Cucatalyzed Dsp2Nbond direction involving boronic fatty acids and also cyclic imides

This text tells the story of the launching, development, and current status of the scientific Journal Ciência & Saúde Coletiva from the perspective of who was responsible for its creation, and aims to contribute to the construction of the memory of a national journal, its possibilities, and limitations. While it is a personal statement, the theoretical perspective of narrative is employed in its elaboration, which consists of the use of a singular sequence of events, mental states, events involving human beings as characters or authors, which can be real or imaginary without losing its power as history. Authors who work with studies of narratives and scientific construction processes are reference, and the context in which the story takes place is explained. The study shows the importance of having clear goals, persistent work, and interconnection of important social actors, institutional support, and national and international cooperation in the Journal's management. The role of individuals and organizations is highlighted. The paper concludes that the Journal endorses intellectual production, ensures intellectual property, legitimizes new themes, and defines the limits of what is publishable in Collective Health, in line with its primary principles.The presence of acidic compounds as naphthenic acids in crude oil causes several problems for the petroleum industry, including corrosion in both upstream and downstream production processes. Based on this scenario, the main objective of this work was to investigate the removal of the acidic compound from two Brazilian heavy oils by adsorption processes using six potential adsorbents powdered shale, activated carbon, bentonite, silica gel, powdered sandstone and powdered wood. These raw materials were previously characterized by conventional and surface analysis techniques, which show that they offer a good surface area and thermal stability. To evaluate the removal efficiency at the molecular level, the crude oil samples and the filtered oils were analyzed by negative electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry [ESI (-) FTICR MS]. selleck kinase inhibitor The O2 class, which is related to the relatively high acidity of the samples, was the most abundant in both crude oil samples, moreover, this class was more retained by adsorbents. Silica gel, activated carbon and bentonite were the best adsorbents of acidic compounds from the tested oils, in agreement with their markedly higher surface area and porous volume. Additionally, a chromatographic analysis was performed and showed no changes in the oil profile.Biomass of Saccharomyces cerevisiae wasenhancedin rice polishing by fermentation to increase protein contents of feedfor its use in livestock. Broth culture of Saccharomyces cerevisiae (2.6×108CFU/mL) was prepared from culture obtained by continuous streaking. The isolated culture was identified morphologically by Gram staining and confirmed by biochemical characteristics. Rice polishing was sieved to remove larger particles. Then it was distributed to 4 treatments in triplicates. Treatments were represented as rice polishing (RP), rice polishing plus Saccharomyces culture (RPSC), rice polishing plus ammonium sulphate (RPAS), rice polishing plus Saccharomyces culture plus ammonium sulphate (RPSCAS).Fermentation was provided for 144 hours at 320C,while samples were collected after every 24 hours. Samples were dried, ground and subjected to proximate analysis. It was observed that protein content was increased from 11% to 21.51% and maximum increment was obtained after 144 hours of incubation in RPSC treatment. Ether extract and ash were increased from 14% and 10% to 16.96% and 11.11% in RPSCAS respectively. A significant reduction in neutral detergent fiber was observed after fermentation. It is concluded that Saccharomyces cerevisiae has potential to improve mineral and protein contents of rice polishing by fermentation process with or without addition of nitrogen source.Systems integration is critical to the engineering of successful complex products and systems. The Technology Readiness Levels (TRL) scale assists in making decisions about the infusion of new technologies into complex systems. This scale presents challenges to represent the integration between technologies in a system. The Integration Readiness Levels (IRL) scale aims to address these challenges. A good practice for objective technology readiness assessments is to rely on evidence-based documentation. link2 The TRL scale shows the evidence required for each level of the scale and the appropriate types of documents to collect this evidence, while the IRL scale proposes only the necessary evidence for each level. This research proposes a set of information items to document the required evidence for each level of the IRL scale. The results show the main stages of investigation and the successful tests of the proposal in a case study with spacecraft developed in the binational program China-Brazil Earth Resources Satellite (CBERS). This article contributes to the research in integration readiness assessments, aims to support professionals who carry out evidence-based evaluations and, consequently, may contribute to improving the accuracy of decision-making in the systems integration by using this scale.Human populations maintain diverse relationships with wild animals that lead to both positive and negative interactions. The aim of the present study was to investigate the ecology, interactions and human perceptions of Cerdocyon thous in rural landscapes in the state of Pernambuco in northeastern Brazil. Interviews were held from November to December 2015. Data collection involved the use of a semi-structured questionnaire and photographs of the fox. Most interviewees (96.94%) demonstrated knowledge of the species, attributing eight different vernacular denominations to the animal. link3 The interviewees also demonstrated knowledge regarding its habitats, active hours, diet, behavior and diseases. The respondents pointed out negative aspects, such as the transmission of diseases (48.72%), the death of domesticated animals and consequent negative economic impact (42.74%), attacks against humans and other animals (6.84%) and causing an environment imbalance (1.70%). The positive roles attributed to the fox regarded its use as a resource for medicinal purposes, craftwork, mystical-religious ceremonies and as a pet. There is a need for further information on C. thous and adequate protection measures should be taken in local communities to ensure the conservation of the species in rural landscapes.Abietane diterpenoids are naturally occurring plant metabolites with a broad spectrum of biological effects including antibacterial, antileishmanial, antitumor, antioxidant, as well as antiinflammatory activities. Recently, we found that some analogues of natural ferruginol ( 2 ) actively inhibited dengue virus 2 (DENV-2) replication. Due to the similarity with DENV, we envisaged that abietane diterpenoids would also be active against Zika virus (ZIKV). Six selected semi-synthetic abietane derivatives of (+)-dehydroabietylamine ( 3 ) were tested. Cytotoxicity was determined by MTT assay in Vero cells. In vitro anti-ZIKV (clinical isolate, IMT17) activity was evaluated by plaque assay. Interestingly, these molecules showed potential as anti-ZIKV agents, with EC50 values ranging from 0.67 to 18.57 µM, and cytotoxicity (CC50 values) from 2.56 to 35.09 µM. The 18-Oxoferruginol (8) (EC50 = 2.60 µM, SI = 13.51) and 12-nitro-N-benzoyldehydroabietylamine (9) (EC50= 0.67 µM, SI = 3.82) were the most active compounds, followed by 12-hydroxy-N-tosyldehydroabietylamine ( 7 ) (EC50 = 3.58 µM, SI = 3.20) and 12-hydroxy-N,N-phthaloyldehydroabietylamine ( 5 ) (EC50 = 7.76 µM, SI = 1.23). To the best of our knowledge, this is the first report on anti-Zika virus properties of abietanes.Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen in the last decade. Increased resistance to sulfamethoxazole/trimethoprim (SMX/TMP) has been reported in S. maltophilia strains in the past few years, leading to few therapeutic options. We conducted a prospective multicenter study at two Brazilian teaching hospitals that identified S. maltophilia isolates and evaluated their antimicrobial susceptibility profile, SMX/TMP resistance genes and their clonality profile. A total of 106 non-repeated clinical samples of S. maltophilia were evaluated. Resistance to SMX/TMP was identified in 21.6% of the samples, and previous use of SMX/TMP occurred in 19 (82.6%). PCR detected the sul1 gene in 14 of 106 strains (13.2%). Of these isolates, nine displayed resistance to SMX/TMP. The resistant strains presented a polyclonal profile. This opportunistic pathogen has emerged in immunocompromised hosts, with few therapeutic options, which is aggravated by the description of emerging resistance mechanisms, although with a polyclonal distribution profile.
to construct and validate an educational gerontechnology on frailty in elderly people.
a methodological study developed in three stages educational video construction, validation by expert judges and elderly people. Validation was carried out by 22 judges and 22 elderly people. Educational Content Validation Instrument was used for judges and questions adapted from the Suitability Assessment of Materials questionnaire for elderly people. For validation, agreement criterion greater than 80% was considered, verified using Content Validation Index and binomial test.
the video addresses recommendations for elderly people at risk of frailty and health-promoting habits, using cordel literature. An agreement greater than 80% was verified in all items assessed by judges and the target audience.
the video proved to be valid in terms of content and appearance by judges and elderly people, with the potential to mediate health-promoting educational practices in healthy aging.
the video proved to be valid in terms of content and appearance by judges and elderly people, with the potential to mediate health-promoting educational practices in healthy aging.
To understand the management of home care by family caregivers of dependent elderly people after hospital discharge.
Qualitative research guided by hermeneutics-dialectic, anchored in the theory of communicative action. Data collection took place using a semi-structured interview with 11 participants.
Two categories were constructed Management of the many types of care by the caregiver and the relationship between family caregiver and health care network. Care and management actions carried out routinely cause major changes in the family caregiver's life. He/she does not recognize planning, home care periodicity or support in required procedures.
The management of home care for dependent elderly people after hospital discharge is complex, involving physical and emotional overloads, as well as difficulties in getting support from health services. The planning shared between the health team and the family since the discharge is required, and the better visibility of the role of primary care when the patient is assisted by a home care service.
The management of home care for dependent elderly people after hospital discharge is complex, involving physical and emotional overloads, as well as difficulties in getting support from health services. The planning shared between the health team and the family since the discharge is required, and the better visibility of the role of primary care when the patient is assisted by a home care service.