Genetic makeup Methylation Profiling An Emerging Paradigm pertaining to Cancers Diagnosis

This study describes the clinical experience with the use of Easy Bite® light-curing hydrostatic splint for initiating muscle relaxation and determining the therapeutic position of the lower jaw under the control of surface electromyography at the stage of occlusal splinting prior to orthodontic treatment. Surface electromyography was performed using a BTS TMJOINT apparatus from BTS Bioengineering (Italy) and the Dental Contact Analyzer software package. The article describes the interpretation of the six indices, such as POC TA, POC MM, BAR, TORS, IMP, ASIM, for the analysis of occlusion and muscle balance in a clinical example with illustrations. The developed algorithm for determining the therapeutic position of the lower jaw is described and the results of 5 months of occlusal splint therapy of a 12-year-old patient with skeletal grade 2, a vertical type of jaw growth, a skeletal reduction of the lower jaw branch on the right, aseptic necrosis and fragmentation of the articular head of the right TMJ, arthritis-arthrosis of the left TMJ, dysplasia of both TMJs on the background of undifferentiated connective tissue dysplasia are presented.At present, our country continues intensive research to find and introduce into practice new natural medicinal preparations made from ecologically clean endemic plants of Georgia. An example of such studies in the Iveria-Pharma company is the domestic drug Lazolex (extract of the pericarpium of an unripe walnut), which has passed the necessary preclinical tests and began to be used in the clinic as an antiherpetic agent. On healthy volunteers, we found positive immunotropic effects of Lazolex. Therefore, we considered it necessary to study the antiviral effect of the drug and its immunomodulatory properties in a clinical setting, specifically in chronic herpetic stomatitis. First of all, it was shown that the state of the patients' immune system was in a clear correlation with the severity of the herpes process, i.e. the most severe immunosuppression was recorded in patients with severe stomatitis. The double effect of the drug is to significantly increase the results of antiviral treatment and immunorehabilitation of patients. As a result of a parallel study of Zovirax and Lazolex, a high clinical activity of both drugs was recorded. However, the presence of pronounced immuno-corrective properties in Lazolex manifested itself in an improvement in the quality of patient treatment active tissue regeneration and a significant decrease in the timing of exacerbation of local herpetic lesions, an increase in the duration of remission. Conducted clinical, laboratory and immunological studies allow us to recommend Lazolex for active use in dental practice for viral diseases.Autoaggression as a form of self-harm has many manifestations. Self-harming behavior accompanies a wide range of mental disorders, including schizophrenia. The aim of our study is to inform clinicians, including ophthalmologists and psychiatrists, about their own perforation of the eye in patients with mental disorders based on a clinical case. We present a clinical observation of a young patient with schizophrenia with penetrating damage to the right eye. The studies used specific methods of clinical ophthalmic surgery, consultations with a psychiatrist and a content analysis of professional literature on this issue. The case presented by us indicates that self-harming behavior is a frequent occurrence and indicates the presence of experiences and/or mental disorders that may lead to suicide in the future. Such behavior requires further study, research, as well as the creation of diagnostic techniques and methods of correctional work.The article represents clinical and pathoanatomical analysis of a case of full-term pregnancy with hypoplastic left heart syndrome (HLHS) in one of the twins, which occurred using in vitro fertilization (IVF). The dead macerated fetus with malformations after selective feticide at the 20th week of pregnancy and dichorial diamniotic placenta were studied. In connection with the expressive autolytic changes in the internal organs of the fetus, which do not allow to confirm the diagnosis of left ventricular hypoplasia at autopsy and establish its type of structure, additional measurements of the heart structures of the fetus with HLHS on archived video materials of ultrasound diagnostics were performed. After calculating the diagnostic indices the index of myocardial layer thickness (ratio of the thicknesses of the trabecular and compact myocardium), the index of cavity shape of the heart in frontal axis (ratio of width to cavity length), cavity-myocardial index (ratio of wall thickness to cavity width), the cylindrical LV structure was retrospectively determined, which is prognostically unfavorable any kind of surgical correction, which justified selective feticide. The article presents the values of diagnostic indices for identifying the types of structure of hypoplastic LV. Prenatal determination of LV type determines treatment tactics terminate pregnancy in case of adverse LV types, recommend Norwood procedure in the neonatal period with type I or perform fetal aortic valvuloplasty with type II of LV. The maturation disorders (distal villous hypoplasia) that we found in the placenta of a living fetus confirms that, despite the relatively satisfactory condition of the newborn, pregnancies that occur with the use of IVF are high risk group of developmental disability both the fetus and placenta.The study included 12 patients who underwent extracorporeal nephron-sparing surgery followed by autotransplantation of the kidney to the iliac region. A solitary kidney occurred in 7 (58.3%) cases, bilateral tumors in 2 (16.7%) cases, a significant decrease in the function of the contralateral kidney in 2 (16.7%) cases, and relative imperative indications in 1 (8.3%) patient. The ECOG status 0, 1 and 2, respectively, was recorded in 3 (25%), 6 (50%) and 3 (25%) cases. The glomerular filtration rate in patients (GFR) averaged 51.5±16.8 ml/min, the blood creatinine level was 157.9±58.2 µmol/L, and the body mass index (BMI) was 27.7±4.9 kg/m2. The average size of tumors in the entire group reached 5.6±1.8 cm (3 to 9 cm). Selleckchem Nec-1s T1 stage was registered in 6 cases, T3a was diagnosed in another 6 cases. Besides, invasion into the renal vein was detected in 4 patients, into the pararenal or renal sinus fat in another 4 patients, into the pelvicalyceal system lumen in yet another 4 patients. Intrarenal tumors were found in 11 (91.