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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often focused on the practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of commonly available equipment.
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프라그마틱 불법 that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can cause problems with the design of the trial.
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The goal of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are usually ordered by policymakers and practitioners to help inform their decisions. They can also be used to determine the causality of an intervention and its effects. However, they should not be used to replace explanation studies.
The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a pragmatic study, including the recruitment process, the design and implementation of the intervention, as well as follow-up.
There is a growing increase in the number of pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatics. It is important to remember that the majority of these trials were conducted in primary care settings.