n=783, 32.0%) and T2a (≤2cm) (n=274, 11.2%). The median follow-up was 5.2 years. The proposed 3-tier system clearly discriminated survival outcome between the groups average overall survival time during 5 years of follow-up, 51.0, 47.2, and 43.8 months for T2a (≤2cm), T2a (2.1-4cm), and T2a (&gt;4cm) group, respectively (P&lt;0.001). Adjusted between-group difference of average overall survival time in the 3-tier system (8.8 months, 95% confidence interval [CI] 6.2-11.3, P&lt;0.001) was larger compared to the between-group difference in the historical 2-tier system (5.9 months, 95%CI 4.2-7.6, P&lt;0.001). Women in the T2a (≤2cm) group were more likely to have longer average overall survival time during 5 years of follow-up compared to those in the T2a (2.1-4cm) group (3.6 months, 95%CI 1.1-6.1, P=0.004).<br />Our study suggests that a tumor size-based 3-tier grouping system may be useful for improved prediction of survival in stage IIA cervical cancer.<br />Our study suggests that a tumor size-based 3-tier grouping system may be useful for improved prediction of survival in stage IIA cervical cancer.<br />Multicenter retrospective analysis of robotic partial nephrectomy for completely endophytic renal tumors (i.e. 3 points for the 'E' domain of the R.E.N.A.L. nephrometry score) was performed.<br />Patients' demographics, tumor characteristics, perioperative, functional, pathological and oncological data were analyzed and compared with those of patients with exophytic and mesophytic masses (i.e. 1 and 2 points for the 'E' domain, respectively). Multivariable logistic regression analysis was used to assess variables for trifecta achievement (negative margin, no postoperative complications, and 90% estimated glomerular filtration rate [eGFR] recovery).<br />Overall, 147 patients were included in the study group. Patients with a completely endophytic mass had bigger tumors (mean 4.2 vs. 4.1 vs. 3.2cm; p&lt;0.001) on preoperative imaging and higher overall R.E.N.A.L. score. There was no difference in mean operative time. Estimated blood loss was higher in the endophytic group (mean 177.75 vs. 185.5 vs. 130ml; p=0.001). Warm ischemia time was shorter for the exophytic group (median 16 vs. 21 vs. 22 min; p&lt;0.001). Postoperative complications were more frequent in patients with endophytic tumor (24.8% vs. 19.5% vs. [https://www.selleckchem.com/products/alpha-cyano-4-hydroxycinnamic-acid-alpha-chca.html α-cyano-4-hydroxycinnamic molecular weight] 14.8%; p&lt;0.001). Six (4.5%) patients had positive surgical margins, there was no difference between groups. Trifecta was achieved in 44 patients in endophytic group (45.4 vs. 68.8 and 50.9%, p&lt;0.001). Multivariable analysis for trifecta revealed that clinical tumor size (odds ratio 0.667, 95% confidence interval 0.56-0.79, p&lt;0.001) was only significant predictor for trifecta achievement.<br />Our findings confirm that RAPN in case of completely endophytic renal masses can be performed with acceptable outcomes in centers with significant robotic expertise.<br />Our findings confirm that RAPN in case of completely endophytic renal masses can be performed with acceptable outcomes in centers with significant robotic expertise.<br />Despite rigorous and multiple attempts to establish a culture of patient safety and a goal to decrease incidence of patient deaths in the health care, estimations of preventable mortality due to medical errors varied widely from 44,000 to 250,000 in hospital settings. This magnitude of medical errors establishes patient safety as being at the forefront of public concerns, healthcare practice and research. In addition to the potential negative impact on patients and the healthcare system, medical errors evoke intense psychological responses in health care providers' responses that threaten their personal and professional selves, and their ability to deliver high quality patient care. Studies show half of all hospital providers will suffer from second victim phenomena at least once in their careers. Health care institutions have begun a paradigm shift from blame to fairness, referred to as 'just culture'. 'Just culture' better ensures that a balanced, responsible approach for both providers who err and healthcare organizations in which they practice, and shifts the focus to designing improved systems in the workplace.