NTerminomics Approaches for Protease Substrates Profiling

odicals, Inc.Autologous stem cell transplantation (ASCT) is feasible and effective in selected older patients with Multiple Myeloma but specific criteria for evaluating ASCT eligibility in elderly patients are lacking. We evaluated 131 patients aged 65-75 considered for ASCT at our center Charlson Comorbidity Index (CCI), Hematopoietic cell transplantation comorbidity index (HCT-CI) and IMWG frailty score were obtained at diagnosis, but the intensity of treatment was left to physician's choice. The scores and age's impact on outcome was analyzed 85 patients were judged transplant eligible, whereas 46 patients received a less intensive treatment (median follow up 27 months). No patients classified as FRAIL had been considered eligible to ASCT with a worse outcome compared to FIT and UNFIT patients (median PFS 7,9 vs 32,9 and 29,6 months; p less then 0.0001). PFS was superior in the ASCT group (35,6 vs 19,9 months, p0,013). In the ASCT group, PFS was better in patients aged 65-69 years than in patients ≥70 (51,5 vs 27,7 months, p 0,0037). Indeed, in UNFIT patients aged ≥70 the PFS of the ASCT group was comparable to NO ASCT group (18 vs 27 months, p 0,33) whereas in UNFIT patients aged 65-69 PFS was superior in the ASCT group 43,3 vs 18,4 months, p 0.01. ISS III and impaired functional status independently affected PFS in a multivariate analysis (p 0.011 and p 0.006). While CCI and HCT-CI did not predict different outcome in ASCT patients, the IMWG frailty score would be of help in identifying UNFIT patients aged 70-75 whose outcome with ASCT selected by clinical judgment was no better than with less intensive treatments This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.High levels of infant crying place families at risk for disrupted relationships, parenting stress, and even for child maltreatment. We conducted an evaluation of the Fussy Baby Network® (FBN), a program supporting families struggling with infant crying and related concerns. The study contrasted 29 families who sought help from FBN with 27 families with excessively crying infants who did not seek services. Researchers measured parenting self-efficacy, depression, and stress in each group before and after the intervention. Results from hierarchical multiple regression analysis indicated greater improvements over time in parenting self-efficacy for parents receiving FBN services. Furthermore, the greater improvements in parenting self-efficacy in the intervention group were not directly attributable to reductions in infant crying. These findings provide preliminary evidence that the FBN approach may be effective at boosting the confidence of parents struggling with caring for their infants. Future research with larger samples with baseline equivalence and stronger research designs should explore this intervention further. This study also suggests that interventions for families with excessively crying infants should move beyond the focus of reducing infant crying to a broader strategy of supporting parents and strengthening relationships between parents and their infants to build parenting capacity. © 2020 Michigan Association for Infant Mental Health.AIM To report the Card Games approach used to study men's talk about their risk for prostate cancer and as a method of data collection to analyse patterns of talk amongst distinct cultural groups. DESIGN A constructivist grounded theory approach using focus groups to analyse men's social talk about prostate cancer METHODS Data were collected using three focus groups with African-Caribbean, Somali and White British men. The focus groups were conducted in a location of the men's choice with a focus group facilitator and observer. Four Card Games were given to the men to encourage social talk. RESULTS The African-Caribbean men had the most democratic talk with the use of agreement and disagreement and the Somali men were the most inclusive of others and used the most humour. The White British men were competitive in their talk and the least inclusive of each other's views. CONCLUSION The Card Games revealed differences in the pattern of talk, which provided insight into how men may use social talk to develop their understanding of prostate cancer risk. This is useful for healthcare professionals as it provides a grounding for structuring discussions with men about prostate cancer, whilst understanding of how risk-related knowledge may be reconstructed in social talk and interactions. IMPACT The methodology discussed in this paper addressed the use of focus group to analyse talk of men from culturally diverse groups. Terephthalic mw The use of Card Games allowed the talk between the men to take centre stage and this allowed differences in the social talk of the men to become apparent. The use of this methodology could have an impact on approaches to researching cultural understandings of cancer risk, which may provide evidence on effective delivery of sociocultural relevant health education relating to cancer screening. This article is protected by copyright. All rights reserved.Invasive fungal infections (IFI) are a significant source of morbidity and mortality for patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Given the heterogeneity of the population receiving hypomethylating agents (HMA), it is difficult for clinicians to accurately assess their patients' risk of infection. Literature on the incidence of IFI following HMA is limited to several studies of azacitidine. The primary objective of this retrospective study was to establish the incidence of IFI in HMA treated AML/MDS patients at a large U.S. comprehensive cancer center. Secondary objectives included comparing incidence of IFI among pre-specified subgroups to identify potential risk factors for IFI. Two hundred three patients with AML, intermediate to very high risk MDS or chronic myelomonocytic leukemia who received at least two cycles of HMA were included. The incidence of IFI, as defined by the European Organization for Research and Treatment of Cancer / Invasive Fungal Infections Cooperative Group criteria, was 9.