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The aim of this research was to analyze the impact of the human body position changes caused by propelling a wheelchair with the pushrim propulsion on the value of motion resistance force. The discussed research works are in progress; therefore, the presented results should be treated as preliminary. The research was carried out in the group of six volunteers propelling a wheelchair of which frame was inclined, in respect to the horizontal plane, under the angle of 0 deg, 7 deg, and 14 deg. The area of the position variability of the human body center of gravity (COG) and the coefficients of wheelchair rolling resistance have been determined. Based on the measurements conducted, rolling resistance force FT and motion resistance force FR have been defined for three values of frame inclination angle. The determined force of rolling resistance Ft depended on the location of the COG of the human body and the value of the coefficients of rolling resistance of the front and rear wheels of a wheelchair. This force wclination angle. The conducted research demonstrated the impact of the COG position on the changes of motion resistance force, thus expanding the state of knowledge, introducing a new parameter which, like a surface type and wheel type, affects motion resistances.This paper studies how biomechanical multibody models of scoliosis can neglect the changes of spinal length and yet be accurate in reconstructing spinal columns. As these models with fixed length comprise rigid links interconnected by rotary joints, they resemble polygonal chains that approximate spine curves with a finite number of line segments. In mathematics, using more segments with shorter lengths can result in more accurate curve approximations. This raises the question of whether more accurate spine curve approximations by increasing the number of links/joints can yield more accurate spinal column reconstructions. For this, the accuracy of spine curve approximation was improved consistently by increasing the number of links/joints, and its effects on the accuracy of spinal column reconstruction were assessed. Positive correlation was found between the accuracy of spine reconstruction and curve approximation. It was shown that while increasing the accuracy of curve approximations, the representation of scoliosis concavity and its side-to-side deviations were improved. Moreover, reconstruction errors of the spine regions separated by the inflection vertebrae had minimal impacts on each other. Overall, multibody scoliosis models with fixed spinal lengths can benefit from the extra rotational joints that contribute toward the accuracy of spine curve approximation. The outcome of this study leads to concurrent accuracy improvement and simplification of multibody models; joint-link configurations can be independently defined for the regions separated by the inflection vertebrae, enabling local optimization of the models for higher accuracy without unnecessary added complexity to the whole model.Step-by-step (SBS) stair navigation is used by those with movement limitations or lower-limb prosthetics and by humanoid robots. Knowledge of biomechanical parameters for SBS gait, however, is limited. Inverted pendulum (IP) models used to assess dynamic stability have not been applied to SBS gait. This study examined the ability of the linear inverted pendulum (LIP) model and a closed-form, variable-height inverted pendulum (VHIP) model to predict capture-point (CP) stability in healthy adults executing a single stair climb. A second goal was to provide baseline kinematic and kinetic data for SBS gait. Twenty young adults executed a single step onto stairs of two heights, while attached marker positions and ground reaction forces were recorded. opensim software determined body kinematics and joint kinetics. Trials were analyzed with LIP and VHIP models, and the predicted CP compared to the actual center-of-pressure (CoP) on the stair. Lower-limb joint moments were larger than those reported for step-over-step (SOS) stair gait. Leading knee rather than trailing ankle was dominant. Peptide 17 Center-of-mass (CoM) velocity peaked at push-off. The VHIP model accounted for only slightly more than half of the forward progression of the vertical projection of the CoM and was not better than LIP predictions. This suggests that IP models are limited in modeling SBS gait, likely due to large hip and knee moments. The results from this study may also provide target values and strategies to aid design of lower-limb prostheses and powered exoskeletons.Molecular dynamics modeling is used to simulate, model, and analyze mechanical deformation behavior and predictive properties of three different synthetic collagen proteins obtained from RSC-PDB, 1BKV, 3A08, and 2CUO, with varying concentrations of hydroxyproline (HYP). Hydroxyproline is credited with providing structural support for the collagen protein molecules. Hydroxyproline's influence on these three synthetic collagen proteins' mechanical deformation behavior and predictive properties is investigated in this paper. A detailed study and inference of the protein's mechanical characteristics associated with HYP content are investigated through fraying deformation behavior. A calculated Gibbs free energy value (ΔG) of each polypeptide α chain that corresponds with a complete unfolding of a single polypeptide α-chain from a triple-helical protein is obtained with umbrella sampling. The force needed for complete separation of the polypeptide α-chain from the triple-helical protein is analyzed for proteins to understand the influence of HYP concentration and is discussed in this paper. Along with a difference in ΔG, different unfolding pathways for the molecule and individual chains are observed. The correlation between the fraying deformation mechanical characteristics and the collagen proteins' hydroxyproline content is provided in this study via the three collagen proteins' resulting binding energies.
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder known for its broad clinical spectrum. Recently, the European, British and Latin American rheumatology professional societies (EULAR, BSR and PANLAR) published updated recommendations for SLE management. The objective of this study was to characterize the data supporting the updated recommendations, with the goal of highlighting areas which could benefit from additional high-quality research.
References were compiled from the recently published EULAR, BSR and PANLAR SLE treatment recommendations. Data collected from each study included publication year, treatment regimen, study design, sample size, inclusion and exclusion criteria and relevant SLE diagnostic criteria. Studies with less than 10 patients and those which did not specify the SLE diagnostic criteria used were excluded.
Altogether 250 studies were included in this study. The majority were prospective and retrospective cohorts (72%), with only a small percentage of randomized controlled trials (28%).