Precision diagnostics throughout medical microbiology

These investigations present a contribution to the basic understanding of plasmon-enhanced enzyme-like reaction and provided an insight into the optimization of the SuOx mimetic performance of nanomaterials.Mechanical stability of hybrid organic-inorganic perovskites (HOIPs) is essential to achieve long-term durable HOIP-based devices. While HOIPs in two-dimensional (2D) form offer numerous options in the structure and composition to tune their mechanical properties, little is known about the structure-mechanical-property relationship in this family of materials. Here, we investigated a series of 2D lead halide HOIPs by nanoindentation to explore the impact of critical factors controlling the properties of both the organic and inorganic layers on the materials' out-of-plane mechanical performance. We find that the lead-halide bond in the inorganic framework can significantly influence the mechanical properties of 2D Ruddlesden-Popper (RP) HOIPs with n = 1. Like 3D HOIPs, stronger lead-halide bond strength leads to a higher Young's modulus in these 2D HOIPs, i.e., E⊥Cl ≳ E⊥Br > E⊥I. In contrast, the hardness of 2D RP HOIPs follows a trend of HBr2D > HCl2D > HI2D, which is different from that found in 3D HOIPs, pr providing guidelines and inspirations to achieve material design with required mechanical properties for applications.Lightweight structural materials are critical in construction and automobile applications. In past centuries, there has been great success in developing strong structural materials, such as steels, concrete, and petroleum-based composites, most of which, however, are either too heavy, high cost, or nonrenewable. Biosourced composites are attractive alternatives to conventional structural materials, especially when high mechanical strength is presented. Here we demonstrate a strong, lightweight bio-based structural material derived from bamboo via a two-step manufacturing process involving partial delignification followed by microwave heating. Partial delignification is a critical step prior to microwave heating as it makes the cell walls of bamboo softer and exposes more cellulose nanofibrils, which enables superior densification of the bamboo structure via heat-driven shrinkage. Additionally, microwave heating, as a fast and uniform heating method, can drive water out of the bamboo structure, yet without destroying the material's structural integrity, even after undergoing a large volume reduction of 28.9%. The resulting microwave-heated delignified bamboo structure demonstrates outstanding mechanical properties with a nearly 2-times improved tensile strength, 3.2-times enhanced toughness, and 2-times increased bending strength compared to natural bamboo. Additionally, the specific tensile strength of the modified bamboo structure reaches 560 MPa cm3 g-1, impressive given that its density is low (1.0 g cm-3), outperforming common structural materials, such as steels, metal alloys, and petroleum-based composites. These excellent mechanical properties combined with the resource abundance, renewable and sustainable features of bamboo, as well as the rapid, scalable manufacturing process, make this strong microwave-processed bamboo structure attractive for lightweight, energy-efficient engineering applications.Though emerging as a promising therapeutic approach for cancers, the crucial challenge for photodynamic therapy (PDT) is activatable phototoxicity for selective cancer cell destruction with low "off-target" damage and simultaneous therapeutic effect prediction. Here, we design an upconversion nanoprobe for intracellular cathepsin B (CaB)-responsive PDT with in situ self-corrected therapeutic effect prediction. The upconversion nanoprobe is composed of multishelled upconversion nanoparticles (UCNPs) NaYF4Gd@NaYF4Er,Yb@NaYF4Nd,Yb, which covalently modified with an antenna molecule 800CW for UCNPs luminance enhancement under NIR irradiation, photosensitizer Rose Bengal (RB) for PDT, Cy3 for therapeutic effect prediction, and CaB substrate peptide labeled with a QSY7 quencher. The energy of UCNPs emission at 540 nm is transferred to Cy3/RB and eventually quenched by QSY7 via two continuous luminance resonance energy transfer processes from interior UCNPs to its surface-extended QSY7. The intracellular CaB specifically cleaves peptide to release QSY7, which correspondingly activates RB with reactive oxygen species (ROS) generation for PDT and recovers Cy3 luminance for CaB imaging. UCNPs emission at 540 nm remains unchanged during the peptide cleavage process, which is served as an internal standard for Cy3 luminance correction, and the fluorescence intensity ratio of Cy3 over UCNPs (FI583/FI540) is measured for self-corrected therapeutic effect prediction. The proposed self-corrected upconversion nanoprobe implies significant potential in precise tumor therapy.Spinel Li4Ti5O12 is considered as a promising anode material for long-life lithium ion batteries due to the negligible volumetric variation during the insertion and extraction of the Li ion. Phase transition is an inevitable process during the migration of the Li ion and the transition process and mechanism need detailed investigation down to atomic scale. In this study, we investigated the behavior and mechanism on the phase transition of Li4Ti5O12 through in situ transmission electron microscopy. It has been found that the spinel structured Li4Ti5O12 was gradually transformed to rocksalt structured under electron beam irradiation. A sharp interface with an epitaxial relationship was observed between the transformed rocksalt phase and the parent spinel phase. Furthermore, the heterostructure with different crystal structures of Li4Ti5O12 has been precisely tailored with electron beam irradiation. Our detailed in situ TEM results and theoretical calculations lead to unprecedented level on understanding of phase transition mechanism in Li4Ti5O12. This study demonstrates a possible approach to precisely engineer the crystal structure of materials and to realize well-designed heterostructure in electrode materials.OBJECTIVE To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19). METHODS The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Central Hospital from January 21, 2020 to March 20, 2020 were retrospectively analyzed. RESULTS Of the 48 suspected cases, 18 were diagnosed with COVID-19, and 30 were excluded. Each of the confirmed cases were discussed among MDT for 2 to 12 times with an average of (4.7±3.2) times; while for non-COVID-19 patients were discussed for 2 to 4 times with an average of (2.3±0.6) times per case. With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. learn more Except one transferred patient, all 17 confirmed COVID-19 patients were cured and discharged; there was no cross-infection occurred in suspected patients during the hospitalization; there were no deaths and no medical staff infections.