Difference between revisions of "Tiziana Fuoco"

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05).<br />Successful hip and knee arthroplasty operations improve patients' health-related quality of life. According to this study, hip arthroplasty improves the health-related quality of life more than knee arthroplasty.<br />Successful hip and knee arthroplasty operations improve patients' health-related quality of life. According to this study, hip arthroplasty improves the health-related quality of life more than knee arthroplasty.The objective was to compare lower extremity inter-segment coordination between high-calibre and low-calibre ice hockey players during forward full stride skating. A 10-camera Vicon motion capture system collected kinematic data on male high-calibre (n = 8) and low-calibre (n = 8) participants. Continuous relative phase (CRP) was calculated for shank-sagittal/thigh-sagittal, shank-sagittal/thigh-frontal and foot-sagittal/shank-sagittal segment pairs. Principal component analysis (PCA) was used to extract features of greatest variability of the CRP and hierarchical linear model investigated relationships between principal components and skill level. High-calibre players demonstrated more out-of-phase coordination (higher CRP) of shank-sagittal/thigh-sagittal throughout glide/push-off (p = 0.011) as well as a delay in the transition to more in-phase coordination during early recovery phase (p = 0.014). For shank-sagittal/thigh-frontal (p = 0.013), high-calibre players had more out-of-phase coordination throughout the entire stride. High-calibre players were also associated with an earlier transition to more out-of-phase coordination of the foot-sagittal/shank-sagittal during push-off (p = 0.007) and a smaller difference in CRP between mid-glide/early recovery (p = 0.016). Utilising more out-of-phase modes of coordination may allow players to more easily adjust to optimal modes of coordination throughout skating strides. Skating drills incorporating varying speed, directionality and external stimuli may encourage the development of more optimal coordination during skating.<br />A number of studies have previously been published on the benefits of GP appraisal. Ours is the first study that compares the views of doctors registered before and after the introduction of appraisals on various core elements of the appraisal process.<br />This study aimed to explore potential differences, between GPs qualifying before and those after the introduction of NHS appraisals, on the utility of the appraisal process. Additionally, to discover the perceived impact of appraisals on interaction with colleagues and patients.<br />Suffolk appraisers were recruited to distribute a paper questionnaire, in two sections, for each appraisal undertaken over a 12-month period. The first part of the questionnaire related to that specific appraisal. The second part, seven questions using Likert scales and free-text comments, asked about the appraisal process in general. [https://www.selleckchem.com/products/GDC-0449.html https://www.selleckchem.com/products/GDC-0449.html] The feedback from the second part forms the data for this study.<br />Overall, doctors tended to agree that appraisals had a beneficial impact in the core areas investigated. However, there was a significant difference between generations those registered before 1998 were less likely to find NHS appraisals beneficial. Both groups reported that preparation took up too much time. Opinions regarding the impact of appraisals on interaction were evenly divided amongst appraisees, with the older cohort more likely to report negatively.<br />There is a generational difference amongst GP in the perceived utility of NHS appraisal. Current plans to redesign the process to make appraisals less onerous will be welcomed by both groups.<br />There is a generational difference amongst GP in the perceived utility of NHS appraisal. Current plans to redesign the process to make appraisals less onerous will be welcomed by both groups.Purpose Nowadays chronicity is one of the most frequent aspects of care doctors have to deal with. Students need to know and learn clinical, relational, social and managerial elements of chronicity and changes that disease causes in patients, families and doctors themselves. Methods Students are supervised by a family doctor, in taking care of 'their' patient and of his/her family. They are asked to keep an updated diary, participate in the periodical revision of the medical history and write an end-report. Two focus groups were conducted, adopting a constructive qualitative approach in order to analyse results. Results The focus groups and the SWOT analysis show common themes such as innovative learning and multidisciplinary approach. Clinical evolution of the disease, mental and body changes and the diagnostic and therapeutic future planning were also revealed. Conclusions The main goal of this innovation was understanding the importance of a continuous clinical relationship and of the role of the doctor as 'therapy itself'. The project was demonstrated to be able to teach the future physicians how to practice more empathetic medicine and to improve the skills needed in a complex relational environment including that of chronic disease.In this study, three strains of lactobacilli and bifidobacteria originally isolated from healthy infants, were tested for their abilities to activate RAW264.7 cells. Gene expression and cytokine production of interleukin-10 (IL-10) of RAW264.7 cells were evaluated. The activation of extracellular regulated protein kinases 1/2 (ERK1/2), p38, and nuclear factor-κB (NK-κB) were also assessed. These results suggest lactobacilli and bifidobacteria in infants may promote production of IL-10 in macrophages, conferring a protective effect in hosts suffering from inflammation. Dimerization of TLR2 and MyD88 and subsequent phosphorylation of the key downstream signaling molecules, such as MAPKs and NK-κB, may be one of the key underlying mechanisms of activation of macrophages by these microbes. Bifidobacteria and lactobacilli induced macrophages to secrete IL-10 in a different manner, which may relate to their abilities to activate key signaling pathways mediated by TLR2 and MyD88.Resveratrol is a natural polyphenol with beneficial antioxidant properties. It suppresses the migration of osteoblast-like MC3T3-E1 cells induced by epidermal growth factor, via SIRT1-mediated inhibition of SAPK/JNK and Akt. Moreover, insulin-like growth factor-I (IGF-I) stimulates the migration involving the pathways of p44/p42 mitogen-activated protein (MAP) kinase and Akt. Therefore, we investigated the effects of resveratrol on IGF-I-induced cell migration. Resveratrol and SRT1720, an activator of SIRT1, suppressed IGF-I-induced migration. Inauhzin, a SIRT1 inhibitor, significantly rescued the inhibition of IGF-I-induced cell migration by resveratrol. Resveratrol inhibited IGF-I-induced phosphorylation of p44/p42 MAP kinase but not Akt. SRT1720 inhibited IGF-I-induced phosphorylation of p44/p42 MAP kinase. Furthermore, PD98059, p44/p42 MAP kinase inhibitor, alone suppressed IGF-I-induced osteoblast migration, but did not affect the suppressive effect of resveratrol when administered concomitantly. These findings strongly suggest that resveratrol suppresses IGF-I-induced osteoblast migration via SIRT1 activation at least partially by attenuating the p44/p42 MAP kinase pathway.
This paper, based on different sources of information and an extensive database of water related data, collects, evaluates and groups data from a quantity and quality point of view for all the different water bodies of Greece. Specific water districts such as the Aegean islands, the eastern part of Crete, Attica and Thessaly are expected to be the most affected by climate-water impacts with reduced crops yields, a greater risk of droughts and/or floods, a loss of agricultural land, declining water availability, and degraded water resources (surface and groundwater). Based on these findings, the proposed review highlights agricultural adaptation practices for increasing water use efficiency, ensuring the sustainability of water resources in Greece.The present study examined potential effect modifiers between polycyclic aromatic hydrocarbon (PAH) exposure and the development of rheumatoid arthritis (RA) and elucidated the relationship between PAHs and RA in subgroups using data from the National Health and Nutrition Examination Survey (NHANES) (2003-2014). The relatedness between eight PAH metabolites and RA in the whole population and different subgroups was tested using multivariable logistic regression analyses. This study included 6297 participants, including 400 RA patients and 5897 non-RA control participants, with full data. Compared to the lowest quartiles, risk of RA was increased in population with the highest quartiles of 1-hydroxynaphthalene (1-NAP), 2-NAP, 2-hydroxyfluorene (2-FLU), and 3-FLU in a bias factor corrected model. The associations between urinary PAH metabolites and RA were prominent in female, young and middle-aged, obese, smoking and alcohol-consuming populations in the subgroup analysis. Our results demonstrated that PAH exposure was related to RA, and the relationship between urinary PAH metabolites and RA differed between subgroups and depended on specific PAH metabolites.Forecasting of climate change impacts on marine aquaculture production has become a major research task, which requires taking into account the biases and uncertainties arising from ocean climate models in coastal areas, as well as considering culture management strategies. Focusing on the suspended mussel culture in the NW Iberian coastal upwelling system, we simulated current and future mussel growth by means of a multistructural net production Dynamic Energy Budget (DEB) model. We considered two scenarios and three ocean climate models to account for climate uncertainty, and applied a bias correction to the climate models in coastal areas. [https://www.selleckchem.com/products/cetuximab.html Cetuximab research buy] Our results show that the predicted impact of climate change on mussel growth is low compared with the role of the seeding time. However, the response of mussels varied across climate models, ranging from a minor growth decline to a moderate growth increase. Therefore, this work confirms that an accurate forecasting of climate change impacts on shellfish aquaculture should take into account the variability linked to both management strategies and climate uncertainty.The long-term anthropogenic release of mercury (Hg) into the environment has led to contamination of the biosphere, with all forms of Hg showing toxic effects and the ability to accumulate in organisms. Since the 1970s, efforts have been made in Western Europe to reduce Hg emissions and for the economic use of Hg, leading to a reduction in Hg exposure to humans and entire ecosystems. The purpose of this research was to present the total mercury (THg) burden in three mustelids (the piscivorous Eurasian otter and American mink, and the invertebrativorous European badger) inhabiting north-western Poland (mostly floodplains) and other European countries (literature data). Moreover, we wanted to investigate whether reductions in the environmental Hg burden in Europe have resulted in reductions in liver and kidney levels in wild terrestrial mammals (Eurasian otter, wild boar, red deer, roe deer, cervids, leporids, rodents, and ecotrophic groups piscivorous mustelids, non-mustelids whose diets include aquatic prey, canids and other carnivores, omnivores, herbivores), between samples collected before and after 2000. We revealed significantly higher nephric THg levels in roadkilled than in trapped American minks. As roadkilled piscivorous mustelids from the same floodplain had similar hepatic and nephric THg concentrations, we suggest that the European research on Hg ecotoxicology should more often use alien American mink instead of the protected Eurasian otter. Badgers inhabiting Polish and other European floodplains bioaccumulated higher amounts of THg than those from other areas, and as such, may be recommended as bioindicator of mercury soil contamination. Our analysis of abundant data on mammalian hepatic and nephric THg concentrations (excluding non-piscivores mustelids) showed that in 12 of 21 cases, Hg concentrations had dropped significantly since 2000. This data signals a reduction in Hg contamination in terrestrial mammals, such as the Eurasian otter, and may be reason for cautious optimism.Hormesis is a biphasic dose-response relationship featured by low-dose stimulation and high-dose inhibition. Although the hormetic phenomenon has been extensively studied over the past decades, there is little information regarding the influence of energy source on the occurrence of hormesis, especially the time-dependent one. In this study, to explore the role of cultivation system's energy source in time-dependent hormesis, the toxic dose-responses of Aliivibrio fischeri (A. fischeri) bioluminescence to Sulfadoxine (SDX) during 24 h were determined in four cultivation systems with different energy source conditions. The results indicated that the time-dependent hormetic effects were induced by SDX in all cultivation systems SDX triggered hormetic phenomenon on the bioluminescence at each growth stage over 24 h in the cultivation systems with sufficient and insufficient energy source; due to the diauxic growth of A. fischeri under multiple energy source conditions, the hormetic effects of SDX gradually disappeared after the preferred energy source was used up. It was speculated that the inhibitory action of SDX was derived from its interaction with DHPS to impede the synthesis of proteins, and SDX bound with AC to upregulate the quorum sensing (QS) system to exhibit the stimulatory action. Comparing the time-dependent hormesis in each cultivation system, it was obtained that the energy source could impact the hourly maximum stimulatory rate, the EC50 of SDX, and the time point that hormesis occurred, which might result from the influence of energy source on the stimulatory and inhibitory actions of SDX through regulating the metabolic system (individual level) and QS system (group level) of bacteria. This study clarifies the importance of energy source for hormesis occurrence, which may further promote the development of hormesis.

Latest revision as of 22:03, 21 October 2024

This paper, based on different sources of information and an extensive database of water related data, collects, evaluates and groups data from a quantity and quality point of view for all the different water bodies of Greece. Specific water districts such as the Aegean islands, the eastern part of Crete, Attica and Thessaly are expected to be the most affected by climate-water impacts with reduced crops yields, a greater risk of droughts and/or floods, a loss of agricultural land, declining water availability, and degraded water resources (surface and groundwater). Based on these findings, the proposed review highlights agricultural adaptation practices for increasing water use efficiency, ensuring the sustainability of water resources in Greece.The present study examined potential effect modifiers between polycyclic aromatic hydrocarbon (PAH) exposure and the development of rheumatoid arthritis (RA) and elucidated the relationship between PAHs and RA in subgroups using data from the National Health and Nutrition Examination Survey (NHANES) (2003-2014). The relatedness between eight PAH metabolites and RA in the whole population and different subgroups was tested using multivariable logistic regression analyses. This study included 6297 participants, including 400 RA patients and 5897 non-RA control participants, with full data. Compared to the lowest quartiles, risk of RA was increased in population with the highest quartiles of 1-hydroxynaphthalene (1-NAP), 2-NAP, 2-hydroxyfluorene (2-FLU), and 3-FLU in a bias factor corrected model. The associations between urinary PAH metabolites and RA were prominent in female, young and middle-aged, obese, smoking and alcohol-consuming populations in the subgroup analysis. Our results demonstrated that PAH exposure was related to RA, and the relationship between urinary PAH metabolites and RA differed between subgroups and depended on specific PAH metabolites.Forecasting of climate change impacts on marine aquaculture production has become a major research task, which requires taking into account the biases and uncertainties arising from ocean climate models in coastal areas, as well as considering culture management strategies. Focusing on the suspended mussel culture in the NW Iberian coastal upwelling system, we simulated current and future mussel growth by means of a multistructural net production Dynamic Energy Budget (DEB) model. We considered two scenarios and three ocean climate models to account for climate uncertainty, and applied a bias correction to the climate models in coastal areas. Cetuximab research buy Our results show that the predicted impact of climate change on mussel growth is low compared with the role of the seeding time. However, the response of mussels varied across climate models, ranging from a minor growth decline to a moderate growth increase. Therefore, this work confirms that an accurate forecasting of climate change impacts on shellfish aquaculture should take into account the variability linked to both management strategies and climate uncertainty.The long-term anthropogenic release of mercury (Hg) into the environment has led to contamination of the biosphere, with all forms of Hg showing toxic effects and the ability to accumulate in organisms. Since the 1970s, efforts have been made in Western Europe to reduce Hg emissions and for the economic use of Hg, leading to a reduction in Hg exposure to humans and entire ecosystems. The purpose of this research was to present the total mercury (THg) burden in three mustelids (the piscivorous Eurasian otter and American mink, and the invertebrativorous European badger) inhabiting north-western Poland (mostly floodplains) and other European countries (literature data). Moreover, we wanted to investigate whether reductions in the environmental Hg burden in Europe have resulted in reductions in liver and kidney levels in wild terrestrial mammals (Eurasian otter, wild boar, red deer, roe deer, cervids, leporids, rodents, and ecotrophic groups piscivorous mustelids, non-mustelids whose diets include aquatic prey, canids and other carnivores, omnivores, herbivores), between samples collected before and after 2000. We revealed significantly higher nephric THg levels in roadkilled than in trapped American minks. As roadkilled piscivorous mustelids from the same floodplain had similar hepatic and nephric THg concentrations, we suggest that the European research on Hg ecotoxicology should more often use alien American mink instead of the protected Eurasian otter. Badgers inhabiting Polish and other European floodplains bioaccumulated higher amounts of THg than those from other areas, and as such, may be recommended as bioindicator of mercury soil contamination. Our analysis of abundant data on mammalian hepatic and nephric THg concentrations (excluding non-piscivores mustelids) showed that in 12 of 21 cases, Hg concentrations had dropped significantly since 2000. This data signals a reduction in Hg contamination in terrestrial mammals, such as the Eurasian otter, and may be reason for cautious optimism.Hormesis is a biphasic dose-response relationship featured by low-dose stimulation and high-dose inhibition. Although the hormetic phenomenon has been extensively studied over the past decades, there is little information regarding the influence of energy source on the occurrence of hormesis, especially the time-dependent one. In this study, to explore the role of cultivation system's energy source in time-dependent hormesis, the toxic dose-responses of Aliivibrio fischeri (A. fischeri) bioluminescence to Sulfadoxine (SDX) during 24 h were determined in four cultivation systems with different energy source conditions. The results indicated that the time-dependent hormetic effects were induced by SDX in all cultivation systems SDX triggered hormetic phenomenon on the bioluminescence at each growth stage over 24 h in the cultivation systems with sufficient and insufficient energy source; due to the diauxic growth of A. fischeri under multiple energy source conditions, the hormetic effects of SDX gradually disappeared after the preferred energy source was used up. It was speculated that the inhibitory action of SDX was derived from its interaction with DHPS to impede the synthesis of proteins, and SDX bound with AC to upregulate the quorum sensing (QS) system to exhibit the stimulatory action. Comparing the time-dependent hormesis in each cultivation system, it was obtained that the energy source could impact the hourly maximum stimulatory rate, the EC50 of SDX, and the time point that hormesis occurred, which might result from the influence of energy source on the stimulatory and inhibitory actions of SDX through regulating the metabolic system (individual level) and QS system (group level) of bacteria. This study clarifies the importance of energy source for hormesis occurrence, which may further promote the development of hormesis.