Psychological strain hinders IL22driven protective intestine mucosal defense against colonising pathobionts

An aminopropyl isobutyl polyhedral oligosilsesquioxane (NH2-POSS) surface-modified Nafion membrane has been designed by chemical grafting for vanadium redox flow batteries (VRFBs). NH2-POSS is a cage-like macromer consisting of an inorganic Si8O12 core surrounded by seven inert isobutyl groups and one active aminopropyl group. The sulfonic acid groups on the surface of Nafion can be activated by 1,1-carbonyldiimidazole for further modification with NH2-POSS. Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) prove that NH2-POSS has been successfully grafted on the surface of a Nafion 115 membrane. Although the proton conductivity decreases slightly, the organic-inorganic hybrid membranes display enhanced ion selectivity and excellent dimensional stability with lower water uptake and swelling ratio than Nafion 115. Moreover, two-dimensional-grazing incidence X-ray diffraction (2D-GIXRD) reveals that the introduction of NH2-POSS forms a POSS layer on the surface of the membrane and narrows the space of Nafion clusters, which helps to block VO2+ permeation. A VRFB with the surface-modified Nafion membrane displays an outstanding performance with an average Coulombic efficiency (CE) of 98.7% and energy efficiency (EE) of 84.5% at a current density of 80 mA cm-2, superior to those of the Nafion 115 membrane (CE = 95.7%, EE = 81.7%). Furthermore, the cell holds a high capacity retention of 49.2% after 1000 charge-discharge cycles, in contrast to that of 41.9% for the cell with Nafion 115 after only 200 cycles. The results suggest that the surface-modified hybrid membrane is a promising strategy to overcome the vanadium ion crossover in VRFBs.Chemical isotope labeling liquid chromatography mass spectrometry (LC-MS) is an emerging metabolomic strategy for the quantification and characterization of small molecular compounds in biological samples. However, its subsequent data analysis is not straightforward due to a large amount of data produced and interference of biological matrices. In order to improve the efficiency of searching and identification of target endogenous metabolites, a new software tool for nontargeted metabolomics data processing called MS-IDF was developed based on the principle of a narrow mass defect filter. The developed tool provided two function modules, including IsoFinder and MDFinder. The IsoFinder function module applied a conventional peak extraction method by using a fixed mass differences between the heavy and light labels and by the alignment of chromatographic retention time (RT). On the other hand, MDFinder was designed to incorporate the accurate mass defect differences between or among stable isotopes in the peak extraction process. By setting an appropriate filter interval, the target metabolites can be efficiently screened out while eliminating interference. Notably, the present results showed that the efficiency in compound identification using the new MDFinder module was nearly doubled as compared to the conventional IsoFinder method (an increase from 259 to 423 compounds). The Matlab codes of the developed MS-IDF software are available from github at https//github.com/jydong2018/MS_IDF. Based on the MS-IDF software tool, a novel and effective approach from nontargeted to targeted metabolomics research was developed and applied to the exploration of potential primary amine biomarkers in patients with schizophrenia. With this approach, potential biomarkers, including N,N-dimethylglycine, S-adenosine-l-methionine, dl-homocysteine, and spermidine, were discovered.In conventional classification, soft robots feature mechanical compliance as the main distinguishing factor from traditional robots made of rigid materials. Recent advances in functional soft materials have facilitated the emergence of a new class of soft robots capable of tether-free actuation in response to external stimuli such as heat, light, solvent, or electric or magnetic field. this website Among the various types of stimuli-responsive materials, magnetic soft materials have shown remarkable progress in their design and fabrication, leading to the development of magnetic soft robots with unique advantages and potential for many important applications. However, the field of magnetic soft robots is still in its infancy and requires further advancements in terms of design principles, fabrication methods, control mechanisms, and sensing modalities. Successful future development of magnetic soft robots would require a comprehensive understanding of the fundamental principle of magnetic actuation, as well as the physical properties and behavior of magnetic soft materials. In this review, we discuss recent progress in the design and fabrication, modeling and simulation, and actuation and control of magnetic soft materials and robots. We then give a set of design guidelines for optimal actuation performance of magnetic soft materials. Lastly, we summarize potential biomedical applications of magnetic soft robots and provide our perspectives on next-generation magnetic soft robots.Carbon quantum dots (CQDs) represent a class of carbon materials exhibiting photoresponse and many potential applications. Here, we present a unique property that dissolved CQDs capture large amounts of molecular oxygen from the air, the quantity of which can be controlled by light irradiation. The O2 content can be varied between a remarkable 1 wt % of the CQDs in the dark to nearly half of it under illumination, in a reversible manner. Moreover, O2 depletion enhances away from the air-solution interface as the nearby CQDs quickly regain them from the air, creating a pronounced concentration gradient in the solution. We elucidate the role of the CQD functional groups and show that excitons generated under light are responsible for their tunable adsorbed-oxygen content. Because of O2 enrichment, the photocatalytic efficiency of the CQDs toward oxidation of benzylamines in the air is the same as under oxygen flow and far higher than the existing photocatalysts. The findings should encourage the development of a new class of oxygen-enricher materials and air as a sustainable oxidant in chemical transformations.The development of high-efficiency and durable bifunctional electrocatalysts for both the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is critical for the widespread application of rechargeable zinc-air (Zn-air) batteries. This calls for rational screening of targeted ORR/OER components and precise control of their atomic and electronic structures to produce synergistic effects. Here, we report a Mn-doped RuO2 (Mn-RuO2) bimetallic oxide with atomic-scale dispersion of Mn atoms into the RuO2 lattice, which exhibits remarkable activity and super durability for both the ORR and OER, with a very low potential difference (ΔE) of 0.64 V between the half-wave potential of ORR (E1/2) and the OER potential at 10 mA cm-2 (Ej10) and a negligible decay of E1/2 and Ej10 after 250 000 and 30 000 CV cycles for ORR and OER, respectively. Moreover, Zn-air batteries using the Mn-RuO2 catalysts exhibit a high power density of 181 mW cm-2, low charge/discharge voltage gaps of 0.69/0.96/1.38 V, and ultralong lifespans of 15 000/2800/1800 cycles (corresponding to 2500/467/300 h operation time) at a current density of 10/50/100 mA cm-2, respectively. Theoretical calculations reveal that the excellent performances of Mn-RuO2 is mainly due to the precise optimization of valence state and d-band center for appropriate adsorption energy of the oxygenated intermediates.Nitrous acid (HONO) is an important component of the global nitrogen cycle and can regulate the atmospheric oxidative capacity. Soil is an important source of HONO. [HONO]*, the equilibrium gas-phase concentration over the aqueous solution of nitrous acid in the soil, has been suggested as a key parameter for quantifying soil fluxes of HONO. However, [HONO]* has not yet been well-validated and quantified. Here, we present a method to retrieve [HONO]* by conducting controlled dynamic chamber experiments with soil samples applied with different HONO concentrations at the chamber inlet. We show a bi-directional soil-atmosphere exchange of HONO and confirm the existence of [HONO]* over soil when [HONO]* is higher than the atmospheric HONO concentration, HONO will be released from soil; otherwise, HONO will be deposited. We demonstrate that [HONO]* is a soil characteristic, which is independent of HONO concentrations in the chamber but varies with different soil water contents. We illustrate the robustness of using [HONO]* for quantifying soil fluxes of HONO, whereas the laboratory-determined chamber HONO fluxes can largely deviate from those in the real world for the same soil sample. This work advances the understanding of the soil-atmosphere exchange of HONO and the evaluation of its impact on the atmospheric oxidizing capacity.Two-dimensional (2D) molybdenum disulfide (MoS2) has emerged as a prospective candidate for photodetection. However, due to the surface defects formed during the synthesis, the low photoresponse of 2D MoS2 photodetectors restricts its practical applications. Here, we developed a hybrid plasmonic structure that integrates MXene nanoparticles (MNPs) and 2D MoS2. With the introduction of MNPs, light waves are concentrated on MoS2 nanosheets via a strong localized surface plasmon resonance. Consequently, MNPs-decorated MoS2 photodetectors exhibit an improved photoresponse, including a higher responsivity (20.67 A/W), a larger detectivity of 5.39 × 1012 Jones, and a maximum external quantum efficiency of over 5000%. A 150-fold enhanced detectivity (2.33 × 1012 Jones) was achieved under 635 nm light illumination in the optimized device. These results provide an alternative approach for improving the photoresponse of MoS2 photodetectors.In this article, we synthesized a Yb3+-doped two-dimensional (2-D) upconverting Tb metal-organic framework (Tb-MOF) (hereinafter referred to as Tb-UCMOF) by a one-step solvothermal method. The synthesized Tb-UCMOF is composed of stacks of 2-D nanosheets with an average width distributed between 250 and 300 nm, and these nanosheets can be exfoliated by a simple liquid ultrasound method. The structural characteristics of this flaky particle accumulation are confirmed by the type IV adsorption-desorption isotherm with a H3-type adsorption hysteresis loop, and the Brunauer-Emmett-Teller surface of Tb-UCMOF is 143.9257 m2·g-1. Tb-UCMOF has characteristic emissions of Tb3+ which are located at 490, 545, 585, and 621 nm under 980 nm excitation. The upconverting luminescence mechanism is attributed to that Yb3+ absorbs multiple photons and transfers the energy to Tb3+, causing its 4f electrons to jump to the excited state, and then the upconverting emissions are obtained when electrons return to the ground state. Since the Tb-UCMOF nanosheets have high dispersibility and an obvious upconverting luminescent signal, we explored their luminescence sensing properties. The luminescence intensity is found to gradually decrease with the addition of Cu2+, the linear range of Cu2+ sensing is 0-1.4 μM, and the detection limit is 0.16 μM. This rapid, highly selective, and sensitive Cu2+ sensing indicates that 2-D upconverting MOF nanosheets have great application prospects in luminescence sensing and also promote the research of 2-D upconverting MOFs with specific recognition for the application of biological and environmental luminescent sensors.