Granulomatous interstitial nephritis

We observed significant correlations between perceptual and response inhibition and fluid intelligence (controlling for age), but only perceptual inhibition explains significantly part of the performance in the fluid intelligence task. This study provides data about the specific contribution, during childhood, of an inhibitory type to fluid intelligence and contributes empirical evidence in support of the non-unitary approach of inhibition.Using nation-wide survey data (N=2328) from China, this study investigates how social support from family, peers, and teachers influence low-income household children's (from 13 to 15 years old) academic resilience, as well as how academic resilience mediates the relationship between social support and children's academic achievement. Structural equation modelling was adopted to analyse the data. The results reveal that (1) low-income household children's family, peer, and teacher support are associated with their academic resilience; (2) peer support and academic resilience of low-income household children significantly relate with their academic achievements; (3) academic resilience plays a full mediation role in teacher support and a partial mediation role in peer support on children's academic achievement. The implications of this study on theory and practice, the limitations, and future research directions are discussed.Parental practices such as inconsistent discipline, psychological control, and imposition have been linked to the development of internalizing and externalizing problem behaviors in preadolescents. selleckchem This study aimed to identify the association these practices had on Mexican preadolescent problem behaviors through Structural Equation Modeling. The sample consisted of 306 elementary students from three public schools in Mexico City (age M = 10, SD = 0.92). Students completed subscales from the Parental Practice Scale, the Alabama Parenting Questionnaire, and the Strengths and Difficulties Questionnaire. Paternal imposition and maternal psychological control were significant predictors for internalizing problems, while inconsistent discipline was a significant predictor of externalizing problems. The results highlight that although parental practice values might differ across cultures, their association to problem behaviors are similar.
To determine the effects of triiodothyronine (T3) intracoronary perfusion in isolated hearts and short-term administration in rats on the left ventricular (LV) phosphorylation patterns of Akt and ERK1/2.
Cardiodynamic and hemodynamic parameters were evaluated in Langendorff-perfused hearts. Left ventricles were used for histomorphometric and Western blot analyses. Short-term hyperthyroidism was established by T3 (500 μg.kg
.d
; subcutaneous injection) for 1 (T3
), 3 (T3
), and 10 (T3
) days.
Isolated hearts receiving T3 perfusion did not modify LV developed pressure, +dP/dt
, -dP/dt
, heart rate, and coronary perfusion pressure compared with vehicle-perfused hearts. P-ERK1/2 and p-Akt levels in LV tissues after 5, 15, or 60 min of T3 or vehicle perfusion were similar. Compared with their time-matched controls, isolated hearts of T3
and T3
rats exhibited LV hypertrophy and increased absolute values of +dP/dt
and -dP/dt
(i.e., positive inotropic and lusitropic effects). P-ERK1/2 decreased i ERK1/2 inhibition; which implies activation of physiological hypertrophy signaling and deactivation of pathological hypertrophy signaling, respectively.
Potentially preventable death from uncontrolled hemorrhage clearly indicates the importance of simple, fast and efficient ways to achieving hemostasis. The aim of this study was to develop a topical formulation of green tea extract for reducing bleeding that can be helpful in hemorrhage control.
Hydroalcoholic extract of green tea was isolated from
and formulated in polyvinyl alcohol (PVA) to achieve two concentrations of 2% and 4% v/v. Folin-Ciocalteau assay was used to determine the total amount of tannins in extract. Rheological behavior of solutions was investigated by measuring viscosity at shear rates of 0-200 sec
. Quantitative and qualitative microbial limit tests and minimum inhibitory concentration (MIC) assay were done. The effect of formulations on bleeding time was evaluated in an animal model.
The total amount of tannin in green tea extract was 3.8% w/w and addition of green tea significantly increased the viscosity of PVA. The results of MIC assay showed that PVA could not inhibit the growth of bacteria, while, 716 µg/ml of green tea and 2860 µg/ml of green tea/PVA 4% inhibited the growth of
and
. In an animal study both 2% and 4% formulations were able to stop hemorrhage approximately at an equal time compared with tranexamic acid (TXA) 50 mg/ml as a control and the lowest bleeding time was 6.4±0.51 sec for green tea/PVA 4%.
Based on our results, the topical formulation of green tea extract in PVA has a great potential for anti-hemorrhage applications.
Based on our results, the topical formulation of green tea extract in PVA has a great potential for anti-hemorrhage applications.
Diabetic cardiomyopathy is a leading factor of high morbidity and mortality in diabetic patients. Our previous results revealed that ginkgolide B alleviates endothelial dysfunction in diabetic rats. This study aimed to investigate the effect of ginkgolide B on cardiac dysfunction and its mechanism in diabetic rats.
Diabetes was induced in rats through the intraperitoneal injection of streptozotocin (STZ). Hemodynamics was monitored to assess cardiac function. Oxidative stress was examined by detecting levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in serum, and expression of sirtuin (SIRT)1, heme oxygenase (HO)-1, and phosphorylated AMPK in the heart. Masson's trichrome staining and expression of transforming growth factor (TGF)-β1, smooth muscle actin (α-SMA), and phosphorylated (p-) Smad2 and Smad3 were used to evaluate cardiac fibrosis. Inflammatory cytokine in serum and levels of p-PI3K, p-Akt, p-p38, and p-JNK in the heart were determined.
Ginkgolide B significantly improved hemodynamics in diabetic rats.