Different functions of FOXO family members in stomach cancer malignancy

Ozonation has been widely applied for the oxidation of contaminants in wastewater, and the disinfection of water. However, low ozone (O3) mass transfer efficiency in common ozonation reactors requires high O3 doses and causes high energy consumption. In this study, to intensify the O3 mass transfer and oxidation of humic acids (HA) solution, a lava rock packed bubble column (LBC) and a metal pall ring packed bubble column (MBC) were developed and evaluated. In comparison with non-packed bubble column (BC), both LBC and MBC enhanced the O3 mass transfer efficiency and the generation of hydroxyl radicals, thereby increasing the HA removal from an aqueous solution. At applied O3 dose of 33.3 mg/(Lcolumn h), the HA removal efficiency in BC was only 47%. When MBC and LBC were applied, it increased to 66% and 72%, respectively. Meanwhile, the O3 utilization efficiency in LBC reached 68%, which was higher than that in MBC (50%) and BC (21%). Consequently, LBC has the lowest energy consumption (EEO) for HA removal (1.4 kWh/m3), followed by MBC (1.6 kWh/m3) and BC (2.9 kWh/m3). LBC had better performance than MBC due to the adsorptive and catalytic roles of lava rock on the ozonation process. This study demonstrates the advantages of using lava rocks as packed materials in O3 bubble column over metal pall rings in intensifying O3 mass transfer and organic matters removal, which provides some insights into promoting the industrial application of O3.The Fenton process activated by Zero Valent Iron (ZVI-Fenton) is shown here to effectively remove antibiotics reserved for hospital settings (specifically used to treat antibiotic-resistant infections) from wastewater, thereby helping in the fight against bacterial resistance. Effective degradation of cefazolin, imipenem and vancomycin in real urban wastewater was achieved at pH 5, which is quite near neutrality when compared with classic Fenton that works effectively at pH 3-4. The possibility to operate successfully at pH 5 has several advantages compared to operation at lower pH values (i) lower reagent costs for pH adjustment; (ii) insignificant impact on wastewater conductivity, because lesser acid is required to acidify and lesser or no base for neutralization; (iii) undetectable release of dissolved Fe, which could otherwise be an issue for wastewater quality. The cost of reagents for the treatment ranges between 0.04 and 0.07 $ m-3, which looks very suitable for practical applications. The structures of the degradation intermediates of the studied antibiotics and their likely abundance suggest that, once the primary compound is eliminated, most of the potential to trigger antibiotic action has been removed. Application of the ZVI-Fenton technique to wastewater treatment could considerably lower the possibility for antibiotics to trigger the development of resistance in bacteria.Synergistic effect of zinc oxide nanoparticles (ZnO-NPs) as photocatalyst and organonanoclay (ONC) as biodegradable promoter on the degradation of polystyrene (PS) film was investigated. The films were exposed to ultraviolet irradiation under ambient air at room temperature for photo-catalytic degradation and then submitted to biodegradation test in soil using respirometric procedure. Fourier-transform infrared and ultraviolet-visible spectroscopy, thermogravimetric analysis, colorimeter technique, contact angle measurement, and the carbon dioxide evolution results showed higher photo- and biodegradation efficiency of PS-ONC-ZnO nanocomposite compared to the neat PS, PS-ONC and PS-ZnO nanocomposites. Thermal stability, optical band gap, and water contact angle of photo-degraded PS-ONC-ZnO nanocomposite decreased by 11.37, 18.33 and 63.99%, respectively, while that of PS film was only 6.20, 6.44 and 5.84%, respectively. The photo-degraded PS-ONC-ZnO and PS-ZnO film indicated a biodegradation percentage value of 3.3 and 2.1%, respectively, over 16 weeks of incubation in soil. The possible degradation mechanism of nanocomposites was briefly discussed.To overcome the bottlenecks of waste resource utilization and energy shortage that restrict the commercial production of microalgae biodiesel, volatile fatty acids (VFAs) derived from activated sludge were used as the sole carbon source to culture oleaginous microalgae Chlorella pyrenoidosa FACHB-1216 and Scenedesmus quadricauda FACHB-1297 under the mixotrophic and heterotrophic cultivation. Four VFAs ratios (acetic acids (AA) propionic acids (PA) butyric acids (BA)) were tested to determine the effects and mechanisms of the VFAs on the two microalgae. The highest lipid content (29.54%) and lipid production (71.10 mg L-1) were achieved by S. quadricauda at the VFAs ratio of 6 1 3 under heterotrophic condition, with 46.27% and 67.52% removal efficiencies of total nitrogen and phosphorus, respectively. The assimilation efficiency of AA was the highest at 73.37%, followed by that of PA and BA. For C. pyrenoidosa, VFAs promoted the rapid reproduction within 2 days under the heterotrophic condition at different initial inoculation densities. At the optimal VFA ratio, algae achieved the highest biomass concentration (0.14 ± 0.02 g L-1), with a specific growth rate of 0.91 d-1 and biomass productivity of 125.17 mg L-1 d-1. The removal rates of total nitrogen and phosphorus were 47.03% and 74.40%, respectively, and the assimilation efficiency of AA was the best (61.06%). High AA assimilation efficiency under the heterotrophic condition was beneficial for the algal growth and lipid accumulation. These results simultaneously produced microalgae-based bioenergy and recycled VFAs in anaerobically digested effluent.Omics longitudinal studies are effective experimental designs to inform on the stability and dynamics of microbial communities in response to perturbations, but time-course analytical frameworks are required to fully exploit the temporal information acquired in this context. In this study we investigate the influence of ammonia on the stability of anaerobic digestion (AD) microbiome with a new statistical framework. Ammonia can severely reduce AD performance. Understanding how it affects microbial communities development and the degradation progress is a key operational issue to propose more stable processes. Thirty batch digesters were set-up with different levels of ammonia. Microbial community structure and metabolomic profiles were monitored with 16 S-metabarcoding and GCMS (gas-chromatography-mass-spectrometry). Digesters were first grouped according to similar degradation performances. Within each group, time profiles of OTUs and metabolites were modelled, then clustered into similar time trajectories, evidencing for example a syntrophic interaction between Syntrophomonas and Methanoculleus that was maintained up to 387 mg FAN/L. Metabolites resulting from organic matter fermentation, such as dehydroabietic or phytanic acid, decreased with increasing ammonia levels. Our analytical framework enabled to fully account for time variability and integrate this parameter in data analysis.Production of MCFAs (Medium-chain fatty acids) from simple substrate (i.e., ethanol and acetate) and WAS with chain elongation microbiome was investigated in this study. The results showed that rapid production of MCFAs was observed when simple substrate was utilized. 1889 mg/L of caproate and 3434 mg/L of butyrate were achieved after 10 d's reaction. H2 proportion in the headspace could reach as high as 10.1% on day 8 and then declined quickly. However, when WAS was used, the bacterial consortia was not able to hydrolyze WAS efficiently, which resulted in poor MCFAs production performance. Presence of ethanol could improve the hydrolysis process to a limited degree, which resulted in solubilization of a small fraction of protein and carbohydrate. Around 33.8% and 36.9% of the total detected electrons on day 6 in the 50 mM and 100 mM tests were extracted from WAS respectively. Those results indicate that the chain elongation microbial consortia tended to receive electrons form ethanol directly other than the complex WAS.Herbicides are commonly used globally. However, residual herbicides in soils for ages often result in phytotoxicity and serious yield loss to subsequent crops. In this paper, the multi-walled carbon nanotubes (MWCNTs) were utilized to amend the herbicide polluted soil, and the adsorption performance of herbicides to MWCNTs amended soil was studied. Results indicate efficient alleviation of herbicide-induced phytotoxicity to rice and tobacco due to MWCNTs amendment. When 0.4% MWCNTs were applied, the concentration of sulfentrazone that inhibited the same rice height by 50% (IC50) increased to more than 3 times that of pure soil. When the MWCNTs were used to alleviate the phytotoxicity of quinclorac to tobacco, the MWCNTs not only alleviated the phytotoxicity of quinclorac but also promoted the growth of tobacco. The MWCNTs amended soil significantly increased the adsorption of herbicide to soil than biochar. The soil microbial analysis shows that MWCNTs had no significant effect on soil microbial community diversity, but the long-term exposure to MWCNTs could change the structure of the soil microbial community. Above all, our results highlighted the potential implication of the MWCNTs to ensure crop production by promoting crop growth and reducing the residual bioavailability of herbicides.The COVID-19 pandemic created a global crisis impacting not only healthcare systems, but also economics and society. Therefore, it is important to find novel methods for monitoring disease activity. Recent data have indicated that fecal shedding of SARS-CoV-2 is common, and that viral RNA can be detected in wastewater. This suggests that wastewater monitoring is a potentially efficient tool for both epidemiological surveillance, and early warning for SARS-CoV-2 circulation at the population level. In this study we sampled an urban wastewater infrastructure in the city of Ashkelon (̴ 150,000 population), Israel, during the end of the first COVID-19 wave in May 2020 when the number of infections seemed to be waning. We were able to show varying presence of SARS-CoV-2 RNA in wastewater from several locations in the city during two sampling periods, before the resurgence was clinically apparent. This was expressed with a new index, Normalized Viral Load (NVL) which can be used in different area scales to define levels of virus activity such as red (high) or green (no), and to follow morbidity in the population at the tested area. The rise in viral load between the two sampling periods (one week apart) indicated an increase in morbidity that was evident two weeks to a month later in the population. Thus, this methodology may provide an early indication for SARS-CoV-2 infection outbreak in a population before an outbreak is clinically apparent.The raw water distribution systems (RWDSs) play key roles in urban water supply systems. https://www.selleckchem.com/products/ipi-549.html The changes of disinfection byproducts (DBPs) precursors of trihalomethanes (THMs), haloacetic acids (HAAs) and halogenated acetaldehydes (HALs) in the RWDS in Taihu Basin were investigated by formation potentials. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) method and 454-pyrosequencing were employed to study the variation of molecular characteristics of low molecular weight-dissolved organic matter (LMW-DOM) and microbial communities of pipeline biofilms respectively, which played crucial roles in the variation of DBPs precursors. The results showed that both DBPs precursors and the molecular characteristics of LMW-DOM in the RWDS had changed. Moreover, the LMW-DOM could be an indicator due to the good positive correlation with precursors of HAAs and HALs. Specifically, the LMW-DOM showed continuous accumulation in the RWDS. The LMW-DOM tended to possess higher m/z and more CH2 or long alkyl chains while pre-chlorination controlled this trend.