SilylboronateMediated Defluorosilylation regarding Aryl Fluorides with or without NiCatalyst

People aged > 65 years received information about ODT, mainly positive, from the television (82%), followed by films (35%), the radio (30%), the press (26%), family (26%), and friends (17%). Receiving information through one of the following sources was associated with a more favorable attitude toward organ donation the family (76% vs 45%; P  less then .001), friends (77% vs 48%; P = .01), and the press (62% vs 49%; P = .034). CONCLUSIONS Older people mainly receive information about ODT from the mass media. However, social and family circles have the greatest influence on their attitudes toward organ donation. INTRODUCTION Spain is a great receptor of immigration from sub-Saharan people like the Senegalese. This population is not very familiar with the process of organ donation and transplantation, and even less toward new therapies related to transplantation, such as xenotransplantation (XenoTx). OBJECTIVE Analyze the attitude toward XenoTx among the Senegalese population living in Spain. MATERIAL AND METHODS Population under study. Population born in Senegal and resident in Spain. Iadademstat INCLUSION CRITERIA Sample of population over 15 years stratified by age and sex, according to census data and immigrant assistance associations. INSTRUMENT Validated questionnaire of attitude toward donation and organ transplantation "PCID-XenoTx-Ríos." Field work. Random selection of respondents based on stratification. The support of immigration support associations was required to obtain sample locations. The completion was anonymous and self-administered. RESULTS A sample of 468 Senegalese was obtained. Twenty percent (n = 92) would accept a solid organ xenotransplant if the results were similar to human organs, 40% (n = 188) have doubts, and 40% (n = 188) would not accept it. If the results were worse than with human organs, only 8% would accept it (n = 38). Respondents with a favorable attitude toward XenoTx presented a more favorable attitude toward cadaveric donation (70.5% vs 31.3%; P  less then .001). The attitude toward acceptance of XenoTx is related to socio-personal factors (P  less then .05), knowledge about the process of organ donation and transplantation (P  less then .05), social interaction factors (P  less then .001), and religious factors (P  less then .05). CONCLUSIONS Senegalese residing in Spain do not have a favorable attitude toward XenoTx. A direct relationship between the attitude toward XenoTx and organ donation is observed. New therapeutic agents such as checkpoint inhibitors are promising strategies in the treatment of metastatic melanoma. Transplant recipients are generally at higher risk of malign diseases. Limited data are available for the use and safety of these agents in this population. We describe a patient who had a stable transplant function over years after a combined heart and kidney transplantation. Immunosuppressive medications included tacrolimus and azathioprine and were later switched to sirolimus and azathioprine. Metastatic melanoma was diagnosed; after detailed explanation of the potential risk, the patient was initially treated with the anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody ipilimumab but experienced an acute kidney graft rejection and rapid progression. Rejection therapy with high-dose corticosteroids was successful, and kidney function was stabilized. Because of the urgent request of the patient for additional therapy, he received a PD-1 inhibitor. Acute kidney graft rejection resulted, with indication for acute dialysis. He developed severe candida pneumonia and died despite extensive antimicrobial therapy. Checkpoint inhibitors have become the standard in a broad entity of tumors. Organ transplant patients are at higher risk of developing malignant diseases. Limited data are available for the use of checkpoint inhibitors in this subgroup, and the use of checkpoint inhibitors is associated with a high risk of graft rejection. Liver grafts from donors after cardiac death (DCD) involve a risk of failure owing to warm ischemia, among other factors. To minimize this important issue, new systems like normothermic regional perfusion have arisen. We report an observational and unicentric study focused on the results of liver transplantation after DCD, performing normothermic regional perfusion using extracorporeal membrane oxygenation. In the period between 2011 and 2018, 33 recipients underwent the procedure, 9 from Maastricht II DCD donor liver transplantation (LT) and 24 from Maastricht III DCD donors. The median recipient survival rose to 67 ± 9 months and 41 ± 7 months, respectively. Only 1 patient suffered from ischemic cholangiopathy needing retransplantation. Therefore, according to our experience, liver grafts from DCD using extracorporeal membrane oxygenation are suitable for LT. BACKGROUND The concept of brain death (BD) is not well understood in the general population; this lack of knowledge is one of the main factors that generates an attitude against organ donation. Older people are a population group that has rarely been studied in relation to organ donation and transplantation (ODT), and it is important to investigate the most important aspects of ODT, such as people's concept of BD. OBJECTIVES To analyze the level of understanding of the concept of BD in people > 65 years of age and the factors that influence their mode of thinking. METHODS A multicenter study was carried out with a representative sample of people > 65 years of age, stratified by sex and geographic location in the southeast of Spain (n = 420). Knowledge of BD as well as the influence of other variables were analyzed through a validated questionnaire about ODT. SPSS version 21.0 (IBM Corp, Armonk, NY, United States) software was used for statistical analysis. Descriptive analysis included Student t test and the χ2 test. RESULTS The questionnaire had a completion rate of 84% (n = 351). In 36% (n = 127) of cases, people ˃ 65 years of age understood the concept of BD. In general, knowledge of this concept has not been associated with other variables including social-family interaction about ODT (P > .05). CONCLUSIONS Older people do not understand the concept of BD. It is, therefore, necessary to carry out informative campaigns on ODT explaining this concept. This would improve organ donation awareness in this particular group of people.