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The introduction of photodynamic therapy (PDT) in various branches of the dental field such as endodontics, implantology, periodontology, and restorative dentistry and oral medicine has become useful in recent decades. This systematic review presents an overview of the literature to evaluate the usefulness of topical PDT for the treatment of benign oral soft tissue lesions and to identify limitations in prior studies to improve PDT applications.
We performed a review of the literature using different search engines (PubMed, ISI Web of Science, and the Cochrane Library) employing MeSH terms such as "Photodynamic therapy" and "PDT" in conjunction with other terms. We utilized the Population, Intervention, Comparison, Outcomes, and Study design (PICOS) method to define our study eligibility criteria.
Initial results were 1513. Finally, there were only 21 studies that met our selection criteria. We divided the 21 selected items into two groups inflammatory diseases and infective diseases.
Although topical PDT is an easy to perform and well-tolerated treatment and appears to be a valid method with promising results in the treatment of benign lesions of the oral cavity's soft tissues, further studies are needed to complete the current knowledge of this technique.
Although topical PDT is an easy to perform and well-tolerated treatment and appears to be a valid method with promising results in the treatment of benign lesions of the oral cavity's soft tissues, further studies are needed to complete the current knowledge of this technique.
The apparent propagator anisotropy (APA) is a new diffusion MRI metric that, while drawing on the benefits of the ensemble averaged propagator anisotropy (PA) compared to the fractional anisotropy (FA), can be estimated from single-shell data.
Computation of the full PA requires acquisition of large datasets with many diffusion directions and different b-values, and results in extremely long processing times. This has hindered adoption of the PA by the community, despite evidence that it provides meaningful information beyond the FA. Calculation of the complete propagator can be avoided under the hypothesis that a similar sensitivity/specificity may be achieved from apparent measurements at a given shell. Assuming that diffusion anisotropy (DiA) is nondependent on the b-value, a closed-form expression using information from one single shell (ie, b-value) is reported.
Publicly available databases with healthy and diseased subjects are used to compare the APA against other anisotropy measures. The structural information provided by the APA correlates with that provided by the PA for healthy subjects, while it also reveals statistically relevant differences in white matter regions for two pathologies, with a higher reliability than the FA. Additionally, APA has a computational complexity similar to the FA, with processing-times several orders of magnitude below the PA.
The APA can extract more relevant white matter information than the FA, without any additional demands on data acquisition. This makes APA an attractive option for adoption into existing diffusion MRI analysis pipelines.
The APA can extract more relevant white matter information than the FA, without any additional demands on data acquisition. This makes APA an attractive option for adoption into existing diffusion MRI analysis pipelines.
The Theory of Heat Stress Management addresses the phenomenon of occupational heat stress and applies the theory to surgical staff wearing personal protective equipment while performing surgery. This discussion paper relates development of the prescriptive middle range theory of heat stress management to inform and advance research and provide evidence to support new standards of care in clinical nursing practice.
The prescriptive middle range theory was developed by summarizing essential elements of the theory, describing the linkages among the dimensions of the theory, enumerating nursing interventions and physiological, psychological and cognitive outcomes, stating relevant assumptions, defining and identifying relationships between the concepts of heat stress management in observable and measurable terms.
This discussion paper is based on the first author's experiences with occupational heat stress, observed improvements in surgical personnel's thermal comfort by using a cooling intervention and knoactice, education, and research related to heat stress management.
The predictive middle-range Theory of Heat Stress Management will guide nurses to promote the health and well-being of healthcare workers and influence and improve clinical nursing practice, education, and research related to heat stress management.Food contamination and food poisoning pose enormous risks to consumers across the world. As discussions of consumer experiences have spread through online media, we propose the use of text mining to rapidly screen online media for mentions of food safety hazards. We compile a large data set of labeled consumer posts spanning two major websites. this website Utilizing text mining and supervised machine learning, we identify unique words and phrases in online posts that identify consumers' interactions with hazardous food products. We compare our methods to traditional sentiment-based text mining. We assess performance in a high-volume setting, utilizing a data set of over 4 million online reviews. Our methods were 77-90% accurate in top-ranking reviews, while sentiment analysis was just 11-26% accurate. Moreover, we aggregate review-level results to make product-level risk assessments. A panel of 21 food safety experts assessed our model's hazard-flagged products to exhibit substantially higher risk than baseline products. We suggest the use of these tools to profile food items and assess risk, building a postmarket decision support system to identify hazardous food products. Our research contributes to the literature and practice by providing practical and inexpensive means for rapidly monitoring food safety in real time.
RP3128, a novel, orally available modulator of calcium released activated calcium (CRAC) channel, is being developed for the potential treatment of autoimmune and inflammatory diseases. RP3128 showed nano-molar potency and activity in a range of in vitro and in vivo models of inflammation. We report a first-in-human study investigating the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of RP3128 in healthy subjects.
A randomized, double-blind, placebo-controlled trial of single (25, 50, 100, 200 and 400mg) and multiple (7days 25, 100 and 400mg once daily) doses of RP3128 were performed. Thirty-two and 24 subjects were randomized in the single ascending dose (SAD) and multiple ascending dose (MAD) parts, respectively.
RP3128 was well tolerated, with no dose-limiting toxicity at single and multiple doses. Incidence of treatment emergent adverse events (TEAEs) did not increase with ascending RP3128 doses. No changes were seen in cognitive function and ECG parameters. RP3128 was rapidly absorbed.