Cyclodextrin Polymers while Shipping and delivery Programs pertaining to Precise AntiCancer Chemotherapy

In this work, we develop a unified lattice Boltzmann model (ULBM) framework that can seamlessly integrate the widely used lattice Boltzmann collision operators, including the Bhatnagar-Gross-Krook or single-relation-time, multiple-relaxation-time, central-moment or cascaded lattice Boltzmann method and multiple entropic operators (KBC). Such a framework clarifies the relations among the existing collision operators and greatly facilitates model comparison and development as well as coding. Importantly, any LB model or treatment constructed for a specific collision operator could be easily adopted by other operators. We demonstrate the flexibility and power of the ULBM framework through three multiphase flow problems the rheology of an emulsion, splashing of a droplet on a liquid film and dynamics of pool boiling. Further exploration of ULBM for a wide variety of phenomena would be both realistic and beneficial, making the LBM more accessible to non-specialists. This article is part of the theme issue 'Progress in mesoscale methods for fluid dynamics simulation'.A model based on the Lattice Boltzmann method is developed to study the flow of reactive electro-kinetic fluids in porous media. The momentum, concentration and electric/potential fields are simulated via the Navier-Stokes, advection-diffusion/Nernst-Planck and Poisson equations, respectively. With this model, the total density and velocity fields, the concentration of reactants and reaction products, including neutral and ionized species, the electric potential and the interaction forces between the fields can be studied, and thus we provide an insight into the interplay between chemistry, flow and the geometry of the porous medium. The results show that the conversion efficiency of the reaction can be strongly influenced by the fluid velocity, reactant concentration and by porosity of the porous medium. The fluid velocity determines how long the reactants stay in the reaction areas, the reactant concentration controls the amount of the reaction material and with different dielectric constant, the porous medium can distort the electric field differently. All these factors make the reaction conversion efficiency display a non-trivial and non-monotonic behaviour as a function of the flow and reaction parameters. To better illustrate the dependence of the reaction conversion efficiency on the control parameters, based on the input from a number of numerical investigations, we developed a phenomenological model of the reactor. This model is capable of capturing the main features of the causal relationship between the performance of the reactor and the main test parameters. Using this model, one could optimize the choice of reaction and flow parameters in order to improve the performance of the reactor and achieve higher production rates. T-5224 research buy This article is part of the theme issue 'Progress in mesoscale methods for fluid dynamics simulation'.The ordering of particles in the drying process of a colloidal suspension is crucial in determining the properties of the resulting film. For example, microscopic inhomogeneities can lead to the formation of cracks and defects that can deteriorate the quality of the film considerably. This type of problem is inherently multiscale and here we study it numerically, using our recently developed method for the simulation of soft polymeric capsules in multicomponent fluids. We focus on the effect of the particle softness on the film microstructure during the drying phase and how it relates to the formation of defects. We quantify the order of the particles by measuring both the Voronoi entropy and the isotropic order parameter. Surprisingly, both observables exhibit a non-monotonic behaviour when the softness of the particles is increased. We further investigate the correlation between the interparticle interaction and the change in the microstructure during the evaporation phase. We observe that the rigid particles form chain-like structures that tend to scatter into small clusters when the particle softness is increased. This article is part of the theme issue 'Progress in mesoscale methods for fluid dynamics simulation'.Activity in nematics drives interfacial flows that lead to preferential alignment that is tangential or planar for extensile systems (pushers) and perpendicular or homeotropic for contractile ones (pullers). This alignment is known as active anchoring and has been reported for a number of systems and described using active nematic hydrodynamic theories. The latter are based on the one-elastic constant approximation, i.e. they assume elastic isotropy of the underlying passive nematic. Real nematics, however, have different elastic constants, which lead to interfacial anchoring. In this paper, we consider elastic anisotropy in multiphase and multicomponent hydrodynamic models of active nematics and investigate the competition between the interfacial alignment driven by the elastic anisotropy of the passive nematic and the active anchoring. We start by considering systems with translational invariance to analyse the alignment at flat interfaces and, then, consider two-dimensional systems and active nematic droplets. We investigate the competition of the two types of anchoring over a wide range of the other parameters that characterize the system. The results of the simulations reveal that the active anchoring dominates except at very low activities, when the interfaces are static. In addition, we found that the elastic anisotropy does not affect the dynamics but changes the active length that becomes anisotropic. This article is part of the theme issue 'Progress in mesoscale methods for fluid dynamics simulation'.The tumbling to tank-treading (TB-TT) transition for red blood cells (RBCs) has been widely investigated, with a main focus on the effects of the viscosity ratio [Formula see text] (i.e., the ratio between the viscosities of the fluids inside and outside the membrane) and the shear rate [Formula see text] applied to the RBC. However, the membrane viscosity [Formula see text] plays a major role in a realistic description of RBC dynamics, and only a few works have systematically focused on its effects on the TB-TT transition. In this work, we provide a parametric investigation on the effect of membrane viscosity [Formula see text] on the TB-TT transition for a single RBC. It is found that, at fixed viscosity ratios [Formula see text], larger values of [Formula see text] lead to an increased range of values of capillary number at which the TB-TT transition occurs; moreover, we found that increasing [Formula see text] or increasing [Formula see text] results in a qualitatively but not quantitatively similar behaviour. All results are obtained by means of mesoscale numerical simulations based on the lattice Boltzmann models. This article is part of the theme issue 'Progress in mesoscale methods for fluid dynamics simulation'.Ionic polymer-metal composites (IPMCs) constitute a promising class of soft, active materials with potentially ubiquitous use in science and engineering. Realizing the full potential of IPMCs calls for a deeper understanding of the mechanisms underpinning their most intriguing characteristics the ability to deform under an electric field and the generation of a voltage upon mechanical deformation. These behaviours are tightly linked to physical phenomena at the level of atoms, including rearrangements of ions and molecules, along with the formation of sub-nanometre thick double layers on the surface of the metal electrodes. Several continuum theories have been developed to describe these phenomena, but their experimental and theoretical validation remains incomplete. IPMC modelling at the atomistic scale could beget valuable support for these efforts, by affording granular analysis of individual atoms. Here, we present a simplified atomistic model of IPMCs based on classical molecular dynamics. The three-dimensional IPMC membrane is constrained by two smooth walls, a simplified analogue of metal electrodes, impermeable only to counterions. The electric field is applied as an additional force acting on all the atoms. We demonstrate the feasibility of simulating counterions' migration and pile-up upon the application of an electric field, similar to experimental observations. By analysing the spatial configuration of atoms and stress distribution, we identify two mechanisms for stress generation. The presented model offers new insight into the physical underpinnings of actuation and sensing in IPMCs. This article is part of the theme issue 'Progress in mesoscale methods for fluid dynamics simulation'.
While the Edinburgh Postnatal Depression Scale (EPDS) is a standard clinical screening tool for postpartum depression, it is unclear whether it is culturally appropriate for Chinese immigrant women in the United States. Cognitive interviewing (CI) is a method for evaluating a scale's cultural appropriateness. However, CI procedures are problematic with Chinese population. This study assesses three culturally tailored strategies for implementing CI to evaluate the Chinese version of the EPDS (C-EPDS).
CI was conducted with 12 participants in the United States. Three culturally tailored strategies-a CI description, a vignette exercise, and debriefing were used. Directed content analysis was used for data analysis.
The strategies increased participants' understanding and ability to perform CI procedures, enabling them to discuss postpartum depression. Participants had difficulty responding to several C-EPDS items.
Findings highlight the importance of using culturally tailored strategies for implementing CI to assess cultural appropriateness of clinical screening tools.
Findings highlight the importance of using culturally tailored strategies for implementing CI to assess cultural appropriateness of clinical screening tools.
COVID-19 has caused great changes in all aspects of life which affected all people especially vulnerable groups such as children with disabilities (CWD) and their families.
This study aimed to examine the challenges facing caregivers of CWD during the pandemic, and to explore these challenges from various physical, social, psychological, and financial aspects.
A cross-sectional design was conducted in Palestine, a total of 130 caregivers of CWD completed a survey consisting of demographic and clinical characteristics questionnaire and the short version of the burden scale for family caregivers (BSFC-s) between March and May 2021.
Most of the caregivers were mothers (76.9%), the mean age of the children was (6.09 ± 3.43 years). The majority (88.5%) of the caregivers felt physically exhausted, about (75.4%) had decreased living standards, and (86.2%) indicated that caregiving is taking their strength. A high burden score was recorded, the mean BSFC-s score was 20.17 ± 5.57. Significant differences in BSFC-s scores were recorded based on the type of disability, and child's ability to take care of oneself,
 < .05. The total scores of the BSFC-s were positively correlated with the physical, social, psychological, and financial challenges facing the caregivers (
 < .001).
COVID-19 has caused increased burdens on the caregivers of CWD and a negative impact on the child's mobility accompanying a lack of access to health and rehabilitation services. Vital factors are to be considered in developing strategic health and rehabilitative plans for promoting better care for caregivers and their CWD during lockdown restrictions time.
COVID-19 has caused increased burdens on the caregivers of CWD and a negative impact on the child's mobility accompanying a lack of access to health and rehabilitation services. Vital factors are to be considered in developing strategic health and rehabilitative plans for promoting better care for caregivers and their CWD during lockdown restrictions time.