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th the currently available commercial products and by the lack of strong evidence supporting these recommendations.
The practice of intravenous micronutrient administration differs substantially between the three PEPaNIC centres and in comparison with the current guideline recommendations. This deviation is at least partially explained by the inability to provide all recommended amounts with the currently available commercial products and by the lack of strong evidence supporting these recommendations.
Sport performance during competitions is a central goal for athletes, and several factors have been identified that appear to have an association with better performance in different sport disciplines. However, the data are still not conclusive in ultramarathon runners. Accordingly, this study aimed to assess the potential associations between anthropometric, body composition, dietary and training factors and athletic performance in 100-Km elite ultramarathon runners.
Body mass index (BMI), body composition, training volume, Mediterranean dietary adequacy score (MDAS) and "100-Km race competition record" were assessed in 10 elite ultramarathon runners from the Italian Ultramarathon and Trail Association (IUTA) of the Italian national team.
The study sample had a mean age of 41.1±7.59 years and BMI of 21.66±1.11kg/m
. Tacrolimus Female athletes had a lower appendicular skeletal muscle index (ASMI) and 100-Km race competition record, and a higher trunk fat percentage and MDAS compared to males. Correlation analysisgrams based on the increase of training volume as a strategy to improve athletic performance in 100-Km races in this specific population.
Paediatric Crohn's disease (CD) has been associated with undernutrition. Accurate and accessible measures of body composition would provide data to personalise nutritional therapy. We assessed feasibility of MRI-derived measures of psoas cross-sectional area (PCSA) in paediatric CD and correlated with anthropometric and bioelectrical impedance spectroscopy (BIS) measures.
MRI small bowel/pelvis images of patients with CD, aged <18 years, were retrieved. Patients with concurrent anthropometric and BIS measurements were eligible for inclusion. The PCSA at L3 was calculated by two assessors and combined. To assess reproducibility of measures we calculated the coefficient of variation (CoV). Age, height-Z-scores, weight-Z-scores and BIS measures were correlated with PCSA. Using normal paediatric data from CT-scans we derived psoas area Z-scores for our cohort.
10 patients were included. Mean age at MRI scan was 14.6 years (11.7-16.3). PCSA was calculated for all MRI scans. There was high reproducibility al implementation.
and study aims The Sheffield Gastrostomy Score (SGS) was devised to stratify patients by calculating their risk of mortality at 30 days following PEG insertion. The aim was to externally validate the SGS and identify any further predictors of 30-day mortality.
Retrospective review of all PEG insertions performed over a ten year period in our centre. All patients who had a new PEG inserted were identified and the SGS calculated. Additionally, demographic, indication for PEG insertion and other blood results were recorded. Receiver operating characteristic curves were calculated and subsequent univariate and multivariate analysis was performed to identify additional risk factors for 30 day mortality.
The PEG database comprised 1373 patients, of which 808 were suitable for analysis. For each increasing SGS gradation mortality rose, with 4% of those scoring 0 compared to 50% scoring 3. An area under the ROC curve of 0.69 (95% confidence interval 0.64-0.74) indicated good discriminative capacity. Multivariate analysis demonstrated that age ≥60 years (OR=2.1 p=0.016), serum albumin concentrations of 25-34g/l (OR=2.5 p=0.001) or <25g/l (OR=6.8 p<0.001), C-Reactive Protein ≥10mg/l (OR=2.7 p=0.009) and lymphocyte count of <1.5×10
/l (OR=2.0 p=0.004) increased the odds of 30-day mortality, whilst referral for PEG placement whilst an inpatient decreased the risk of death (OR=0.53 p=0.005).
The SGS displayed reasonable predictive ability but the area under the curve is not high enough for routine clinical use. Modelling of further predictors from a multicentre study could provide scope for updating the SGS potentially improving patient selection.
The SGS displayed reasonable predictive ability but the area under the curve is not high enough for routine clinical use. Modelling of further predictors from a multicentre study could provide scope for updating the SGS potentially improving patient selection.
Obesity/overweight is a public health problem globally. Dietary induced inflammation is among the most critical risk factors modulating overweight/obesity. Some people genetically are at higher risk for obesity/overweight. The first gene contributing to conventional forms of human obesity is the FTO gene. The associations between genes like the FTO, inflammation, and obesity/overweight have been investigated in limited studies. We aimed to investigate the association between the dietary inflammatory index (DII) and odds of obesity/overweight in adults with rs9939609 polymorphism of the FTO gene.
A valid 168-item semi-quantitative food frequency questionnaire was used to assess dietary intake. To investigate the role of diet in the development of inflammation, we used the DII, which is predictive of serum inflammatory markers' levels. The Inclusion criteria were defined as body mass index (BMI) from 24.9 to 29.9kg/m
, age from 20 to 45 years, not participating in a weight management program during two pas niacin, and zinc, manganese, and selenium and recommending a reduction in the most inflammatory factors of diet, including saturated and trans fatty acids, could be a new strategy in the treatment and or controlling of obesity/overweight as a public health problem.
Dietary induced inflammation significantly is related to odds of overweight in adults with rs9939609 polymorphism of the FTO gene. Suggesting an anti-inflammatory diet containing vitamins and minerals such as vitamin A, thiamine, niacin, and zinc, manganese, and selenium and recommending a reduction in the most inflammatory factors of diet, including saturated and trans fatty acids, could be a new strategy in the treatment and or controlling of obesity/overweight as a public health problem.