Solubilization of TransResveratrol in Some MonoSolvents and other Propylene Glycerin Water Recipes

In the original publication of the article the affiliation of Kamen Ivanov was inaccurate. The correct affiliation of Kamen Ivanov is given below.19F solid-state NMR is an excellent approach for measuring long-range distances for structure determination and for studying molecular motion. For multi-fluorinated proteins, assignment of 19F chemical shifts has been traditionally carried out using mutagenesis. Here we show 2D 19F-13C correlation experiments that allow efficient assignment of the 19F chemical shifts. see more We have compared several rotational-echo double-resonance-based pulse sequences and 19F-13C cross polarization (CP) for 2D 19F-13C correlation. We found that direct transferred-echo double-resonance (TEDOR) transfer from 19F to 13C and vice versa outperforms out-and-back coherence transfer schemes. 19F detection gives twofold higher sensitivity over 13C detection for the 2D correlation experiment. At MAS frequencies of 25-35 kHz, double-quantum 19F-13C CP has higher coherence transfer efficiencies than zero-quantum CP. The most efficient TEDOR transfer experiment has higher sensitivity than the most efficient double-quantum CP experiment. We demonstrate these 2D 19F-13C correlation experiments on the model compounds t-Boc-4F-phenylalanine and GB1. Application of the 2D 19F-13C TEDOR correlation experiment to the tetrameric influenza BM2 transmembrane peptide shows intermolecular 13C-19F cross peaks that indicate that the BM2 tetramers cluster in the lipid bilayer in an antiparallel fashion. This clustering may be relevant for the virus budding function of this protein.Hematopoietic stem-cell transplantation is widely performed for the treatment of hematologic diseases and is increasingly being used for the experimental treatment of various autoimmune diseases. Despite the rapid evolution of this therapy, the mortality rate of patients undergoing this procedure is still high, mainly due to the development of graft versus host disease (GvHD). Even with the administration of immunosuppressive therapy, some patients manifest the chronic form of the disease. For these cases, infusion of mesenchymal stem cells (MSCs) was proposed as a therapeutic strategy, considering the immunosuppressive potential of these cells. This review describes the main results obtained in cell therapy with MSCs for the treatment of GvHD. Despite the encouraging results found, some points differed among the studies. Although the factors that influence the different results are uncertain, some investigators have suggested that variations in immunosuppressive molecules are responsible for these divergences. We highlight the key role of the HLA-G gene in modulating the immune response, and the importance of the polymorphisms and alleles of this gene associated with the outcome of the transplants. We suggest that the HLA-G gene and its polymorphisms be analyzed as a factor in selecting the MSCs to be used in treating GvHD, given its strong immunosuppressive role.Hypoxia refers to the decrease in oxygen tension in the tissues, and the central effector of the hypoxic response is the transcription factor Hypoxia-Inducible Factor α (HIF1-α). Transient hypoxia in acute events, such as exercising or regeneration after damage, play an important role in skeletal muscle physiology and homeostasis. However, sustained activation of hypoxic signaling is a feature of skeletal muscle injury and disease, which can be a consequence of chronic damage but can also increase the severity of the pathology and worsen its outcome. Here, we review evidence that supports the idea that hypoxia and HIF-1α can contribute to the establishment of fibrosis in skeletal muscle through its crosstalk with other profibrotic factors, such as Transforming growth factor β (TGF-β), the induction of profibrotic cytokines expression, as is the case of Connective Tissue Growth Factor (CTGF/CCN2), or being the target of the Renin-angiotensin system (RAS).OBJECTIVE The prognostic nutrition index is an immunonutritional indicator and postoperative predictor of oncological surgery. However, its prognostic value in cardiovascular disease is unknown. This study assessed the value of the prognostic nutrition index in cardiovascular surgery. METHODS This retrospective study included 453 patients who underwent cardiovascular surgery. The patients were divided according to cutoff values of the prognostic nutrition index less then  48, low prognostic nutrition index group and ≥ 48, high prognostic nutrition index group. Clinicopathologic features, including the preoperative state, surgical procedure, and postoperative morbidity and mortality, were compared between the groups. The Mann-Whitney U or Chi-square test, univariate and multivariate analyses, and log-rank test were used in the statistical analyses. RESULTS Old age, a low body mass index, and elevated creatinine levels correlated significantly with a low prognostic nutrition index. Logistic regression analysis demonstrated that a high prognostic nutrition index status was statistically related to a shorter length of intensive care unit stay, shorter intubation time, and lower incidences of mediastinitis and pneumonia. Multivariate analysis revealed that male sex (hazard ratio 3.93; 95% confidence interval 1.29-11.91, p = 0.016), age (hazard ratio 3.35; 95% confidence interval 1.11-10.15 p = 0.032), and the prognostic nutrition index (hazard ratio 0.40; 95% confidence interval 0.18-0.90, p = 0.026) were independently associated with postoperative survival. CONCLUSIONS A low prognostic nutrition index was significantly associated with postoperative complications and survival. The prognostic nutrition index may be useful and reliable as a preoperative assessment of nutritional status, and it should be considered in the indication and strategy of cardiovascular surgery.Uterus transplantation (UTx) is the first treatment for absolute uterine factor infertility. The first birth after human UTx in Sweden occurred in 2014 and very favourable results of the Swedish trial performed with laparotomy raised great hope. Several teams are leading their own trial among the world, but UTx is still in its experimental phase. Surgical intervention needs to be optimized. The long surgical duration (> 10 h), vascular dissection and risks of ureteral damages for live donors are major drawbacks. Minimal invasive surgery by means of robotic-assisted laparoscopy for live donors could become an improved option. Our collaborative Swedish-French team has initiated efforts to introduce minimal invasive surgery in one trial in Sweden and one in France. UTx is somewhat similar to a radical colpohysterectomy for arterial dissection. We describe a robotic-assisted radical colpohysterectomy and its transposition to uterus retrieval in a living donor. We report our experience on nine cases that were completed prior to our French UTx robot-assisted trial.