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ley & Sons Ltd.We present a long-term follow-up of the UK chlorambucil, mitoxantrone and dexamethasone (CMD) versus fludarabine, mitoxantrone and dexamethasone (FMD) for untreated advanced, symptomatic follicular lymphoma (FL). This trial was the first to prospectively assess molecular response and the impact on outcomes for 400 patients. The median progression-free survival (PFS) and overall survival (OS) for CMD were 3·6 and 14·6 years vs. 3·0 and 15·7 years for FMD, respectively. Estimates for Restricted Mean Survival Time (RMST) suggested no difference in PFS or OS. For the whole cohort there was a highly significant difference in survival by POD24, with a median OS from a risk-defining event of 3·9 years compared to 13·7 years for all others (RMST P  less then  0·001). Molecular remission was achieved in 25/46 patients (54·3%) in the CMD arm and 20/41 (48·8%) in the FMD arm (P = 0·6). Molecular negativity resulted in median PFS of 5·6 years vs. 2·3 years for molecularly positive (log-rank P  less then  0·001) and median OS not reached versus 12·5 years (log-rank P  less then  0·01). No cases of progression occurred in minimal residual disease (MRD) negative patients after six years of follow-up. Although there was no difference in outcomes between arms, this is the first prospective study to report MRD negativity resulting in significantly improved OS. © 2020 British Society for Haematology and John Wiley & Sons Ltd.The use of organometallic triplet emitters in OLEDs is motivated by the premise of efficient intersystem crossing leading to unit internal quantum efficiencies. However, since most devices are based on solid-state components, an inherent limitation to square planar platinum(II) phosphors is their tendency toward aggregation-based quenching.  We introduce a new class of emissive, four-coordinate Pt(II) species based on the bisimidazolyl carbazolide (BIMCA) ligand that display highly efficient, long-lived solid-state phosphorescence at room temperature. As examples, a set of four BIMCAPt phenyl acetylides are synthesized that emit in the green (l max = 507-540 nm) with >60% quantum yield and millisecond lifetimes. The structures of the resulting species reveal a non-planar structure imposed by steric clashes between BIMCA and the iodo or alkynyl coligand. Ground-state and photophysical characterization are presented. Density-functional theory calculations indicate that the BIMCA ligand dominates the frontier orbitals along with the first Franck-Condon singlet and triplet excited states. NOS modulator © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Nitrite salts are widely presented in food and their hazardous effects have been well documented. In this study, we evaluated the protective capacity of chlorogenic acid (CGA) against sodium nitrite (NaNO2) -induced damage to rat erythrocytes. Two dosing regimens of CGA were undertaken to alleviate the erythrocyte injury induced by NaNO2 . We examined the cell fragility, the level of methemoglobin and oxidative stress parameters of each treated group. In result, as compared to the CGA post-incubation, co-incubation of CGA with NaNO2 decreased the content of advanced oxidation protein products. The protective capacity of CGA was superior to its remedial effect. We infer that the reaction of CGA and NaNO2 may suppress the cytotoxicity of nitrite on erythrocytes and avoid the generation of oxidative stress induced by NaNO2 . Our results suggest a novel diet strategy for preventing the adverse effects of nitrite in those people with exposure to nitrite. PRACTICAL APPLICATIONS Nitrite is ubiquitous in our environment and can also be formed from nitrogenous compounds by microorganisms which exist in the soil, water, and saliva. Several researches have been performed to explore the protection of natural products on the toxic effects of Nitrite. In this study, exogenous chlorogenic acid (CGA) is able to avert the membrane damage, lipid peroxidation, and morphology in nitrite-induced erythrocytes. The protective capacity of CGA shows superior to the remediate effect of CGA against NaNO2 caused damage to erythrocytes. These results suggest a novel diet strategy for preventing the adverse effects of NaNO2 in those people with acute exposure to nitrite. © 2020 Wiley Periodicals, Inc.BACKGROUND Self-reported school satisfaction is an important indicator of child and adolescent well-being. Few studies have examined how disability, gender, and age affect school satisfaction. AIM We sought to determine whether the interaction between disability and gender with regard to self-reported school satisfaction might be specific to particular types of disability and particular ages. METHODS We undertook secondary analysis of Waves 5 and 6 of the UK's Millennium Cohort Study (MCS), a nationally representative sample of children born 2000-2002. MCS is the fourth in the series of British birth cohort studies. RESULT At 11 years of age (n = 12,207), school satisfaction was significantly higher for girls and those without disabilities. By contrast, at 14 (n = 10,933), school satisfaction was significantly higher for boys and those without disabilities. Subsequent analyses of gender moderation of the association between disability and school satisfaction revealed a significant interaction between gender and disabilities associated with mental health and with dexterity, respectively, at 14 years but not at age 11. CONCLUSION These findings will inform future research endeavours, policy, and practice in psychology, education, and other areas associated with child development and disability. © 2020 The Authors. British Journal of Educational Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.Hongjv peel (HP), a spice rich in polyphenols, is generally dried for its preservation. Hot air drying (HAD) at 50°C, 60°C, 70°C, and 80°C was performed in this study to dehydrate HP and it was found that the drying rate increased in line with the increase of HAD temperature. Absorbance analysis showed that HAD induced significant decreases in the total polyphenol content (TPC), total flavonoid content (TFC), and antioxidant activity of HP. Ultra performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis found 18 phytochemicals in the HP, including 11 flavonoids, 6 phenolic acids, and 1 triterpenoid, while multivariate analysis revealed that chlorogenic acid, hesperidin, naringenin, and phloretin in the HP were influenced mainly by HAD. HAD-induced degradations were non-spontaneous, endothermic reactions, consistent with the first-order reaction kinetics. In addition, the results suggest that HAD is more likely to degrade polyphenols that include an ester bond or glucoside. PRACTICAL APPLICATIONS Among the various methods of preservation used to process spices, HAD is still the most effective.