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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are usually characterized by a focus on the practical aspects of the study design, such as recruitment and consent as well as adherence to the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from various geographical areas. This type of heterogeneity, which is vital for pragmatic trials to be valid and lessen the chance of bias, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.
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Legality
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The aim of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. They are usually commissioned by policymakers and practitioners to help inform their decisions. They can be used to determine the causal relationship between an intervention and its effects. However, they should not be used as a substitute for explanation trials.
The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study which includes recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the subject of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.