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0% vs 3.3%; RR 1.24, 95% CI 1.11-1.38, p = 0.0002). There was a modest but still significant association in the lowerdose (n-3 FA ≤ 1g daily) sub-group (RR 1.12, 95% CI 1.04-1.21, p = 0.004) and stronger association in the higherdose (n-3 FA > 1g daily) sub-group (RR 1.51, 95% CI 1.26-1.80, p < 0.001; p-interaction between low versus high subgroups = 0.003). There was no increase in stroke risk (RR 1.04, 95% CI 0.90-1.20). Meta-regression demonstrated a significant association between dose of n-3 FA with risk for AF events (log RR 0.103, 95% CI 0.048-0.159, p < 0.001).
While overall AF event rates were low, n-3 FA treatment is associated with increased risk for AF.
While overall AF event rates were low, n-3 FA treatment is associated with increased risk for AF.Evidence-based medicine has been the subject of much controversy within and outside the field of medicine, with its detractors characterizing it as reductionist and authoritarian, and its proponents rejecting such characterization as a caricature of the actual practice. At the heart of this controversy is a complex linguistic and social process that cannot be illuminated by appealing to the semantics of the modifier evidence-based. The complexity lies in the nature of evidence as a basic concept that circulates in both expert and non-expert spheres of communication, supports different interpretations in different contexts, and is inherently open to contestation. We outline a new methodology that combines a social epistemological perspective with advanced methods of corpus linguistics and elements of conceptual history to investigate this and other basic concepts that underpin the practice and ethos of modern medicine. The potential of this methodology to offer new insights into controversies such as those surrounding EBM is demonstrated through a case study of the various meanings supported by evidence and based, as attested in a large electronic corpus of online material written by non-experts as well as a variety of experts in different fields, including medicine.The proposes of this study were to compare THg (total mercury), Pb(Lead), Cd(Cadmium), and Mn (Manganese) contamination in poultry blood between polluted areas (≤ 25 km) and unpolluted areas (> 25 km) adjacent to the largest gold mining in northern Thailand. The THg level in the free-grazing duck in polluted areas was significantly higher than unpolluted area. Both THg and Pb levels in free-grazing duck were also highest in polluted areas. In contrast, the level of (Mn) in chicken blood was the highest in polluted areas. Cadmium in farmed duck from polluted areas was significantly higher than unpolluted areas. The target hazard quotient (THQ) and hazard index (HI) of Hg, Pb, Cd, and Mn in all age groups in both areas did not exceed 1, meaning there is no possibility of the non-carcinogenic toxicity. Whereas, the incremental lifetime cancer risk (ILCR) of both Pb and Cd exceeded 1 × 10-4 in all age groups and these were particularly higher in the polluted area and considered to yield significant health effects of increasing the cancer risk. The ILCR in descending order for Pb and Cd was 13-18 years old = 18-35 years old > 6-13 years old = 35-65 years old > 3-6 years old > 65 up years old, respectively. The results revealed that the human cancer risk related to consuming poultry blood contaminated with both Pb and Cd in all age groups must be of concern, especially 13-18 and 18-35 years, it must be recommended to avoid raising animals in contaminated areas, especially free-grazing duck.
We examined caregiver's knowledge, attitudes, and concerns about their child's psychotropic medication regimen and the potential side effects, describe how they seek information regarding treatment, and ascertain their perspectives toward deprescribing.
We surveyed 48 caregivers of children 6-17years old treated with two or more psychotropic medications or an antipsychotic medication, analyzing outcomes using descriptive statistics.
Almost all (N = 44, 92%) participants reported feeling very knowledgeable about why medications were prescribed, but only one-third (N = 16, 33%) reported feeling very knowledgeable about potential problems with long-term use or polypharmacy. Half of respondents (N = 24, 50%) reported asking their provider about reducing/stopping medications due to concerns about harmful effects, and nearly half (N = 20, 42%) reported stopping medications earlier than recommended.
Interventions to engage caregivers in shared decision-making about complex medication regimens and to support prescribers to safely deprescribe psychotropic medications are needed to address caregivers' concerns regarding psychotropic medication use.
Interventions to engage caregivers in shared decision-making about complex medication regimens and to support prescribers to safely deprescribe psychotropic medications are needed to address caregivers' concerns regarding psychotropic medication use.Data are lacking on the psychiatric and psycho-social profiles of Middle-Eastern people living with HIV (PLHIV). Our study aimed to establish the prevalence and correlates of mental illness in a sample of Lebanese PLHIV, and to delineate their socio-cultural reality. PLHIV, either attending a private ID clinic or a non-governmental organization, were interviewed. A total of 94 patients were included. Sixty-nine (73.4%) were found to have at least one psychiatric disorder. selleck inhibitor Only nine participants were currently receiving psychotropic medications. The most common diagnosis was major depression, occurring in half of the subjects. Homosexual or bisexual orientation predicted the presence of a current depression (p = 0.024), and ART status was negatively associated with current depression (p = 0.028). The rate of psychiatric disorders is clearly higher than that of the general population. PLHIV with a homosexual or bisexual orientation face a double stigma, perhaps making them more vulnerable to depression. Our findings need to be replicated in larger studies with more representative samples.