Pemphigus foliaceus in Arabian oryx Oryx leucoryx

ts non cimentés et l’utilisation de routine d’allogreffes. La nature complexe de ces cas justifie que l’on fasse appel à une équipe chevronnée pour l’arthroplastie.in English, French Contexte Il existe peu d’études sur le taux de survie et la fonction des prothèses totales de genou (PTG) à charnière, et, à notre connaissance, il n’y a pas encore d’étude publiée sur la prothèse Legion HK Hinge Knee (Smith & Nephew), qui guide le mouvement de l’articulation. Cette étude visait à déterminer le taux de survie à 2 ans de cette PTG à charnière moderne dans un seul établissement et à évaluer la fonction du genou et la satisfaction des patients après l’opération. Méthodes Cette étude rétrospective portait sur des patients qui avaient reçu la PTG Legion HK guidant le mouvement lors d’une première opération ou d’une chirurgie de révision entre octobre 2011 et mars 2016 dans un centre de soins tertiaires du Manitoba, au Canada. On a évalué la fonction préopératoire et postopératoire du genou à l’aide du score Oxford d’évaluation du genou à 12 questions ainsi que la satisfaction des patients après l’opération. Résultats Trente-neuf arthroplasties totales du genou (38 patients) ont été retenues pour l’étude 12 cas de première opération et 27 chirurgies de révision. En tout, 3 chirurgies de révision et 4 complications périopératoires ont été notées lors d’une consultation de suivi se déroulant en moyenne à 29,1 mois. Le taux de survie à 2 ans de la PTG à charnière Legion HK était de 90,7 %. Les scores de fonction du genou se sont grandement améliorés après l’opération, et la majorité des patients se sont dit satisfaits ou très satisfaits lors de tous les suivis. Conclusion Le taux de survie d’une PTG à charnière moderne guidant le mouvement est similaire à celui des autres prothèses à charnière étudiées dans la littérature. La prothèse a permis une amélioration fonctionnelle importante après l’opération lorsqu’elle était utilisée dans le cadre d’une première arthroplastie totale du genou complexe ou d’une chirurgie de révision.Ground walking in humans is typically stable, symmetrical, characterized by smooth heel-to-toe ground contact. Previous studies on children with autism spectrum disorder (ASD) identified various gait abnormalities. However, they produced inconsistent findings, particularly for the occurrence of toe walking and gait symmetry between feet, owing to their reliance on retrospective reports, visual analysis of videos, or kinematic analysis of the gait. The present study examined gait functions in children with ASD using plantar pressure that quantified foot-ground interaction with high spatial and temporal resolutions. Fifty-eight 4-6-year-old children with ASD (12 low-functioning and 46 high-functioning autism) and 28 age-matched typically developed children walked straight 6 m at their preferred speed for 10 repetitions. We found that both ASD groups walked with more flat-footed contact pattern, more left-right asymmetry, and larger step-to-step variability than their controls. Furthermore, these abnormal gait characteristics were related to social impairments measured by the Autism Spectrum Quotient and Social Responsive Scale, supporting a close association between impaired motor coordination and core symptoms of autism. LAY SUMMARY We examined gait functions among children with autism by measuring their foot plantar pressure during simple straight walking. Children with ASD walked with a characteristic foot-ground contact pattern with inappropriate contact forces and large step-to-step variability when compared with their age-matched controls. These walking abnormalities were dependent on their social impairments but independent from their intelligence, indicating a close relationship between atypical motor coordination and core symptoms of autism. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.Microcarriers, including crosslinked porous gelatin beads (Cultispher G) are widely used as cell carriers for cell therapy applications. Microcarriers can support a range of adherent cell types in stirred tank bioreactor culture, which is scalable up to several thousands of liters. Cultispher G in particular is advantageous for cell therapy applications because it can be dissolved enzymatically, and thus cells can be harvested without the need to perform a large-scale cell-bead filtration step. This enzymatic dissolution, however, is challenged by the slow degradation of the carriers in the presence of enzymes as new extracellular matrix is being deposited by the proliferating cells. This extended dissolution timelimits the yield of cell recovery while compromising cellular viability. We report herein the development of crosslinked porous gelatin beads that afford rapid, stimuli-triggered dissolution for facile cell removal using human mesenchymal stem cells (hMSC) as a model system. We successfully fabricated redox-sensitive beads (RS beads) and studied their cell growth, dissolution time and cell yield, compared to regular gelatin-based beads (Reg beads). We have shown that RS beads allow for much faster dissolution compared to Reg beads, supporting better hMSC detachment and recovery following 8 days of culture in spinner flasks, or in 3L bioreactors. These newly synthesized RS beads show promise as cellular microcarriers and can be used for scale-up manufacturing of different cell types while providing on-demand degradation for facile cell retrieval. © 2020 Wiley Periodicals, Inc.Arterial damage of large arteries, addressed as c-f PWV, is recognized as independent predictor for future cardiovascular disease. The aim of this study was to systematically investigate the association of the four hypertension phenotypes with carotid-femoral pulse wave velocity (c-f PWV), in untreated patients. PubMed and Cochrane Library were searched to identify studies comparing c-f PWV levels between normotensives, sustained hypertensives, white-coat hypertensives (WCH), and masked hypertensives (MH). learn more Meta-analysis was performed to compare the difference c-f PWV levels between these groups. Newcastle-Ottawa quality assessment scale for cross-sectional studies was used to assess study quality. MH and WCH patients had significantly increased c-f PWV values compared to the normotensive groups (d = 0.96 m/s, 95% CI 0.49-1.42; I2 = 85%, P  less then  .01 for MH and d = 0.85 m/s, 95% CI 0.48-1.22; I2 = 89%, for WCH). Moreover, the sustained hypertensive population was found to have significantly increased values of c-f PWV compared to MH (d = -0.