Difference between revisions of "Goldilocks mastectomy"

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Finally, the network model is quantitatively analyzed by evaluation indexes from the perspective of bionics. The experimental results show that the DBN network, LeNet5 network, and BP network have synchronous characteristics. And the DBN network and LeNet5 network have certain chaotic characteristics, but there is still a certain distance between the three classical neural networks and actual biological neural networks. The KIII model has certain small-world characteristics in structure, and its network also exhibits synchronization characteristics and chaotic characteristics. Compared with the DBN network, LeNet5 network, and the BP network, the KIII model is closer to the real biological neural network.Visceral leishmaniasis (VL) infection is mostly caused by Leishmania donovani and affects countries worldwide. Despite the need for a safe and effective vaccine against leishmaniasis due to the increased drug resistance, however, no vaccine has yet been licensed for clinical use. This study revolves around the immunoinformatics approach to design a multi-epitope vaccine against VL infection. In this case, the proteome of L. donovani has been investigated, and three host non-homologous and antigenic extracellular secretory proteins have been identified as potential vaccine candidates with low transmembrane helices (≤ 1). The multi-epitope subunit vaccine construct consists of T-cell (cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte (HTL)) epitopes accompanied by appropriate adjuvant and linkers. A 372-amino acid vaccine construct has been established with specific characteristics, such as soluble, stable, antigenic, non-allergenic, non-toxic, and non-host homologous. Besides, the tertiary structure of the designed vaccine was modeled and validated. Also, the stability and affinity of the vaccine- TLR4 complex were confirmed by using molecular docking and molecular dynamics (MD) simulation. In addition, in silico immunization assay showed the efficiency of this candidate vaccine to stimulate an effective immune response. Furthermore, the refined vaccine was optimized and cloned in the pET28a (+) vector, and its successful expression was confirmed virtually. However, the experimental validation is required to verify the multi-epitope vaccine efficacy against VL infection.The structural consequences of ongoing mutations on the SARS-CoV-2 spike-protein remains to be fully elucidated. These mutations could change the binding affinity between the virus and its target cell. Moreover, obtaining new mutations would also change the therapeutic efficacy of the designed drug candidates. To evaluate these consequences, 3D structure of a mutant spike protein was predicted and checked for stability, cavity sites, and residue depth. The docking analyses were performed between the 3D model of the mutated spike protein and the ACE2 protein and an engineered therapeutic ACE2 against COVID-19. The obtained results revealed that the N501Y substitution has altered the interaction orientation, augmented the number of interface bonds, and increased the affinity against the ACE2. On the other hand, the P681H mutation contributed to the increased cavity size and relatively higher residue depth. The binding affinity between the engineered therapeutic ACE2 and the mutant spike was significantly higher with a distinguished binding orientation. It could be concluded that the mutant spike protein increased the affinity, preserved the location, changed the orientation, and altered the interface amino acids of its interaction with both the ACE2 and its therapeutic engineered version. The obtained results corroborate the more aggressive nature of mutated SARS-CoV-2 due to their higher binding affinity. Moreover, designed ACe2-baased therapeutics would be still highly effective against covid-19, which could be the result of conserved nature of cellular ACE2.<br />The online version contains supplementary material available at 10.1007/s10989-021-10346-1.<br />The online version contains supplementary material available at 10.1007/s10989-021-10346-1.Secondary pulmonary tuberculosis (SPT) is one of the top ten causes of death from a single infectious agent. To recognize SPT more accurately, this paper proposes a novel artificial intelligence model, which uses Pseudo Zernike moment (PZM) as the feature extractor and deep stacked sparse autoencoder (DSSAE) as the classifier. In addition, 18-way data augmentation is employed to avoid overfitting. This model is abbreviated as PZM-DSSAE. The ten runs of 10-fold cross-validation show this model achieves a sensitivity of 93.33% ± 1.47%, a specificity of 93.13% ± 0.95%, a precision of 93.15% ± 0.89%, an accuracy of 93.23% ± 0.81%, and an F1 score of 93.23% ± 0.83%. The area-under-curve reaches 0.9739. This PZM-DSSAE is superior to 5 state-of-the-art approaches.B-cell epitope prediction research has received growing interest since the development of the first method. B-cell epitope identification with the aid of an accurate prediction method is one of the most important steps in epitope-based vaccine development, immunodiagnostic testing, antibody production, disease diagnosis, and treatment. Nevertheless, using experimental methods in epitope mapping is very time-consuming, costly, and labor-intensive. Therefore, although successful predictions with in silico methods are very important in epitope prediction, there are limited studies in this area. The aim of this study is to propose a new approach for successfully predicting B-cell epitopes for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, the SARS-CoV B-cell epitope prediction performances of different fuzzy learning classification models genetic cooperative competitive learning (GCCL), fuzzy genetics-based machine learning (GBML), Chi's method (CHI), Ishibuchi's method with weight fe outbreaks of the coronavirus family, especially SARS-CoV-2 and its possible mutations.The most prevalent cause of mortality and morbidity worldwide is acute coronary syndrome (ACS) and its consequences. Exposure to particulate matter (PM) from air pollution has been shown to impair both. Various plausible pathogenic mechanisms have been identified, including microRNAs (miRNAs), an epigenetic regulator for gene expression. Endogenous miRNAs, average 22-nucleotide RNAs (ribonucleic acid), regulate gene expression through mRNA cleavage or translation repression and can influence proinflammatory gene expression posttranscriptionally. However, little is known about miRNA responses to fine PM (PM2.5, PM10, ultrafine particles, black carbon, and polycyclic aromatic hydrocarbon) from air pollution and their potential contribution to cardiovascular consequences, including systemic inflammation regulation. For the past decades, microRNAs (miRNAs) have emerged as novel, prospective diagnostic and prognostic biomarkers in various illnesses, including ACS. We wanted to outline some of the most important studies in the field and address the possible utility of miRNAs in regulating particulate matter-induced ACS (PMIA) on inflammatory factors in this review.Wearing surgical masks remains the most effective protective measure against COVID-19 before mass vaccination, but insufficient comfortability and low antibacterial/antiviral activities accelerate the replacement frequency of surgical masks, resulting in large amounts of medical waste. To solve this problem, we report new nanofiber membrane masks with outstanding comfortability and anti-pathogen functionality prepared using fluorinated carbon nanofibers/carbon fiber (F-CNFs/CF). This was used to replace commercial polypropylene (PP) nonwovens as the core layer of face masks. The through-plane and in-plane thermal conductivity of commercial PP nonwovens were only 0.12 and 0.20 W/m K, but the F-CNFs/CF nanofiber membranes reached 0.62 and 5.23 W/m K, which represent enhancements of 380% and 2523%, respectively. The surface temperature of the PP surgical masks was 23.9 ℃ when the wearing time was 15 min, while the F-CNFs/CF nanocomposite fibrous masks reached 27.3 ℃, displaying stronger heat dissipation. Moreover, the F-CNFs/CF nanofiber membranes displayed excellent electrical conductivity and produced a high-temperature layer that killed viruses and bacteria in the masks. The surface temperature of the F-CNFs/CF nanocomposite fibrous masks reached 69.2 ℃ after being connected to a portable power source for 60 s. Their antibacterial rates were 97.9% and 98.6% against E. coli and S. aureus, respectively, after being connected to a portable power source for 30 min.Imperial County, California, is a high-need, medically underserved area that has some of the worst overall health outcomes of all California counties. Given this and the high depression and anxiety rates in agricultural occupations, Imperial County farmers and ranchers may be at an increased risk of stress and poor mental health outcomes. An exploratory mixed methods assessment was used to collect information from 24 farmers and ranchers in Imperial County. Survey topics included questions about farm or ranch operations, farm-related stress, mental health, community support, and health behaviors. [https://www.selleckchem.com/products/gw806742x.html GW806742X concentration] The results indicate that most respondents perceive unpredictable factors, such as government regulations, as the most impactful stressors related to their farm or ranch operations. Additionally, depression symptomatology scores were positively correlated with respondents' ability to obtain credit. Efforts to understand farm-related stress and how community support can help Imperial County farmers and ranchers mediate adverse physical and mental health effects through formal and informal networks are considered.Detection and quantification of biotargets are important analytical tasks, which are solved using a wide range of various methods. In recent years, methods based on the isothermal amplification of nucleic acids (NAs) have been extensively developed. Among them, a special place is occupied by rolling circle amplification (RCA), which is used not only for the detection of a specific NA but also for the analysis of other biomolecules, and is also a versatile platform for the development of highly sensitive methods and convenient diagnostic devices. The present review reveals a number of methodical aspects of RCA-mediated analysis; in particular, the data on its key molecular participants are presented, the methods for increasing the efficiency and productivity of RCA are described, and different variants of reporter systems are briefly characterized. Differences in the techniques of RCA-mediated analysis of biotargets of various types are shown. Some examples of using different RCA variants for the solution of specific diagnostic problems are given.Azaadamantanes are nitrogen-containing analogs of adamantane, which contain one or more nitrogen atoms instead of carbon atoms. This substitution leads to several specific chemical and physical properties. The azaadamantane derivatives have less lipophilicity compared to their adamantane analogs, which affects both their interaction with biological targets and bioavailability. The significant increase in the number of publications during the last decade (2009-2020) concerning the study of reactivity and biological activity of azaadamantanes and their derivatives indicates a great theoretical and practical interest in these compounds. Compounds with pronounced biological activity have been already discovered among azaadamantane derivatives. The review is devoted to the biological activity of azaadamantanes and their derivatives. It presents the main methods for the synthesis of di- and triazaadamantanes and summarizes the accumulated data on studying the biological activity of these compounds. The prospects for the use of azaadamantanes in medical chemistry and pharmacology are discussed.
0 and 0.42 mg kg-1 dw, respectively), while L. scabrum and M. procera a source of Cu. Consumption of the studied mushrooms would not lead to significant exposure to Al, As, Cr, or Ni. Considering that wild mushrooms will continue to be collected in Poland, one should bear in mind that they are a limited source of minerals in the human diet while their frequent, regular consumption, associated with exposure to selected toxic elements, should not be recommended.Both organic and inorganic precursors play important roles in the formation and speciation of disinfection by-products (DBPs). This study aimed to investigate the efficacy of three different anion exchange resins for removing both organic and inorganic DBP precursors simultaneously in a single treatment system. Resins in the single (Purolite®-Br, MIEX®-Br, and MIEX®-Gold) and mixed (Purolite®-Br with MIEX®-Gold and MIEX®-Br with MIEX®-Gold) application modes were tested and compared for the removal of dissolved organic carbon (DOC), bromide (Br-), and iodide (I-) from a raw source water and a treated wastewater effluent. Uniform formation condition (UFC) tests were conducted to measure the concentrations of trihalomethanes (THM4), haloacetic acids (HAA9), haloacetonitriles (HAN6), and total organic halides (TOX) total organic chlorine (TOCl), total organic bromine (TOBr), and total organic iodine (TOI) before and after the anion exchange resin treatments. The anion exchange treatment substantially lowered the DOC, UV254 absorbing matter, dissolved nitrogen (DN), Br-, and I-. Consequently, the formation of THM4, HAA9, HAN6, and TOX in the examined chlorinated water samples were reduced significantly. The maximum reduction in THM4 and TOX (66-69% and 61%, respectively) from wastewater effluent was achieved by the mixed resin system, which also reduced the THM4 and TOX by 77% and 77%, respectively, from raw source water. Overall, mixed resin systems (a DOC-selective and a Br-selective resin) resulted in lower amounts of THM4 and HAA9 formation during subsequent chlorination with lower bromine incorporation as compared to single resin systems. Furthermore, they exhibited lower TOBr formation, while TOI formation was not detected.In this study, bamboo residues derived functional hydrochar microspheres have been fabricated by different acids-assisted hydrothermal carbonization including hydrochloric aicd, sulfuric acid or nitric acid.The energy-dispersive X-ray fluorescence spectroscopy and Fourier Transform Infrared spectroscopy analyses showed that sulfur- and nitrogen-containing functional groups were grafted on the surface of hydrochar microspheres, respectively. Elemental analysis indicates that the addition of acids has a significant influence on the hydrothermal reaction pathway and promotes the hydrolysis process. When the hydrothermal carbonization temperature is 220 °C, hydrochloric acid and nitric acid can effectively overcome the agglomeration of hydrochar microspheres and form single micron carbon sphere. Irregularly shaped hydrochar particles groups were formed during sulfuric acid-assisted hydrothermal treatment. The results indicate the viability of acid assisted hydrothermal carbonization to produce the functional hydrochar microsphere using bamboo residues.An efficient iron-manganese modified biochar (FMBC) was successfully synthesized as a heterogeneous Fenton-like catalyst through easy post-modification and applied for degradation of benzene, toluene, ethylbenzene, xylene isomers (ortho, para, and meta), and styrene (BTEXS) in the presence of H2O2. The catalyst was characterized by Brunauer-Emmett-Teller method, scanning electron microscopy, and X-ray photoelectron spectrometry. The effects of H2O2 concentration, FMBC dose, and initial pH on BTEXS degradation were also investigated. Results showed that degradation efficiency of FMBC for individual BTEXS varied from 83.05% to 94.12% in 3 h. Kinetic analysis showed that a first-order kinetic model with respect to BTEXS concentration could be used to explain the BTEXS degradation for FMBC/H2O2 system. The degradation reaction was more suitable in a wide pH range (3-10) than those in previous studies, thereby overcoming the low-efficiency problem of conventional Fenton reaction at high pH. Moreover, the doses of FMBC and H2O2 are a crucial factor affecting BTEXS degradation. Radical scavenger experiments revealed that ∙OH, ∙O2-, and 1O2 participated in the degradation process, and ∙OH was the major contributor. The synthesized catalyst is durable with stable BTEXS removal efficiency after seven consecutive cycles. The removal efficiency of BTEXS by FMBC in produced water reached 93.23% in 12 h, indicating FMBC has practical value.We investigated the adsorption mechanisms for removing fluoride based on experimental and modeling studies. Lanthanum-aluminum perovskite was designed for treating wastewater contaminated by fluoride. A fluorine-species model was developed to calculate the concentrations of different species of fluorine F-, HF, HF2-. Multiple kinetic models were examined and the pseudo-second order model was found the best to fit the experimental data, implying fast-chemisorption. The thermodynamic data were fitted by the Langmuir model and Freundlich model at different temperatures, indicating heterogeneous adsorption at low temperature and homogeneous adsorption at high temperature. The La2Al4O9 material had less influence from negative ions when adsorbing fluoride. The adsorption mechanisms were further studied using experiments and Density Functional Theory calculations. The adsorption experiments could be attributed to the lattice plane (1 2 1) and La, O, Al sites. More Al sites were required than La sites for the increase of fluoride concentration. By contrast, more La sites than Al sites were needed for increased pH.Highly ordered periodic mesoporous organosilica (PMO) with large-pores (9.3 nm) synthesized using novel and cost-effective route. The synthesized PMO was then functionalized by p-phenylenediamine (PPD) and incorporated in polyethersulfone (PES) nanofiltration membrane with various dosage using phase inversion method. The prepared membranes were characterized with FT-IR/ATR, FE-SEM and EDX techniques. The overall porosity, the mean of pore radius, water contact angle, fouling, permeation, and rejection were computed. As a result, the hydrophilicity and the pure water flux of membranes were significantly enhanced after modification with PMO-PPD due to its high hydrophilic nature as nanofiller. Ultimately, the modified membrane with 0.25 wt% of PPD was found the ideal membrane with water contact angle of 54.2%, pure water flux of 33.7 L/m2 h, porosity of 74.1%, and mean pore radius of 4.96 nm. This membrane showed the maximum increase in water flux and superlative anti-fouling growth when compared to the other studied membranes. Moreover, among modified membranes with various quantity of PPD, the performance of the PES-PMO-PPD 0.25 wt% was the best for rejection of MO dye (96.7%), Pb(II) (93.1%), Na2SO4 (73.0%), MgSO4 (41.6%), and NaCl (33.7%).Polystyrene foam (expanded and extruded polystyrene EPS and XPS, respectively) is a ubiquitous and pervasive type of marine plastic whose physical properties, transport and fate are distinctly different to those of other common (unfoamed) types of thermoplastic litter. In this study, a range of fragments of EPS and XPS retrieved from three beaches in southwest England have been characterised by energy-dispersive X-ray fluorescence (XRF) spectrometry in order to examine the chemical makeup and potential biological and geochemical impacts and interactions of this type of plastic waste. Analyses performed through sample faces and, in some cases and after dissection, through the material core, revealed variable concentrations of Fe, Ti and Zn among the fragments and, in many instances, within the same sample. [https://www.selleckchem.com/products/sgi-110.html selleckchem] This likely reflects the presence of reaction residues and pigments arising from the manufacture of polystyrene, and, for Fe and Ti, significant and heterogeneous ion and mineral acquisition from the environment during transport in suspension or while beached. Acquired oxides of Fe are partly responsible for the chemical fouling observed on the face of most samples and are able to act as an adsorbent for other metals, like Pb. Detection of Br in many fragments up to concentrations of 11,500 mg kg-1 likely results from the incorporation of the flame retardant, hexabromocyclododecane, in EPS and XPS designed for (but not necessarily limited to) the construction sector. These observations suggest that EPS and XPS can act as both a source and sink for contaminants in the marine environment that merit further investigation.Polychlorinated dioxins and dibenzofurans (PCDD/Fs) are highly toxic contaminants that are strictly regulated and monitored in the environment and food to reduce human exposure. Recently, the increasing occurrence of polybrominated dioxins and dibenzofurans (PBDD/Fs) in the environment is raising concerns about the impact on human health by the combined exposure to chlorinated and brominated analogues of dioxins. Toxicological properties of PBDD/Fs relative to PCDD/Fs have not been firmly established, and brominated dioxins are not included in routine monitoring programs. In this study, we set out to determine human-relevant congener-specific potency values for a range of brominated and chlorinated dioxin congeners, based on their aryl hydrocarbon receptor (AhR)-mediated mode of toxic action. Transactivation of the AhR was measured using dioxin-responsive (DR) CALUX reporter gene assays. Because of known species-differences in dioxin-mediated toxicity, we developed and used a HepG2 human liver cell-based DR human CALUX assay that is a variant of the rodent-based DR CALUX. The assay was found to be highly inducible and stable, with low variations between independent measurements. Using both DR CALUX assays in an automated high-throughput mode we found that overall PBDD/Fs were as potent as PCDD/Fs in inducing AhR transactivation, but congener-specific differences were observed. We also observed species-specific differences in sensitivity and potency when comparing DR human REP values to those obtained in the rat-based DR CALUX. Finally, we observed significant differences between WHO-TEF values and DR human REP values, suggesting that actual WHO-TEF values may underestimate the hazards associated with exposure of humans to dioxins.Soil contaminated by combinations of heavy metals and organic pollutants has become an increasingly prominent environmental issue. Developing efficient technologies to synchronously decontaminate such co-contaminated sites is challenging and imperative. In our previous study for the treatment of Copper (Cu) and pyrene contaminated soil, electrokinetics (EK) coupled acidic permanganate (PM) performed best for degradation of pyrene near the injection spot, but it unfortunately prevented the migration of Cu. In order to further enhance the removal efficiency of these contaminants, in this study, batch experiments were conducted to investigate the feasibility of delivering PM by EK under regular refreshment of acidoxidant along with amplification of voltage gradient. The results showed that PM can be transported from cathode to anode to S2 section (near the anode) with a slow mass transfer rate via electromigration and reversed electroosmotic flow, and further delivery was achieved when Cu and pyrene were coexisted.

Latest revision as of 18:21, 10 October 2024

0 and 0.42 mg kg-1 dw, respectively), while L. scabrum and M. procera a source of Cu. Consumption of the studied mushrooms would not lead to significant exposure to Al, As, Cr, or Ni. Considering that wild mushrooms will continue to be collected in Poland, one should bear in mind that they are a limited source of minerals in the human diet while their frequent, regular consumption, associated with exposure to selected toxic elements, should not be recommended.Both organic and inorganic precursors play important roles in the formation and speciation of disinfection by-products (DBPs). This study aimed to investigate the efficacy of three different anion exchange resins for removing both organic and inorganic DBP precursors simultaneously in a single treatment system. Resins in the single (Purolite®-Br, MIEX®-Br, and MIEX®-Gold) and mixed (Purolite®-Br with MIEX®-Gold and MIEX®-Br with MIEX®-Gold) application modes were tested and compared for the removal of dissolved organic carbon (DOC), bromide (Br-), and iodide (I-) from a raw source water and a treated wastewater effluent. Uniform formation condition (UFC) tests were conducted to measure the concentrations of trihalomethanes (THM4), haloacetic acids (HAA9), haloacetonitriles (HAN6), and total organic halides (TOX) total organic chlorine (TOCl), total organic bromine (TOBr), and total organic iodine (TOI) before and after the anion exchange resin treatments. The anion exchange treatment substantially lowered the DOC, UV254 absorbing matter, dissolved nitrogen (DN), Br-, and I-. Consequently, the formation of THM4, HAA9, HAN6, and TOX in the examined chlorinated water samples were reduced significantly. The maximum reduction in THM4 and TOX (66-69% and 61%, respectively) from wastewater effluent was achieved by the mixed resin system, which also reduced the THM4 and TOX by 77% and 77%, respectively, from raw source water. Overall, mixed resin systems (a DOC-selective and a Br-selective resin) resulted in lower amounts of THM4 and HAA9 formation during subsequent chlorination with lower bromine incorporation as compared to single resin systems. Furthermore, they exhibited lower TOBr formation, while TOI formation was not detected.In this study, bamboo residues derived functional hydrochar microspheres have been fabricated by different acids-assisted hydrothermal carbonization including hydrochloric aicd, sulfuric acid or nitric acid.The energy-dispersive X-ray fluorescence spectroscopy and Fourier Transform Infrared spectroscopy analyses showed that sulfur- and nitrogen-containing functional groups were grafted on the surface of hydrochar microspheres, respectively. Elemental analysis indicates that the addition of acids has a significant influence on the hydrothermal reaction pathway and promotes the hydrolysis process. When the hydrothermal carbonization temperature is 220 °C, hydrochloric acid and nitric acid can effectively overcome the agglomeration of hydrochar microspheres and form single micron carbon sphere. Irregularly shaped hydrochar particles groups were formed during sulfuric acid-assisted hydrothermal treatment. The results indicate the viability of acid assisted hydrothermal carbonization to produce the functional hydrochar microsphere using bamboo residues.An efficient iron-manganese modified biochar (FMBC) was successfully synthesized as a heterogeneous Fenton-like catalyst through easy post-modification and applied for degradation of benzene, toluene, ethylbenzene, xylene isomers (ortho, para, and meta), and styrene (BTEXS) in the presence of H2O2. The catalyst was characterized by Brunauer-Emmett-Teller method, scanning electron microscopy, and X-ray photoelectron spectrometry. The effects of H2O2 concentration, FMBC dose, and initial pH on BTEXS degradation were also investigated. Results showed that degradation efficiency of FMBC for individual BTEXS varied from 83.05% to 94.12% in 3 h. Kinetic analysis showed that a first-order kinetic model with respect to BTEXS concentration could be used to explain the BTEXS degradation for FMBC/H2O2 system. The degradation reaction was more suitable in a wide pH range (3-10) than those in previous studies, thereby overcoming the low-efficiency problem of conventional Fenton reaction at high pH. Moreover, the doses of FMBC and H2O2 are a crucial factor affecting BTEXS degradation. Radical scavenger experiments revealed that ∙OH, ∙O2-, and 1O2 participated in the degradation process, and ∙OH was the major contributor. The synthesized catalyst is durable with stable BTEXS removal efficiency after seven consecutive cycles. The removal efficiency of BTEXS by FMBC in produced water reached 93.23% in 12 h, indicating FMBC has practical value.We investigated the adsorption mechanisms for removing fluoride based on experimental and modeling studies. Lanthanum-aluminum perovskite was designed for treating wastewater contaminated by fluoride. A fluorine-species model was developed to calculate the concentrations of different species of fluorine F-, HF, HF2-. Multiple kinetic models were examined and the pseudo-second order model was found the best to fit the experimental data, implying fast-chemisorption. The thermodynamic data were fitted by the Langmuir model and Freundlich model at different temperatures, indicating heterogeneous adsorption at low temperature and homogeneous adsorption at high temperature. The La2Al4O9 material had less influence from negative ions when adsorbing fluoride. The adsorption mechanisms were further studied using experiments and Density Functional Theory calculations. The adsorption experiments could be attributed to the lattice plane (1 2 1) and La, O, Al sites. More Al sites were required than La sites for the increase of fluoride concentration. By contrast, more La sites than Al sites were needed for increased pH.Highly ordered periodic mesoporous organosilica (PMO) with large-pores (9.3 nm) synthesized using novel and cost-effective route. The synthesized PMO was then functionalized by p-phenylenediamine (PPD) and incorporated in polyethersulfone (PES) nanofiltration membrane with various dosage using phase inversion method. The prepared membranes were characterized with FT-IR/ATR, FE-SEM and EDX techniques. The overall porosity, the mean of pore radius, water contact angle, fouling, permeation, and rejection were computed. As a result, the hydrophilicity and the pure water flux of membranes were significantly enhanced after modification with PMO-PPD due to its high hydrophilic nature as nanofiller. Ultimately, the modified membrane with 0.25 wt% of PPD was found the ideal membrane with water contact angle of 54.2%, pure water flux of 33.7 L/m2 h, porosity of 74.1%, and mean pore radius of 4.96 nm. This membrane showed the maximum increase in water flux and superlative anti-fouling growth when compared to the other studied membranes. Moreover, among modified membranes with various quantity of PPD, the performance of the PES-PMO-PPD 0.25 wt% was the best for rejection of MO dye (96.7%), Pb(II) (93.1%), Na2SO4 (73.0%), MgSO4 (41.6%), and NaCl (33.7%).Polystyrene foam (expanded and extruded polystyrene EPS and XPS, respectively) is a ubiquitous and pervasive type of marine plastic whose physical properties, transport and fate are distinctly different to those of other common (unfoamed) types of thermoplastic litter. In this study, a range of fragments of EPS and XPS retrieved from three beaches in southwest England have been characterised by energy-dispersive X-ray fluorescence (XRF) spectrometry in order to examine the chemical makeup and potential biological and geochemical impacts and interactions of this type of plastic waste. Analyses performed through sample faces and, in some cases and after dissection, through the material core, revealed variable concentrations of Fe, Ti and Zn among the fragments and, in many instances, within the same sample. selleckchem This likely reflects the presence of reaction residues and pigments arising from the manufacture of polystyrene, and, for Fe and Ti, significant and heterogeneous ion and mineral acquisition from the environment during transport in suspension or while beached. Acquired oxides of Fe are partly responsible for the chemical fouling observed on the face of most samples and are able to act as an adsorbent for other metals, like Pb. Detection of Br in many fragments up to concentrations of 11,500 mg kg-1 likely results from the incorporation of the flame retardant, hexabromocyclododecane, in EPS and XPS designed for (but not necessarily limited to) the construction sector. These observations suggest that EPS and XPS can act as both a source and sink for contaminants in the marine environment that merit further investigation.Polychlorinated dioxins and dibenzofurans (PCDD/Fs) are highly toxic contaminants that are strictly regulated and monitored in the environment and food to reduce human exposure. Recently, the increasing occurrence of polybrominated dioxins and dibenzofurans (PBDD/Fs) in the environment is raising concerns about the impact on human health by the combined exposure to chlorinated and brominated analogues of dioxins. Toxicological properties of PBDD/Fs relative to PCDD/Fs have not been firmly established, and brominated dioxins are not included in routine monitoring programs. In this study, we set out to determine human-relevant congener-specific potency values for a range of brominated and chlorinated dioxin congeners, based on their aryl hydrocarbon receptor (AhR)-mediated mode of toxic action. Transactivation of the AhR was measured using dioxin-responsive (DR) CALUX reporter gene assays. Because of known species-differences in dioxin-mediated toxicity, we developed and used a HepG2 human liver cell-based DR human CALUX assay that is a variant of the rodent-based DR CALUX. The assay was found to be highly inducible and stable, with low variations between independent measurements. Using both DR CALUX assays in an automated high-throughput mode we found that overall PBDD/Fs were as potent as PCDD/Fs in inducing AhR transactivation, but congener-specific differences were observed. We also observed species-specific differences in sensitivity and potency when comparing DR human REP values to those obtained in the rat-based DR CALUX. Finally, we observed significant differences between WHO-TEF values and DR human REP values, suggesting that actual WHO-TEF values may underestimate the hazards associated with exposure of humans to dioxins.Soil contaminated by combinations of heavy metals and organic pollutants has become an increasingly prominent environmental issue. Developing efficient technologies to synchronously decontaminate such co-contaminated sites is challenging and imperative. In our previous study for the treatment of Copper (Cu) and pyrene contaminated soil, electrokinetics (EK) coupled acidic permanganate (PM) performed best for degradation of pyrene near the injection spot, but it unfortunately prevented the migration of Cu. In order to further enhance the removal efficiency of these contaminants, in this study, batch experiments were conducted to investigate the feasibility of delivering PM by EK under regular refreshment of acidoxidant along with amplification of voltage gradient. The results showed that PM can be transported from cathode to anode to S2 section (near the anode) with a slow mass transfer rate via electromigration and reversed electroosmotic flow, and further delivery was achieved when Cu and pyrene were coexisted.

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