Unaggressive Baited Sequential Debris Soar Lure

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Lupus nephritis (LN) is an important cause of morbidity and even mortality in patients with SLE. Some evidences suggest that neutrophil-lymphocyte ratio (NLR) associated with different inflammatory malignancies, ischemic injury and cardiovascular disease. Few scholars have investigated the relationship between NLR and SLE. This study aims to evaluate the role of NLR in SLE without nephritis and LN patients.
A total of 228 subjects were participated in this study. 79 diagnosed with SLE in patients group and 149 healthy age-and sex-matched in control group. In patient team, 20 of them were diagnosed with LN.
The SLE without nephritis group showed significantly higher NLR than control group (control=2.00±0.76, SLE=4.26±3.38, P<0.001), and the NLR values of the patients with LN were higher than those of the patients without LN (SLE=4.26±3.38, LN=7.21±6.01, P<0.001). Receiver-operating characteristics analysis (ROC) of NLR to predict SLE showed that the area under the curve (AUC) was 0.757. The cutoff value using the ROC curve was 3.13 (sensitivity, 0.574; specificity, 0.926; 95% confidence interval (CI), 0.668-0.845; P<0.001). While ROC analysis of NLR to predict LN showed that the AUC was 0.828). Logistic regression analysis showed that SLE without nephritis and LN were independently related to NLR.
NLR is independently associated with SLE, and it may be a promising marker that reflects renal involvement in patients with SLE.
NLR is independently associated with SLE, and it may be a promising marker that reflects renal involvement in patients with SLE.
Herpes zoster (HZ) duplex is a rare disease presentation. The mechanisms of varicella zoster virus (VZV) reactivation in multiple dermal regions are unknown. To present a HZ duplex case occurring in an immunocompetent woman and to analyze the possible underlying causes of HZ duplex.
We present a HZ duplex case in an immunocompetent woman and analyzed the possible contributing factors in 36 HZ duplex cases. Continuously distributed variables were categorized by numbers and percentages.
In our study, 24 cases (66.7%) were from Asia, 16 cases (44.4%) were in individuals ≥ 50 years of age, and 17 cases (47.2%) occurred in immunocompromised patients. Of the 36 cases, 23 involved women (63.9%) and 13 involved men. Eighteen patients suffering from HZ duplex, 13 of which were women (72.2%), did not suffer from any chronic systemic disease or have a long history of taking drugs.
HZ duplex is a rare event that can occur in both immunocompetent and immunosuppressed individuals. HZ duplex might be associated with the Asia region, advanced age, immunosuppression, and being female.
HZ duplex is a rare event that can occur in both immunocompetent and immunosuppressed individuals. HZ duplex might be associated with the Asia region, advanced age, immunosuppression, and being female.
This study is to investigate risk factors of intracranial hemorrhage and their effects on prognosis in patients with brain intracranial arteriovenous malformation (AVM) after interventional therapy.
A total of 80 cases of brain AVM patients were admitted to our hospital and received interventional embolism treatment from December 2011 to July 2014. The patients all were confirmed by digital subtraction angiography. Risk factors of intracranial hemorrhage after interventional therapy were analyzed by multivariate analysis. The factors included age, sex, AVM diameter, vein drainage types, embolism area, etc. Meanwhile, the patients were followed up for 60 months after interventional embolism therapy, so as to assess the impact of related risk factors on prognosis.
By logistic regression analysis, it was found that age, AVM diameter, AVM combined with aneurysm, embolism area and venous drainage types were related risk factors those could lead to intracranial hemorrhage. Meanwhile, it was identified by receiver operating characteristic curve that embolism area, AVM diameter and AVM combined with aneurysm were risk factors had considerable influence on prognosis while the diagnosis significance of age and venous drainage types was poor (P > 0.05). The survival curves of embolism area and AVM diameter on prognosis had been identified by Kaplan-Meier analysis and it showed that embolism area < 50% and AVM diameter ≥ 3 cm had a better prognosis than embolism area ≥ 50% and AVM diameter < 3 cm (P < 0.05).
A series of risk factors were related to intracranial hemorrhage and some of them had considerable influence on prognosis, which, could help to reduce the risk of intracranial hemorrhage and improve long-term survival rate.
A series of risk factors were related to intracranial hemorrhage and some of them had considerable influence on prognosis, which, could help to reduce the risk of intracranial hemorrhage and improve long-term survival rate.
Portal hypertension is one of the death reasons for the liver cirrhosis patients. The oxidative stress is related to the occurrence and development of portal hypertension in cirrhosis. Malondialdehyde (MDA), one of the lipid peroxides, increases substantially in cirrhotic patients.
To evaluate the relevance between the MDA level and portal hypertension in cirrhotic patients.
60 liver cirrhotic patients and 30 healthy controls were enrolled. The plasma MDA level and general blood tests including ALT, AST, ALB, total bilirubin, and platelet were measured. Cyclopamine Hedgehog antagonist All people enrolled accepted endoscopic examination and B-Ultrasound check to evaluate the severity of portal hypertension.
The MDA plasma level of cirrhotic patients was significantly higher than the controls (P<0.001) and increased significantly accompanied by the severity of liver fibrosis and portal hypertension (P<0.01). Further, the plasma MDA level of cirrhotic patients was significantly correlated with Child-Pugh classification of cirrhosis (r=0.820, P<0.001), the degree of esophageal varices (r=0.857, P<0.001) and the width of portal vein (r=0.652, P<0.001). The ROC curve analyses showed that the plasma MDA level is a strong predictor of liver cirrhosis and portal hypertension.
Plasma MDA level may correlate with the severity of portal hypertension in cirrhotic patients.
Plasma MDA level may correlate with the severity of portal hypertension in cirrhotic patients.
Radiodermatitis is a common side effect of radiotherapy. However, an effective method for the prevention of radiodermatitis has not yet been identified. The purpose of this study was to evaluate the effectiveness of topical olive oil in the prevention of acute radiodermatitis in patients with nasopharyngeal carcinoma (NPC) who were undergoing concurrent chemoradiotherapy.
A prospective study was conducted in patients with NPC. The patients were randomized into the intervention (n = 47) and control (n = 47) groups. Patients in the control group were treated with a general skin care regimen (placebo), whereas patients in the intervention group were treated with olive oil thrice daily for 7 weeks during chemoradiotherapy and for two weeks thereafter. On a weekly basis for a total duration of 9 weeks, a blinded observer assessed the severity of dermatitis, which was graded from 0 to 4 according to the Radiation Therapy Oncology Group (RTOG) criteria and the Visual Analog Scale (VAS) score.
Mild reactions due to radiation (grades I and II) occurred in 93.6% of the intervention group and in 72.3% of the control group. Patients in the intervention group encountered significantly less severe dermatitis during chemoradiotherapy compared with patients in the control group (P < 0.01). A multivariate analysis revealed that the use of olive oil (P < 0.01) was significantly associated with a decrease in skin injuries.
The prophylactic use of olive oil was associated with a significant decrease in the intensity of acute dermatitis in NPC patients. The results of this trial indicate that olive oil holds promise as a safe and effective prophylactic treatment for radiodermatitis.
The prophylactic use of olive oil was associated with a significant decrease in the intensity of acute dermatitis in NPC patients. The results of this trial indicate that olive oil holds promise as a safe and effective prophylactic treatment for radiodermatitis.
selenoprotein S (SelS) gene polymorphism is closely related to a variety of malignant tumours. Here, we evaluate the association between SelS polymorphism and genetic susceptibility to gastric cancer.
A case-control study was conducted to investigate the role of two SelS single nucleotide polymorphisms (SNPs) on the susceptibility to gastric cancer. The genotypes and genotype frequencies of the SelS were determined in 260 gastric cancer patients and 278 age-matched healthy controls. Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype rs28665122 (G-105A) and rs34713741 (G-254A) within the SelS gene. The differences in the genotypic distribution between gastric cancer patients and healthy controls were analyzed with the Chi-square test for trends. Logistic-regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusting for age and sex.
For rs34713741 in SelS, the allele frequencies analysis indicated that the allele frequency of the T was higher in patients than in controls (P=0.001). There were significant differences of genotype frequencies and allele of rs34713741 polymorphism between gastric cancer group and control group (P<0.05). The relative risk of suffering from gastric cancer in T allele was 1.62 times of CC genotype in Hunan Han population (OR=1.62, 95% CI 1.15~2.29). But there were no differences of genotype frequencies and allele of SelS rs28665122 polymorphism between gastric cancer group and control group.
Allele T of SelS rs34713741 polymorphism is significantly associated with an increased risk of gastric cancer in Chinese population.
Allele T of SelS rs34713741 polymorphism is significantly associated with an increased risk of gastric cancer in Chinese population.Polygonum multiflorum, a traditional Chinese medicinal herb, is widely used in liver and liver nourishing. Recent years, drug regulatory departments reported that Polygonum multiflorum caused serious adverse reaction in clinic, especially liver injury. In this study, we detected the changes in rat serum and liver tissue metabolites through gas chromatography-mass spectrometry (GC-MS). Mass spectrometry, partial least squares-discriminate analysis (PLS-DA) and other diversified techniques were used to analyze the differences among their metabolites. Compared to the control group, the serum concentrations of L-threonine and serine in water extraction groups increased. The serum concentrations of 9,12-octadecadienoic acid, hexadecanoic acid, oleic acid, D-glucose and octadecanoic acid in alcohol extraction groups increased, while lactic acid decreased to a great extent. For liver tissue, compared to the control group, the concentrations of myo-inositol, oleic acid and cholesterol in water extraction groups increased, while those of hexadecanoic acid, octadecanoic acid, ribitol and butanedioic acid decreased to a great extent. The concentrations of myo-inositol, phosphoric acid, uridine, oleic acid, cholesterol and butanoic acid in alcohol extraction groups increased to a great extent, while those of hexadecanoic acid, octadecanoic acid, ribitol and butanedioic acid decreased. The results indicate that Polygonum multiflorum induces the metabolic disorders of energy metabolism, amino acid and lipid metabolism. What's more, liver injury of alcohol extraction group was more serious than group of water extraction.