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The requirement of levothyroxine was similar at baseline (48.6 ±16.9 µg vs. 49.6 ±19.5 µg, p-value 0.80) and at the endpoint (48.3 ±17.2 µg vs. 51.9 ±18.0 µg, p-value 0.46) in both groups. At the study end, 25 (60%) patients in group A and 17 (40%) in group B preferred bedtime dosing of levothyroxine.
We found an equal efficacy of bedtime intake compared to early morning intake of levothyroxine in maintaining an euthyroid state in children with hypothyroidism. Further studies are required to see if bedtime levothyroxine administration improves the quality of life of patients.
We found an equal efficacy of bedtime intake compared to early morning intake of levothyroxine in maintaining an euthyroid state in children with hypothyroidism. Further studies are required to see if bedtime levothyroxine administration improves the quality of life of patients.
Osteoporosis is apreventable progressive metabolic disease. Girls have an increased risk of occurrence of osteoporosis in their old age. The BASNEF model can be employed to change behaviors related to health. The BASNEF model was employed to determine the predictors of osteoporosis preventive behaviors among adolescent girls.
This cross-sectional study was carried out on 209 adolescent girls selected from high schools in the Quchan County in 2016 using path analysis by stratified sampling. The data was collected through ademographic questionnaire and a52-item researcher-made questionnaire, based on the BASNEF model constructs. The data was analyzed using Shapiro-Wilk test, bootstrapping, and path analysis.
The average age of the students was 16.10 ±0.59. The results of path analysis showed that Model 1 matched the BASNEF model relationships completely; however, it could not predict osteoporosis preventive behaviors. The constructs of Model 2 (modified) was able to predict 50% of variances in osteoporosis preventive behaviors. There were positive and direct relationships between the following pairs of constructs knowledge and attitudes (B=0.23, p<0.001); attitudes and the intention of osteoporosis preventive behaviors (B=0.37, p<0.001); subjective norms and the intention of osteoporosis preventive behaviors (B=0.53, p<0.001); behavioral intention and osteoporosis preventive behaviors (B=0.36, p<0.001); subjective norms and osteoporosis preventive behaviors (B=0.33, p<0.001), and enabling factors and osteoporosis preventive behaviors (B=0.29, p<0.001).
The community health nurse can use the constructs of the BASNEF model to change the osteoporosis preventive behaviors like knowledge, attitudes subjective norms and enabling factors.
The community health nurse can use the constructs of the BASNEF model to change the osteoporosis preventive behaviors like knowledge, attitudes subjective norms and enabling factors.
Diabetic ketoacidosis is the most important metabolic emergency in children. Children mimic many syndromes with acombination of nonspecific symptoms during the COVID-19 pandemic. Many syndromes are triggered by changes in children's body conditions. Reporting specific cases can improve the diagnosis process. The present study reports an 18-month-old paediatric case of COVID-19 who presented ketoacidosis (DKA) symptoms.
The case is an 18-month-old child with fever and diarrhoea from 3 days before, who did not respond to outpatient treatment. On the day of the visit, he suffered from deep and abdominal breathing and decreased level of consciousness and sugar levels at admission of 420 mg/dl. He was then admitted with the initial diagnosis of DKA and had apositive PCR test result for COVID-19.
Considering the non-specific symptoms of COVID-19, general practitioners and paediatricians are recommended that special attention be paid to these symptoms, especially those that are similar to life-threatening syndromes. They also should not easily ignore these symptoms and follow up patients and their recovery status and, if patients do not recover, consider the risk of COVID-19 given the current COVID-19 pandemic.
Considering the non-specific symptoms of COVID-19, general practitioners and paediatricians are recommended that special attention be paid to these symptoms, especially those that are similar to life-threatening syndromes. They also should not easily ignore these symptoms and follow up patients and their recovery status and, if patients do not recover, consider the risk of COVID-19 given the current COVID-19 pandemic.There is little evidence regarding the best treatment in case of dilated cervix and exposed membranes in twins. Current options for its management include vaginal progesterone, cervical cerclage and cervical pessary, but none of them had shown effectiveness compared to expectant management. We presented a case of twin pregnancy at 22 6/7 weeks' gestation admitted to the hospital because of cervical insufficiency with bulging of membranes. An Arabin pessary was positioned after a failed attempt of cervical cerclage and no antibiotic was given in absence of signs of infection. Cesarean delivery was performed at 24 weeks' gestation because of spontaneous preterm labor and spontaneous rupture of membranes with the first baby in a transverse lie position. At the uterus section, the first baby was stillborn, with Arabin pessary strictly adherent to his ecchymotic head, while the second baby was born alive. After diagnostic histopathological and microbiological investigations, we hypothesized that the first twin died for funisitis/sepsis and mechanical insult due to the strict adhesion of the pessary to the fetal head. We concluded that in case of bulging membranes and dilated cervix, antibiotic treatment should be evaluated, also in absence of signs/symptoms of infection or suspicion of rupture of the membranes, and pessary insertion should be avoided, namely at second trimester, because of the risk of its dislocation inside the uterus when contractions start and potential hurt to extremely preterm fetus.
Existing guidelines do not settle on a specific length to indicate surgical incision of subseptations because of differences in the four published diagnostic methods AFS-10 mm classification, 1988/2003, ESHRE-ESGE classification, 2013, ASRM criteria, 2016- and 5.9-mm length cut-off, 2017. With this review and data analysis we sought to identify the classification method with the most accurate association with early pregnancy loss, as to identify a subseptation length cut-off to indicate surgical correction.
We performed an exhaustive literature search of PubMed (MEDLINE), Embase, and Cochrane Library databases until April 20, 2020 (limited to articles published in English) of the terms "uterine septum," "arcuate uterus," "subseptation," "Müllerian anomalies," from 1980-2020. After identifying all the available classifications for uterine subseptations, we performed a secondary data analysis of our departmental database on uterine subseptations and compared the identified classification criteria. BTK inhibitor concentration Measurement of the subseptation's length was obtained on 2-D and 3-D ultrasound in accordance with the different methods.