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This study investigated the in vitro anticancer potential of phytochemical constituents isolated from the methanolic extract of Eriocephalus africanus. One flavanone (hesperidin) and two flavones (luteolin and apigenin) were isolated for the first time from the plant using column chromatography. Standard MTT assay was used to evaluate the effect of the constituents on cell viability in MCF-7, A549, HepG2 and normal HEK 293 cell lines. The flavonoids decreased cell viability in a dose dependent manner in all tested cell lines. Hesperidin and luteolin were more sensitive against MCF-7, with EC50 values of 62.57 µg/mL and 70.34 µg/mL, respectively and apigenin showed the most potent activity against HepG2 (EC50 = 11.93 µg/mL). The results revealed E. africanus to be a rich source of flavonoids and natural anticancer agents, which could potentially be used in the development of new therapeutics for cancer treatment.An electrochemical quartz crystal microbalance is described, which achieves a time resolution down to 100 μs. Accumulation and averaging over a few hours bring the noise down to about 30 mHz. The application examples are pH-driven viscosity changes in albumin solutions. The pH was switched with the electrode potential. The characteristic response time is in the millisecond range. The focus is on experimental aspects as well as advantages and limitations of the technique.The use of nanoparticles for the controlled drug delivery to cells has emerged as a good alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging. In contrast, QDs may also pose risks to human health and the environment under certain conditions. Here, we demonstrated that a unique combination of nanocrystals core components (Ag-In-Zn-S) would eliminate the toxicity problem and increase their biomedical applications. The alloyed quaternary nanocrystals Ag-In-Zn-S (QDgreen, Ag1.0In1.2Zn5.6S9.4; QDred, Ag1.0In1.0Zn1.0S3.5) were used to transport new unsymmetrical bisacridine derivatives (UAs, C-2028 and C-2045) into lung H460 and colon HCT116 cancer cells for improving the cytotoxic and antitumor action of these compounds. UAs were coupled with QD through physical adsorption. The obtained results clearly indicate that the synthesized nanoconjugates exhibited higher cytotoxic activity than unbound compoundotecting effects on normal cells.In this work a new curvilinear coordinate system is presented for the comprehensive description of polytopal rearrangements of $N$-coordinate compounds ($N$ = 4-7) and systems containing an $N$-coordinate subunit. It is based on normal vibrational modes and a natural extension of the Cremer-Pople puckering coordinates (J. Am. Chem. https://www.selleckchem.com/products/tak-715.html Soc. 1975, 97, 1354) and the Zou-Izotov-Cremer deformation coordinates (J. Phys. Chem. A 2011, 115, 8731) for ring structures to $N$-coordinate systems. We demonstrate that the new curvilinear coordinates are ideal reaction coordinates describing fluxional rearrangement pathways by revisiting the Berry pseudorotation and the lever mechanism in sulfur tetrafluoride, the Berry pseudorotation and two Muetterties' mechanisms in pentavalent compounds, the chimeric pseudorotation in iodine pentafluoride, Bailar and Ray-Dutt twists in hexacoordinate tris-chelates as well as the Bartell mechanism in iodine heptafluoride. The results of our study reveal that this dedicated curvilinear coordinate system can be applied to most coordination compounds opening new ways for the systematic modeling of fluxional processes.Crystal growth of semiconductor nanowires from a liquid droplet depends on the stability of this droplet's liquid-solid interface. Because of the assisting property of the droplet, growth will be hindered if the droplet is displaced onto the nanowire sidewalls. Using real-time observation of such growth by in situ transmission electron microscopy combined with theoretical analysis of the surface energies involved, we observe a reoccurring truncation at the edge of the droplet-nanowire interface. We demonstrate that creating a truncation widens the parameter range for having a droplet on the top facet, which allows continued nanowire growth. Combining experiment and theory provides an explanation for the previously reported truncation phenomenon of the growth interface based only on droplet wetting dynamics. In addition to determining the fundamental limits of droplet-assisted nanowire growth, this allows experimental estimation of the surface tension and the surface energies of the nanowire such as the otherwise metastable wurtzite GaAs 101̅0 facet.We present tests of the recent M11plus Minnesota density functional for a broad range of main-group and transition-metal chemistry databases, most of which were not used in in the construction of any of the Minnesota functionals. M11plus is a range-separated hybrid meta functional combining long-range nonlocal Hartree-Fock exchange with nonlocal rung-3.5 correlation. M11plus performs well for main-group thermochemistry, kinetics, and noncovalent interactions and especially well for radical species. It is numerically well behaved, it has a computational cost that is ∼1.2 to 1.5 times that of M11 in realistic calculations, and it is particularly accurate for triplet excited states, which is a difficult challenge for density functional approximations. The results show that nonlocal rung-3.5 correlation is a broadly useful ingredient for improving the performance of density functional approximations.Two-dimensional (2D) halide perovskites have displayed unique emission properties, making them potential candidates for next-generation light-emitting devices. Here, we combine nonadiabatic molecular dynamics and time-domain density functional theory to investigate the fundamental mechanisms of carrier recombination processes. Considering monolayer bromide perovskites with dissimilar organic spacer molecules, n-butylammonium (BA) and phenylethylammonium (PEA) cations, we find a strong correlation between temperature-induced structural fluctuations and nonradiative carrier recombination rates in these materials. The more flexible geometry of (BA)2PbBr4 compared to that of (PEA)2PbBr4, results in faster electron-hole recombination and shorter carrier lifetime, diminishing the photoluminescence quantum yield for softer 2D perovskites. Reduced structural fluctuations in relatively rigid (PEA)2PbBr4 not only indicate of a longer carrier lifetime but also suggest a narrower emission line width, implying a higher purity of the emitted light.